Training regimen involving cyclic induction of pupil constriction during far accommodation improves visual acuity in myopic children

Kenji Yuda1, Hiroshi Uozato2, Naoto Hara3, Wolfram Tetzlaff4, Satoru Hisahara5, Hiroko Horie6, Satomi Nakajima6, Hidenori Horie6,71Kikuna Yuda Eye Clinic, Yokohama, Japan; 2Department of Ophthalmology and Visual Science, Kitasato&nbsp; University, Kanagawa, Japan; 3Department of Ophthalmolog...

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Autores principales:	Kenji Yuda, Hiroshi Uozato, Naoto Hara, et al
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2010
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/81d8826bb38f466e99220c10da56f7db
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spelling	oai:doaj.org-article:81d8826bb38f466e99220c10da56f7db2021-12-02T07:53:03ZTraining regimen involving cyclic induction of pupil constriction during far accommodation improves visual acuity in myopic children1177-54671177-5483https://doaj.org/article/81d8826bb38f466e99220c10da56f7db2010-04-01T00:00:00Zhttp://www.dovepress.com/training-regimen-involving-cyclic-induction-of-pupil-constriction-duri-a4216https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Kenji Yuda1, Hiroshi Uozato2, Naoto Hara3, Wolfram Tetzlaff4, Satoru Hisahara5, Hiroko Horie6, Satomi Nakajima6, Hidenori Horie6,71Kikuna Yuda Eye Clinic, Yokohama, Japan; 2Department of Ophthalmology and Visual Science, Kitasato&nbsp; University, Kanagawa, Japan; 3Department of Ophthalmology, Yokohama Dental and Medical Clinic, Kanagawa Dental College, Yokohama, Japan; 4ICORD, International Collaboration on Repair Discoveries, Univ. of British Columbia, Vancouver, BC, Canada; 5Panasonic Shikoku Electronics Co., Ltd., Yokohama, Japan; 6TechnoMaster Co., Ltd., Yokohama, Japan; 7Research Center of Brain and Oral Science, Kanagawa Dental College, Yokosuka, JapanPurpose: Myopia in school-age children has become increasingly prevalent in industrialized countries, especially in Asia. A large population of school-age children still suffers from low visual acuity. We have developed a novel, safe and noninvasive training method to activate a pupillary constriction response during far accommodation that results in improved visual acuity.Methods: Myopic children (n = 95) were treated for 3-minute sessions up to twice a week for 12&ndash;106 weeks. We stimulated quick cycles of near/far accommodation by displaying a visual object on a LCD screen and moving the screen in cycles from a near (25 cm) to a far (70 cm) point and back, while keeping the retinal projection size and brightness of the object constant. Results: Mechanistically, we noted pupillary constriction upon far accommodation in trained myopic children, which was not seen in normal subjects or in untrained myopic children. Eighty five percent (52/61) of trained myopic right eyes with two sessions weekly experienced improved visual acuity (VA) by more than 0.1 logMAR units with an average improvement of 0.30 &plusmn; 0.03 standard error of mean (SEM) logMAR units. With maintained training, most eyes&rsquo; improved VA stayed almost constant, for more than 50 weeks in the case of 12 long trained subjects.Conclusions: This simple, short and safe accommodation training greatly improves the quality of vision in a large population suffering from refractive abnormalities.Keywords: accommodation, visual acuity, myopia, pupil constriction, training regimen Kenji YudaHiroshi UozatoNaoto Haraet alDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2010, Iss default, Pp 251-260 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Kenji Yuda Hiroshi Uozato Naoto Hara et al Training regimen involving cyclic induction of pupil constriction during far accommodation improves visual acuity in myopic children
description	Kenji Yuda1, Hiroshi Uozato2, Naoto Hara3, Wolfram Tetzlaff4, Satoru Hisahara5, Hiroko Horie6, Satomi Nakajima6, Hidenori Horie6,71Kikuna Yuda Eye Clinic, Yokohama, Japan; 2Department of Ophthalmology and Visual Science, Kitasato&nbsp; University, Kanagawa, Japan; 3Department of Ophthalmology, Yokohama Dental and Medical Clinic, Kanagawa Dental College, Yokohama, Japan; 4ICORD, International Collaboration on Repair Discoveries, Univ. of British Columbia, Vancouver, BC, Canada; 5Panasonic Shikoku Electronics Co., Ltd., Yokohama, Japan; 6TechnoMaster Co., Ltd., Yokohama, Japan; 7Research Center of Brain and Oral Science, Kanagawa Dental College, Yokosuka, JapanPurpose: Myopia in school-age children has become increasingly prevalent in industrialized countries, especially in Asia. A large population of school-age children still suffers from low visual acuity. We have developed a novel, safe and noninvasive training method to activate a pupillary constriction response during far accommodation that results in improved visual acuity.Methods: Myopic children (n = 95) were treated for 3-minute sessions up to twice a week for 12&ndash;106 weeks. We stimulated quick cycles of near/far accommodation by displaying a visual object on a LCD screen and moving the screen in cycles from a near (25 cm) to a far (70 cm) point and back, while keeping the retinal projection size and brightness of the object constant. Results: Mechanistically, we noted pupillary constriction upon far accommodation in trained myopic children, which was not seen in normal subjects or in untrained myopic children. Eighty five percent (52/61) of trained myopic right eyes with two sessions weekly experienced improved visual acuity (VA) by more than 0.1 logMAR units with an average improvement of 0.30 &plusmn; 0.03 standard error of mean (SEM) logMAR units. With maintained training, most eyes&rsquo; improved VA stayed almost constant, for more than 50 weeks in the case of 12 long trained subjects.Conclusions: This simple, short and safe accommodation training greatly improves the quality of vision in a large population suffering from refractive abnormalities.Keywords: accommodation, visual acuity, myopia, pupil constriction, training regimen
format	article
author	Kenji Yuda Hiroshi Uozato Naoto Hara et al
author_facet	Kenji Yuda Hiroshi Uozato Naoto Hara et al
author_sort	Kenji Yuda
title	Training regimen involving cyclic induction of pupil constriction during far accommodation improves visual acuity in myopic children
title_short	Training regimen involving cyclic induction of pupil constriction during far accommodation improves visual acuity in myopic children
title_full	Training regimen involving cyclic induction of pupil constriction during far accommodation improves visual acuity in myopic children
title_fullStr	Training regimen involving cyclic induction of pupil constriction during far accommodation improves visual acuity in myopic children
title_full_unstemmed	Training regimen involving cyclic induction of pupil constriction during far accommodation improves visual acuity in myopic children
title_sort	training regimen involving cyclic induction of pupil constriction during far accommodation improves visual acuity in myopic children
publisher	Dove Medical Press
publishDate	2010
url	https://doaj.org/article/81d8826bb38f466e99220c10da56f7db
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Training regimen involving cyclic induction of pupil constriction during far accommodation improves visual acuity in myopic children

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