Visual processing mode switching regulated by VIP cells

Abstract The responses of neurons in mouse primary visual cortex (V1) to visual stimuli depend on behavioral states. Specifically, surround suppression is reduced during locomotion. Although locomotion-induced vasoactive intestinal polypeptide positive (VIP) interneuron depolarization can account fo...

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Autores principales:	Jung Hoon Lee, Stefan Mihalas
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/81d9a8fbbc4443bca99024672f3c2a74
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spelling	oai:doaj.org-article:81d9a8fbbc4443bca99024672f3c2a742021-12-02T16:06:16ZVisual processing mode switching regulated by VIP cells10.1038/s41598-017-01830-02045-2322https://doaj.org/article/81d9a8fbbc4443bca99024672f3c2a742017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-01830-0https://doaj.org/toc/2045-2322Abstract The responses of neurons in mouse primary visual cortex (V1) to visual stimuli depend on behavioral states. Specifically, surround suppression is reduced during locomotion. Although locomotion-induced vasoactive intestinal polypeptide positive (VIP) interneuron depolarization can account for the reduction of surround suppression, the functions of VIP cell depolarization are not fully understood. Here we utilize a firing rate model and a computational model to elucidate the potential functions of VIP cell depolarization during locomotion. Our analyses suggest 1) that surround suppression sharpens the visual responses in V1 to a stationary scene, 2) that depolarized VIP cells enhance V1 responses to moving objects by reducing self-induced surround suppression and 3) that during locomotion V1 neuron responses to some features of the moving objects can be selectively enhanced. Thus, VIP cells regulate surround suppression to allow pyramidal neurons to optimally encode visual information independent of behavioral state.Jung Hoon LeeStefan MihalasNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jung Hoon Lee Stefan Mihalas Visual processing mode switching regulated by VIP cells
description	Abstract The responses of neurons in mouse primary visual cortex (V1) to visual stimuli depend on behavioral states. Specifically, surround suppression is reduced during locomotion. Although locomotion-induced vasoactive intestinal polypeptide positive (VIP) interneuron depolarization can account for the reduction of surround suppression, the functions of VIP cell depolarization are not fully understood. Here we utilize a firing rate model and a computational model to elucidate the potential functions of VIP cell depolarization during locomotion. Our analyses suggest 1) that surround suppression sharpens the visual responses in V1 to a stationary scene, 2) that depolarized VIP cells enhance V1 responses to moving objects by reducing self-induced surround suppression and 3) that during locomotion V1 neuron responses to some features of the moving objects can be selectively enhanced. Thus, VIP cells regulate surround suppression to allow pyramidal neurons to optimally encode visual information independent of behavioral state.
format	article
author	Jung Hoon Lee Stefan Mihalas
author_facet	Jung Hoon Lee Stefan Mihalas
author_sort	Jung Hoon Lee
title	Visual processing mode switching regulated by VIP cells
title_short	Visual processing mode switching regulated by VIP cells
title_full	Visual processing mode switching regulated by VIP cells
title_fullStr	Visual processing mode switching regulated by VIP cells
title_full_unstemmed	Visual processing mode switching regulated by VIP cells
title_sort	visual processing mode switching regulated by vip cells
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/81d9a8fbbc4443bca99024672f3c2a74
work_keys_str_mv	AT junghoonlee visualprocessingmodeswitchingregulatedbyvipcells AT stefanmihalas visualprocessingmodeswitchingregulatedbyvipcells
_version_	1718385035328880640

Visual processing mode switching regulated by VIP cells

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