Menopause impacts human brain structure, connectivity, energy metabolism, and amyloid-beta deposition

Abstract All women undergo the menopause transition (MT), a neuro-endocrinological process that impacts aging trajectories of multiple organ systems including brain. The MT occurs over time and is characterized by clinically defined stages with specific neurological symptoms. Yet, little is known of...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Lisa Mosconi, Valentina Berti, Jonathan Dyke, Eva Schelbaum, Steven Jett, Lacey Loughlin, Grace Jang, Aneela Rahman, Hollie Hristov, Silky Pahlajani, Randolph Andrews, Dawn Matthews, Orli Etingin, Christine Ganzer, Mony de Leon, Richard Isaacson, Roberta Diaz Brinton
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/81daf184b2aa468d8c9123d6c47009dc
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:81daf184b2aa468d8c9123d6c47009dc
record_format	dspace
spelling	oai:doaj.org-article:81daf184b2aa468d8c9123d6c47009dc2021-12-02T17:52:41ZMenopause impacts human brain structure, connectivity, energy metabolism, and amyloid-beta deposition10.1038/s41598-021-90084-y2045-2322https://doaj.org/article/81daf184b2aa468d8c9123d6c47009dc2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-90084-yhttps://doaj.org/toc/2045-2322Abstract All women undergo the menopause transition (MT), a neuro-endocrinological process that impacts aging trajectories of multiple organ systems including brain. The MT occurs over time and is characterized by clinically defined stages with specific neurological symptoms. Yet, little is known of how this process impacts the human brain. This multi-modality neuroimaging study indicates substantial differences in brain structure, connectivity, and energy metabolism across MT stages (pre-menopause, peri-menopause, and post-menopause). These effects involved brain regions subserving higher-order cognitive processes and were specific to menopausal endocrine aging rather than chronological aging, as determined by comparison to age-matched males. Brain biomarkers largely stabilized post-menopause, and gray matter volume (GMV) recovered in key brain regions for cognitive aging. Notably, GMV recovery and in vivo brain mitochondria ATP production correlated with preservation of cognitive performance post-menopause, suggesting adaptive compensatory processes. In parallel to the adaptive process, amyloid-β deposition was more pronounced in peri-menopausal and post-menopausal women carrying apolipoprotein E-4 (APOE-4) genotype, the major genetic risk factor for late-onset Alzheimer’s disease, relative to genotype-matched males. These data show that human menopause is a dynamic neurological transition that significantly impacts brain structure, connectivity, and metabolic profile during midlife endocrine aging of the female brain.Lisa MosconiValentina BertiJonathan DykeEva SchelbaumSteven JettLacey LoughlinGrace JangAneela RahmanHollie HristovSilky PahlajaniRandolph AndrewsDawn MatthewsOrli EtinginChristine GanzerMony de LeonRichard IsaacsonRoberta Diaz BrintonNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Lisa Mosconi Valentina Berti Jonathan Dyke Eva Schelbaum Steven Jett Lacey Loughlin Grace Jang Aneela Rahman Hollie Hristov Silky Pahlajani Randolph Andrews Dawn Matthews Orli Etingin Christine Ganzer Mony de Leon Richard Isaacson Roberta Diaz Brinton Menopause impacts human brain structure, connectivity, energy metabolism, and amyloid-beta deposition
description	Abstract All women undergo the menopause transition (MT), a neuro-endocrinological process that impacts aging trajectories of multiple organ systems including brain. The MT occurs over time and is characterized by clinically defined stages with specific neurological symptoms. Yet, little is known of how this process impacts the human brain. This multi-modality neuroimaging study indicates substantial differences in brain structure, connectivity, and energy metabolism across MT stages (pre-menopause, peri-menopause, and post-menopause). These effects involved brain regions subserving higher-order cognitive processes and were specific to menopausal endocrine aging rather than chronological aging, as determined by comparison to age-matched males. Brain biomarkers largely stabilized post-menopause, and gray matter volume (GMV) recovered in key brain regions for cognitive aging. Notably, GMV recovery and in vivo brain mitochondria ATP production correlated with preservation of cognitive performance post-menopause, suggesting adaptive compensatory processes. In parallel to the adaptive process, amyloid-β deposition was more pronounced in peri-menopausal and post-menopausal women carrying apolipoprotein E-4 (APOE-4) genotype, the major genetic risk factor for late-onset Alzheimer’s disease, relative to genotype-matched males. These data show that human menopause is a dynamic neurological transition that significantly impacts brain structure, connectivity, and metabolic profile during midlife endocrine aging of the female brain.
format	article
author	Lisa Mosconi Valentina Berti Jonathan Dyke Eva Schelbaum Steven Jett Lacey Loughlin Grace Jang Aneela Rahman Hollie Hristov Silky Pahlajani Randolph Andrews Dawn Matthews Orli Etingin Christine Ganzer Mony de Leon Richard Isaacson Roberta Diaz Brinton
author_facet	Lisa Mosconi Valentina Berti Jonathan Dyke Eva Schelbaum Steven Jett Lacey Loughlin Grace Jang Aneela Rahman Hollie Hristov Silky Pahlajani Randolph Andrews Dawn Matthews Orli Etingin Christine Ganzer Mony de Leon Richard Isaacson Roberta Diaz Brinton
author_sort	Lisa Mosconi
title	Menopause impacts human brain structure, connectivity, energy metabolism, and amyloid-beta deposition
title_short	Menopause impacts human brain structure, connectivity, energy metabolism, and amyloid-beta deposition
title_full	Menopause impacts human brain structure, connectivity, energy metabolism, and amyloid-beta deposition
title_fullStr	Menopause impacts human brain structure, connectivity, energy metabolism, and amyloid-beta deposition
title_full_unstemmed	Menopause impacts human brain structure, connectivity, energy metabolism, and amyloid-beta deposition
title_sort	menopause impacts human brain structure, connectivity, energy metabolism, and amyloid-beta deposition
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/81daf184b2aa468d8c9123d6c47009dc
work_keys_str_mv	AT lisamosconi menopauseimpactshumanbrainstructureconnectivityenergymetabolismandamyloidbetadeposition AT valentinaberti menopauseimpactshumanbrainstructureconnectivityenergymetabolismandamyloidbetadeposition AT jonathandyke menopauseimpactshumanbrainstructureconnectivityenergymetabolismandamyloidbetadeposition AT evaschelbaum menopauseimpactshumanbrainstructureconnectivityenergymetabolismandamyloidbetadeposition AT stevenjett menopauseimpactshumanbrainstructureconnectivityenergymetabolismandamyloidbetadeposition AT laceyloughlin menopauseimpactshumanbrainstructureconnectivityenergymetabolismandamyloidbetadeposition AT gracejang menopauseimpactshumanbrainstructureconnectivityenergymetabolismandamyloidbetadeposition AT aneelarahman menopauseimpactshumanbrainstructureconnectivityenergymetabolismandamyloidbetadeposition AT holliehristov menopauseimpactshumanbrainstructureconnectivityenergymetabolismandamyloidbetadeposition AT silkypahlajani menopauseimpactshumanbrainstructureconnectivityenergymetabolismandamyloidbetadeposition AT randolphandrews menopauseimpactshumanbrainstructureconnectivityenergymetabolismandamyloidbetadeposition AT dawnmatthews menopauseimpactshumanbrainstructureconnectivityenergymetabolismandamyloidbetadeposition AT orlietingin menopauseimpactshumanbrainstructureconnectivityenergymetabolismandamyloidbetadeposition AT christineganzer menopauseimpactshumanbrainstructureconnectivityenergymetabolismandamyloidbetadeposition AT monydeleon menopauseimpactshumanbrainstructureconnectivityenergymetabolismandamyloidbetadeposition AT richardisaacson menopauseimpactshumanbrainstructureconnectivityenergymetabolismandamyloidbetadeposition AT robertadiazbrinton menopauseimpactshumanbrainstructureconnectivityenergymetabolismandamyloidbetadeposition
_version_	1718379176970420224

Menopause impacts human brain structure, connectivity, energy metabolism, and amyloid-beta deposition

Ejemplares similares