Inhibiting endocytosis in CGRP+ nociceptors attenuates inflammatory pain-like behavior

Inhibiting endocytosis in CGRP+ nociceptors attenuates inflammatory pain-like behavior

The authors show the endocytotic adaptor subunit called AP2A2 is differentially expressed in CGRP+ nociceptors. Locally inhibiting nociceptor endocytosis with a lipidated AP2 inhibitor peptide reduces acute and chronic pain-like behaviour in mice and rats, indicating prolonged analgesia.

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Autores principales: Rasheen Powell, Violet A. Young, Kerri D. Pryce, Garrett D. Sheehan, Kwaku Bonsu, Abdulelah Ahmed, Arin Bhattacharjee
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Q
Acceso en línea:https://doaj.org/article/81e68268407d43f79e922325fc0ccb4b
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spelling oai:doaj.org-article:81e68268407d43f79e922325fc0ccb4b2021-12-02T18:37:16ZInhibiting endocytosis in CGRP+ nociceptors attenuates inflammatory pain-like behavior10.1038/s41467-021-26100-62041-1723https://doaj.org/article/81e68268407d43f79e922325fc0ccb4b2021-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26100-6https://doaj.org/toc/2041-1723The authors show the endocytotic adaptor subunit called AP2A2 is differentially expressed in CGRP+ nociceptors. Locally inhibiting nociceptor endocytosis with a lipidated AP2 inhibitor peptide reduces acute and chronic pain-like behaviour in mice and rats, indicating prolonged analgesia.Rasheen PowellViolet A. YoungKerri D. PryceGarrett D. SheehanKwaku BonsuAbdulelah AhmedArin BhattacharjeeNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Rasheen Powell
Violet A. Young
Kerri D. Pryce
Garrett D. Sheehan
Kwaku Bonsu
Abdulelah Ahmed
Arin Bhattacharjee
Inhibiting endocytosis in CGRP+ nociceptors attenuates inflammatory pain-like behavior
description The authors show the endocytotic adaptor subunit called AP2A2 is differentially expressed in CGRP+ nociceptors. Locally inhibiting nociceptor endocytosis with a lipidated AP2 inhibitor peptide reduces acute and chronic pain-like behaviour in mice and rats, indicating prolonged analgesia.
format article
author Rasheen Powell
Violet A. Young
Kerri D. Pryce
Garrett D. Sheehan
Kwaku Bonsu
Abdulelah Ahmed
Arin Bhattacharjee
author_facet Rasheen Powell
Violet A. Young
Kerri D. Pryce
Garrett D. Sheehan
Kwaku Bonsu
Abdulelah Ahmed
Arin Bhattacharjee
author_sort Rasheen Powell
title Inhibiting endocytosis in CGRP+ nociceptors attenuates inflammatory pain-like behavior
title_short Inhibiting endocytosis in CGRP+ nociceptors attenuates inflammatory pain-like behavior
title_full Inhibiting endocytosis in CGRP+ nociceptors attenuates inflammatory pain-like behavior
title_fullStr Inhibiting endocytosis in CGRP+ nociceptors attenuates inflammatory pain-like behavior
title_full_unstemmed Inhibiting endocytosis in CGRP+ nociceptors attenuates inflammatory pain-like behavior
title_sort inhibiting endocytosis in cgrp+ nociceptors attenuates inflammatory pain-like behavior
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/81e68268407d43f79e922325fc0ccb4b
work_keys_str_mv AT rasheenpowell inhibitingendocytosisincgrpnociceptorsattenuatesinflammatorypainlikebehavior
AT violetayoung inhibitingendocytosisincgrpnociceptorsattenuatesinflammatorypainlikebehavior
AT kerridpryce inhibitingendocytosisincgrpnociceptorsattenuatesinflammatorypainlikebehavior
AT garrettdsheehan inhibitingendocytosisincgrpnociceptorsattenuatesinflammatorypainlikebehavior
AT kwakubonsu inhibitingendocytosisincgrpnociceptorsattenuatesinflammatorypainlikebehavior
AT abdulelahahmed inhibitingendocytosisincgrpnociceptorsattenuatesinflammatorypainlikebehavior
AT arinbhattacharjee inhibitingendocytosisincgrpnociceptorsattenuatesinflammatorypainlikebehavior
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