Associations of vascular and bone status in arthritis patients
Abstract Cardiovascular (CV) disease and osteoporosis (OP) have been associated with rheumatoid arthritis (RA) and ankylosing spondylitis (AS). Bone and vascular biomarkers and parameters along with the effect of 1-year anti-TNF therapy on these markers were assessed in order to determine correlatio...
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2021
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oai:doaj.org-article:81ecefe24d80492490c1152dcc6c80382021-12-02T17:17:39ZAssociations of vascular and bone status in arthritis patients10.1038/s41598-021-99071-92045-2322https://doaj.org/article/81ecefe24d80492490c1152dcc6c80382021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-99071-9https://doaj.org/toc/2045-2322Abstract Cardiovascular (CV) disease and osteoporosis (OP) have been associated with rheumatoid arthritis (RA) and ankylosing spondylitis (AS). Bone and vascular biomarkers and parameters along with the effect of 1-year anti-TNF therapy on these markers were assessed in order to determine correlations between vascular pathophysiology and bone metabolism in RA and AS. Thirty-six patients treated with etanercept or certolizumab pegol and 17 AS patients treated with ETN were included in a 12-month follow-up study. Bone and vascular markers were previously assessed by ELISA. Bone density was measured by DXA and quantitative CT (QCT). Flow-mediated vasodilation (FMD), common carotid intima-media thickness (IMT) and pulse-wave velocity (PWV) were assessed by ultrasound. Multiple correlation analyses indicated associations between bone and vascular markers. Osteoprotegerin, sclerostin and cathepsin K were significantly associated with FMD, IMT and PWV, respectively (p < 0.05). Moreover, total and trabecular BMD determined by QCT inversely correlated with IMT (p < 0.05). On the other hand, among vascular parameters, platelet-derived growth factor BB and IMT correlated with DXA femoral and QCT total BMD, respectively (p < 0.05). In the RM-ANOVA analysis, anti-TNF treatment together with baseline osteocalcin, procollagen 1 N-terminal propeptide (P1NP) or vitamin D3 levels determined one-year changes in IMT (p < 0.05). In the MANOVA analysis, baseline disease activity indices (DAS28, BASDAI), the one-year changes in these indices, as well as CRP exerted effects on multiple correlations between bone and vascular markers (p < 0.05). As the pattern of interactions between bone and vascular biomarkers differed between baseline and after 12 months, anti-TNF therapy influenced these associations. We found a great number of correlations in our RA and AS patients undergoing anti-TNF therapy. Some of the bone markers have been associated with vascular pathophysiology, while some vascular markers correlated with bone status. In arthritis, systemic inflammation and disease activity may drive both vascular and bone disease.Anita PusztaiAttila HamarMonika CzókolyováKatalin GulyásÁgnes HorváthEdit VéghZsófia PethőSzilvia SzamosiEmese BaloghNóra BodnárLevente BodokiÁgnes SzentpéteryHarjit Pal BhattoaGyörgy KerekesBalázs JuhászÉva SzekaneczKatalin HodosiAndrea DomjánSándor SzántóHennie G. RatermanWillem F. LemsZoltán SzekaneczGabriella SzűcsNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021) |
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Medicine R Science Q Anita Pusztai Attila Hamar Monika Czókolyová Katalin Gulyás Ágnes Horváth Edit Végh Zsófia Pethő Szilvia Szamosi Emese Balogh Nóra Bodnár Levente Bodoki Ágnes Szentpétery Harjit Pal Bhattoa György Kerekes Balázs Juhász Éva Szekanecz Katalin Hodosi Andrea Domján Sándor Szántó Hennie G. Raterman Willem F. Lems Zoltán Szekanecz Gabriella Szűcs Associations of vascular and bone status in arthritis patients |
| description |
Abstract Cardiovascular (CV) disease and osteoporosis (OP) have been associated with rheumatoid arthritis (RA) and ankylosing spondylitis (AS). Bone and vascular biomarkers and parameters along with the effect of 1-year anti-TNF therapy on these markers were assessed in order to determine correlations between vascular pathophysiology and bone metabolism in RA and AS. Thirty-six patients treated with etanercept or certolizumab pegol and 17 AS patients treated with ETN were included in a 12-month follow-up study. Bone and vascular markers were previously assessed by ELISA. Bone density was measured by DXA and quantitative CT (QCT). Flow-mediated vasodilation (FMD), common carotid intima-media thickness (IMT) and pulse-wave velocity (PWV) were assessed by ultrasound. Multiple correlation analyses indicated associations between bone and vascular markers. Osteoprotegerin, sclerostin and cathepsin K were significantly associated with FMD, IMT and PWV, respectively (p < 0.05). Moreover, total and trabecular BMD determined by QCT inversely correlated with IMT (p < 0.05). On the other hand, among vascular parameters, platelet-derived growth factor BB and IMT correlated with DXA femoral and QCT total BMD, respectively (p < 0.05). In the RM-ANOVA analysis, anti-TNF treatment together with baseline osteocalcin, procollagen 1 N-terminal propeptide (P1NP) or vitamin D3 levels determined one-year changes in IMT (p < 0.05). In the MANOVA analysis, baseline disease activity indices (DAS28, BASDAI), the one-year changes in these indices, as well as CRP exerted effects on multiple correlations between bone and vascular markers (p < 0.05). As the pattern of interactions between bone and vascular biomarkers differed between baseline and after 12 months, anti-TNF therapy influenced these associations. We found a great number of correlations in our RA and AS patients undergoing anti-TNF therapy. Some of the bone markers have been associated with vascular pathophysiology, while some vascular markers correlated with bone status. In arthritis, systemic inflammation and disease activity may drive both vascular and bone disease. |
| format |
article |
| author |
Anita Pusztai Attila Hamar Monika Czókolyová Katalin Gulyás Ágnes Horváth Edit Végh Zsófia Pethő Szilvia Szamosi Emese Balogh Nóra Bodnár Levente Bodoki Ágnes Szentpétery Harjit Pal Bhattoa György Kerekes Balázs Juhász Éva Szekanecz Katalin Hodosi Andrea Domján Sándor Szántó Hennie G. Raterman Willem F. Lems Zoltán Szekanecz Gabriella Szűcs |
| author_facet |
Anita Pusztai Attila Hamar Monika Czókolyová Katalin Gulyás Ágnes Horváth Edit Végh Zsófia Pethő Szilvia Szamosi Emese Balogh Nóra Bodnár Levente Bodoki Ágnes Szentpétery Harjit Pal Bhattoa György Kerekes Balázs Juhász Éva Szekanecz Katalin Hodosi Andrea Domján Sándor Szántó Hennie G. Raterman Willem F. Lems Zoltán Szekanecz Gabriella Szűcs |
| author_sort |
Anita Pusztai |
| title |
Associations of vascular and bone status in arthritis patients |
| title_short |
Associations of vascular and bone status in arthritis patients |
| title_full |
Associations of vascular and bone status in arthritis patients |
| title_fullStr |
Associations of vascular and bone status in arthritis patients |
| title_full_unstemmed |
Associations of vascular and bone status in arthritis patients |
| title_sort |
associations of vascular and bone status in arthritis patients |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/81ecefe24d80492490c1152dcc6c8038 |
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