Kenny mediates selective autophagic degradation of the IKK complex to control innate immune responses

Selective autophagy describes the selective degradation of cellular components upon stress or nutrient deficiency, but whether it modulates innate immunity is unclear. Here the authors show that Drosophila Kenny may be an evolution-selected autophagy receptor for the down-regulation of innate NF-κB...

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Auteurs principaux: Radu Tusco, Anne-Claire Jacomin, Ashish Jain, Bridget S. Penman, Kenneth Bowitz Larsen, Terje Johansen, Ioannis P. Nezis
Format: article
Langue:EN
Publié: Nature Portfolio 2017
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Accès en ligne:https://doaj.org/article/81ed953ad9ea48a8980dd1e3764b1e04
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Résumé:Selective autophagy describes the selective degradation of cellular components upon stress or nutrient deficiency, but whether it modulates innate immunity is unclear. Here the authors show that Drosophila Kenny may be an evolution-selected autophagy receptor for the down-regulation of innate NF-κB activation