Effects of the ultra-short-acting beta-blocker Esmolol infusion on cardiovascular parameters and quality of postoperative recovery in patients scheduled for elective plastic surgery

Background/Aim: Esmolol is an ultra-short-acting, easily titratable b-adrenergic receptor antagonist used for urgent treatment of hypertension and tachycardia in non-surgical and surgical settings. Aim of this clinical study was to investigate its cardiovascular effects and quality of the emergence...

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Autor principal:	Lončar-Stojiljković Dragana
Formato:	article
Lenguaje:	EN SR
Publicado:	Medical Society of the Republic of Srpska, Banja Luka, University of Banja Luka. Faculty of Medicine 2021
Materias:	esmolol beta-blockers anaesthesia plastic surgery cardiovascular parameters Medicine R
Acceso en línea:	https://doaj.org/article/81ef032ae0c341a2b4a97b4e71a2b907
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spelling	oai:doaj.org-article:81ef032ae0c341a2b4a97b4e71a2b9072021-12-05T21:31:53ZEffects of the ultra-short-acting beta-blocker Esmolol infusion on cardiovascular parameters and quality of postoperative recovery in patients scheduled for elective plastic surgery2490-33292303-795410.5937/scriptamed52-34205https://doaj.org/article/81ef032ae0c341a2b4a97b4e71a2b9072021-01-01T00:00:00Zhttps://scindeks-clanci.ceon.rs/data/pdf/2490-3329/2021/2490-33292103187L.pdfhttps://doaj.org/toc/2490-3329https://doaj.org/toc/2303-7954Background/Aim: Esmolol is an ultra-short-acting, easily titratable b-adrenergic receptor antagonist used for urgent treatment of hypertension and tachycardia in non-surgical and surgical settings. Aim of this clinical study was to investigate its cardiovascular effects and quality of the emergence from anaesthesia in patients scheduled for elective plastic surgery under general balanced anaesthesia. Methods: A total of 30 ASA I/II patients were randomised in two groups of similar demographic characteristics and baseline values of cardiovascular parameters. Esmolol group received esmolol dissolved in glucose 5 % as an intravenous infusion, 0.3 mg/kg/min during the first 5 min and at a rate of 0.1 mg/kg/ min thereafter. Control patients received the solvent only, at the same rate and volume. General balanced anaesthesia was induced with thiopentone sodium and fentanyl and maintained with nitrous oxide and oxygen. Neuromuscular relaxation was assured with pancuronium bromide and was antagonised at the end of operation with atropine and neostigmine. Systolic and diastolic blood pressure and heart rate were registered at all critical phases: (1) immediately prior to the induction (baseline value), (2) induction to anaesthesia, (3) tracheal intubation, (4) first skin incision, (5) surgical manipulation with organs, (6) suture of the surgical wound and (7) tracheal extubation. Drug consumption and quality of postoperative recovery were monitored. Results: In most of the critical phases of anaesthesia and operation, patients from the Esmolol group had significantly lower values of cardiovascular parameters than the patients from the Control group. Esmolol-treated patients needed less fentanyl, droperidol and pancuronium and had faster and smoother emergence from anaesthesia than the control patients. Conclusion: Esmolol improved haemodynamics and post-anaesthesia recovery in patients undergoing elective plastic surgery under general balanced anaesthesia.Lončar-Stojiljković DraganaMedical Society of the Republic of Srpska, Banja Luka, University of Banja Luka. Faculty of Medicinearticleesmololbeta-blockersanaesthesiaplastic surgerycardiovascular parametersMedicineRENSRScripta Medica, Vol 52, Iss 3, Pp 187-192 (2021)
institution	DOAJ
collection	DOAJ
language	EN SR
topic	esmolol beta-blockers anaesthesia plastic surgery cardiovascular parameters Medicine R
spellingShingle	esmolol beta-blockers anaesthesia plastic surgery cardiovascular parameters Medicine R Lončar-Stojiljković Dragana Effects of the ultra-short-acting beta-blocker Esmolol infusion on cardiovascular parameters and quality of postoperative recovery in patients scheduled for elective plastic surgery
description	Background/Aim: Esmolol is an ultra-short-acting, easily titratable b-adrenergic receptor antagonist used for urgent treatment of hypertension and tachycardia in non-surgical and surgical settings. Aim of this clinical study was to investigate its cardiovascular effects and quality of the emergence from anaesthesia in patients scheduled for elective plastic surgery under general balanced anaesthesia. Methods: A total of 30 ASA I/II patients were randomised in two groups of similar demographic characteristics and baseline values of cardiovascular parameters. Esmolol group received esmolol dissolved in glucose 5 % as an intravenous infusion, 0.3 mg/kg/min during the first 5 min and at a rate of 0.1 mg/kg/ min thereafter. Control patients received the solvent only, at the same rate and volume. General balanced anaesthesia was induced with thiopentone sodium and fentanyl and maintained with nitrous oxide and oxygen. Neuromuscular relaxation was assured with pancuronium bromide and was antagonised at the end of operation with atropine and neostigmine. Systolic and diastolic blood pressure and heart rate were registered at all critical phases: (1) immediately prior to the induction (baseline value), (2) induction to anaesthesia, (3) tracheal intubation, (4) first skin incision, (5) surgical manipulation with organs, (6) suture of the surgical wound and (7) tracheal extubation. Drug consumption and quality of postoperative recovery were monitored. Results: In most of the critical phases of anaesthesia and operation, patients from the Esmolol group had significantly lower values of cardiovascular parameters than the patients from the Control group. Esmolol-treated patients needed less fentanyl, droperidol and pancuronium and had faster and smoother emergence from anaesthesia than the control patients. Conclusion: Esmolol improved haemodynamics and post-anaesthesia recovery in patients undergoing elective plastic surgery under general balanced anaesthesia.
format	article
author	Lončar-Stojiljković Dragana
author_facet	Lončar-Stojiljković Dragana
author_sort	Lončar-Stojiljković Dragana
title	Effects of the ultra-short-acting beta-blocker Esmolol infusion on cardiovascular parameters and quality of postoperative recovery in patients scheduled for elective plastic surgery
title_short	Effects of the ultra-short-acting beta-blocker Esmolol infusion on cardiovascular parameters and quality of postoperative recovery in patients scheduled for elective plastic surgery
title_full	Effects of the ultra-short-acting beta-blocker Esmolol infusion on cardiovascular parameters and quality of postoperative recovery in patients scheduled for elective plastic surgery
title_fullStr	Effects of the ultra-short-acting beta-blocker Esmolol infusion on cardiovascular parameters and quality of postoperative recovery in patients scheduled for elective plastic surgery
title_full_unstemmed	Effects of the ultra-short-acting beta-blocker Esmolol infusion on cardiovascular parameters and quality of postoperative recovery in patients scheduled for elective plastic surgery
title_sort	effects of the ultra-short-acting beta-blocker esmolol infusion on cardiovascular parameters and quality of postoperative recovery in patients scheduled for elective plastic surgery
publisher	Medical Society of the Republic of Srpska, Banja Luka, University of Banja Luka. Faculty of Medicine
publishDate	2021
url	https://doaj.org/article/81ef032ae0c341a2b4a97b4e71a2b907
work_keys_str_mv	AT loncarstojiljkovicdragana effectsoftheultrashortactingbetablockeresmololinfusiononcardiovascularparametersandqualityofpostoperativerecoveryinpatientsscheduledforelectiveplasticsurgery
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Effects of the ultra-short-acting beta-blocker Esmolol infusion on cardiovascular parameters and quality of postoperative recovery in patients scheduled for elective plastic surgery

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