Lipid–polymer hybrid nanoparticles as a next-generation drug delivery platform: state of the art, emerging technologies, and perspectives

Lipid–polymer hybrid nanoparticles as a next-generation drug delivery platform: state of the art, emerging technologies, and perspectives

Anubhab Mukherjee,1,2 Ariana K Waters,1,2 Pranav Kalyan,3 Achal Singh Achrol,2 Santosh Kesari,2 Venkata Mahidhar Yenugonda1,2 1Drug Discovery and Nanomedicine Research Program, 2Department of Translational Neurosciences and Neurotherapeutics, John Wayne Cancer Institute, Pacific Neuroscience Instit...

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Autores principales: Mukherjee A, Waters AK, Kalyan P, Achrol AS, Kesari S, Yenugonda VM
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2019
Materias:
Lipid Polymer Hybrid Nanopartcle
Lipid Based Nanoparticle
Polymer Based Nanopartcles
Drug Delivery
Gene Delivery
Medicine (General)
R5-920
Acceso en línea:https://doaj.org/article/81f972ce6c44469f9b9de137c86ec48b
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spelling oai:doaj.org-article:81f972ce6c44469f9b9de137c86ec48b2021-12-02T03:01:18ZLipid–polymer hybrid nanoparticles as a next-generation drug delivery platform: state of the art, emerging technologies, and perspectives1178-2013https://doaj.org/article/81f972ce6c44469f9b9de137c86ec48b2019-03-01T00:00:00Zhttps://www.dovepress.com/lipid-polymer-hybrid-nanoparticles-as-a-next-generation-drug-delivery--peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Anubhab Mukherjee,1,2 Ariana K Waters,1,2 Pranav Kalyan,3 Achal Singh Achrol,2 Santosh Kesari,2 Venkata Mahidhar Yenugonda1,2 1Drug Discovery and Nanomedicine Research Program, 2Department of Translational Neurosciences and Neurotherapeutics, John Wayne Cancer Institute, Pacific Neuroscience Institute, Providence Saint John’s Health Center, Santa Monica, CA, USA; 3Agoura High School, Agoura Hills, CA, USA Abstract: Lipid–polymer hybrid nanoparticles (LPHNPs) are next-generation core–shell nanostructures, conceptually derived from both liposome and polymeric nanoparticles (NPs), where a polymer core remains enveloped by a lipid layer. Although they have garnered significant interest, they remain not yet widely exploited or ubiquitous. Recently, a fundamental transformation has occurred in the preparation of LPHNPs, characterized by a transition from a two-step to a one-step strategy, involving synchronous self-assembly of polymers and lipids. Owing to its two-in-one structure, this approach is of particular interest as a combinatorial drug delivery platform in oncology. In particular, the outer surface can be decorated in multifarious ways for active targeting of anticancer therapy, delivery of DNA or RNA materials, and use as a diagnostic imaging agent. This review will provide an update on recent key advancements in design, synthesis, and bioactivity evaluation as well as discussion of future clinical possibilities of LPHNPs. Keywords: lipid–polymer hybrid nanoparticle, lipid-based nanoparticle, polymer-based nanoparticles, drug delivery, gene deliveryMukherjee AWaters AKKalyan PAchrol ASKesari SYenugonda VMDove Medical PressarticleLipid Polymer Hybrid NanopartcleLipid Based NanoparticlePolymer Based NanopartclesDrug DeliveryGene DeliveryMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 14, Pp 1937-1952 (2019)
institution DOAJ
collection DOAJ
language EN
topic Lipid Polymer Hybrid Nanopartcle
Lipid Based Nanoparticle
Polymer Based Nanopartcles
Drug Delivery
Gene Delivery
Medicine (General)
R5-920
spellingShingle Lipid Polymer Hybrid Nanopartcle
Lipid Based Nanoparticle
Polymer Based Nanopartcles
Drug Delivery
Gene Delivery
Medicine (General)
R5-920
Mukherjee A
Waters AK
Kalyan P
Achrol AS
Kesari S
Yenugonda VM
Lipid–polymer hybrid nanoparticles as a next-generation drug delivery platform: state of the art, emerging technologies, and perspectives
description Anubhab Mukherjee,1,2 Ariana K Waters,1,2 Pranav Kalyan,3 Achal Singh Achrol,2 Santosh Kesari,2 Venkata Mahidhar Yenugonda1,2 1Drug Discovery and Nanomedicine Research Program, 2Department of Translational Neurosciences and Neurotherapeutics, John Wayne Cancer Institute, Pacific Neuroscience Institute, Providence Saint John’s Health Center, Santa Monica, CA, USA; 3Agoura High School, Agoura Hills, CA, USA Abstract: Lipid–polymer hybrid nanoparticles (LPHNPs) are next-generation core–shell nanostructures, conceptually derived from both liposome and polymeric nanoparticles (NPs), where a polymer core remains enveloped by a lipid layer. Although they have garnered significant interest, they remain not yet widely exploited or ubiquitous. Recently, a fundamental transformation has occurred in the preparation of LPHNPs, characterized by a transition from a two-step to a one-step strategy, involving synchronous self-assembly of polymers and lipids. Owing to its two-in-one structure, this approach is of particular interest as a combinatorial drug delivery platform in oncology. In particular, the outer surface can be decorated in multifarious ways for active targeting of anticancer therapy, delivery of DNA or RNA materials, and use as a diagnostic imaging agent. This review will provide an update on recent key advancements in design, synthesis, and bioactivity evaluation as well as discussion of future clinical possibilities of LPHNPs. Keywords: lipid–polymer hybrid nanoparticle, lipid-based nanoparticle, polymer-based nanoparticles, drug delivery, gene delivery
format article
author Mukherjee A
Waters AK
Kalyan P
Achrol AS
Kesari S
Yenugonda VM
author_facet Mukherjee A
Waters AK
Kalyan P
Achrol AS
Kesari S
Yenugonda VM
author_sort Mukherjee A
title Lipid–polymer hybrid nanoparticles as a next-generation drug delivery platform: state of the art, emerging technologies, and perspectives
title_short Lipid–polymer hybrid nanoparticles as a next-generation drug delivery platform: state of the art, emerging technologies, and perspectives
title_full Lipid–polymer hybrid nanoparticles as a next-generation drug delivery platform: state of the art, emerging technologies, and perspectives
title_fullStr Lipid–polymer hybrid nanoparticles as a next-generation drug delivery platform: state of the art, emerging technologies, and perspectives
title_full_unstemmed Lipid–polymer hybrid nanoparticles as a next-generation drug delivery platform: state of the art, emerging technologies, and perspectives
title_sort lipid–polymer hybrid nanoparticles as a next-generation drug delivery platform: state of the art, emerging technologies, and perspectives
publisher Dove Medical Press
publishDate 2019
url https://doaj.org/article/81f972ce6c44469f9b9de137c86ec48b
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AT watersak lipidndashpolymerhybridnanoparticlesasanextgenerationdrugdeliveryplatformstateoftheartemergingtechnologiesandperspectives
AT kalyanp lipidndashpolymerhybridnanoparticlesasanextgenerationdrugdeliveryplatformstateoftheartemergingtechnologiesandperspectives
AT achrolas lipidndashpolymerhybridnanoparticlesasanextgenerationdrugdeliveryplatformstateoftheartemergingtechnologiesandperspectives
AT kesaris lipidndashpolymerhybridnanoparticlesasanextgenerationdrugdeliveryplatformstateoftheartemergingtechnologiesandperspectives
AT yenugondavm lipidndashpolymerhybridnanoparticlesasanextgenerationdrugdeliveryplatformstateoftheartemergingtechnologiesandperspectives
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