Germline genome editing: Moratorium, hard law, or an informed adaptive consensus?

With the development of practical means of human germline genome editing (HGGE) in recent years, there have been calls for stricter regulation and oversight over HGGE interventions with potential for heritable changes in the germline. An international moratorium has been advocated. We examine the pr...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Terry Kaan, Vicki Xafis, G Owen Schaefer, Yujia Zhu, Markus K Labude, Ruth Chadwick
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Genetics QH426-470
Acceso en línea:	https://doaj.org/article/82031baa5f514af182e442fb076bbae6
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:82031baa5f514af182e442fb076bbae6
record_format	dspace
spelling	oai:doaj.org-article:82031baa5f514af182e442fb076bbae62021-12-02T20:03:21ZGermline genome editing: Moratorium, hard law, or an informed adaptive consensus?1553-73901553-740410.1371/journal.pgen.1009742https://doaj.org/article/82031baa5f514af182e442fb076bbae62021-09-01T00:00:00Zhttps://doi.org/10.1371/journal.pgen.1009742https://doaj.org/toc/1553-7390https://doaj.org/toc/1553-7404With the development of practical means of human germline genome editing (HGGE) in recent years, there have been calls for stricter regulation and oversight over HGGE interventions with potential for heritable changes in the germline. An international moratorium has been advocated. We examine the practicality of such a proposal, as well as of a regulation through the "traditional" mechanisms of international and municipal laws. We argue that these mechanisms are unlikely to achieve their intended objectives and that the better approach is to engage the international community of stakeholders, researchers, scientists, clinicians, and other workers directly involved in the field in working toward the development of an "informed adaptive consensus". We offer suggestions as to how this may be achieved and how existing indirect levers of regulation may be harnessed toward this end.Terry KaanVicki XafisG Owen SchaeferYujia ZhuMarkus K LabudeRuth ChadwickPublic Library of Science (PLoS)articleGeneticsQH426-470ENPLoS Genetics, Vol 17, Iss 9, p e1009742 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Genetics QH426-470
spellingShingle	Genetics QH426-470 Terry Kaan Vicki Xafis G Owen Schaefer Yujia Zhu Markus K Labude Ruth Chadwick Germline genome editing: Moratorium, hard law, or an informed adaptive consensus?
description	With the development of practical means of human germline genome editing (HGGE) in recent years, there have been calls for stricter regulation and oversight over HGGE interventions with potential for heritable changes in the germline. An international moratorium has been advocated. We examine the practicality of such a proposal, as well as of a regulation through the "traditional" mechanisms of international and municipal laws. We argue that these mechanisms are unlikely to achieve their intended objectives and that the better approach is to engage the international community of stakeholders, researchers, scientists, clinicians, and other workers directly involved in the field in working toward the development of an "informed adaptive consensus". We offer suggestions as to how this may be achieved and how existing indirect levers of regulation may be harnessed toward this end.
format	article
author	Terry Kaan Vicki Xafis G Owen Schaefer Yujia Zhu Markus K Labude Ruth Chadwick
author_facet	Terry Kaan Vicki Xafis G Owen Schaefer Yujia Zhu Markus K Labude Ruth Chadwick
author_sort	Terry Kaan
title	Germline genome editing: Moratorium, hard law, or an informed adaptive consensus?
title_short	Germline genome editing: Moratorium, hard law, or an informed adaptive consensus?
title_full	Germline genome editing: Moratorium, hard law, or an informed adaptive consensus?
title_fullStr	Germline genome editing: Moratorium, hard law, or an informed adaptive consensus?
title_full_unstemmed	Germline genome editing: Moratorium, hard law, or an informed adaptive consensus?
title_sort	germline genome editing: moratorium, hard law, or an informed adaptive consensus?
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/82031baa5f514af182e442fb076bbae6
work_keys_str_mv	AT terrykaan germlinegenomeeditingmoratoriumhardlaworaninformedadaptiveconsensus AT vickixafis germlinegenomeeditingmoratoriumhardlaworaninformedadaptiveconsensus AT gowenschaefer germlinegenomeeditingmoratoriumhardlaworaninformedadaptiveconsensus AT yujiazhu germlinegenomeeditingmoratoriumhardlaworaninformedadaptiveconsensus AT markusklabude germlinegenomeeditingmoratoriumhardlaworaninformedadaptiveconsensus AT ruthchadwick germlinegenomeeditingmoratoriumhardlaworaninformedadaptiveconsensus
_version_	1718375670237626368

Germline genome editing: Moratorium, hard law, or an informed adaptive consensus?

Ejemplares similares