Elimination of fukutin reveals cellular and molecular pathomechanisms in muscular dystrophy-associated heart failure

Mutations in Ftkn cause Fukuyama muscular dystrophy, and heart failure is the main cause of death in thes patients. Here the authors show that acute elimination of Fktn in adult mice causes early mortality, and this is associated with myocyte dysfunction, with disorganised Golg-microtubule networks,...

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Autores principales:	Yoshihiro Ujihara, Motoi Kanagawa, Satoshi Mohri, Satomi Takatsu, Kazuhiro Kobayashi, Tatsushi Toda, Keiji Naruse, Yuki Katanosaka
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/820773bb827b414a804a856b83957e6d
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spelling	oai:doaj.org-article:820773bb827b414a804a856b83957e6d2021-12-02T14:39:56ZElimination of fukutin reveals cellular and molecular pathomechanisms in muscular dystrophy-associated heart failure10.1038/s41467-019-13623-22041-1723https://doaj.org/article/820773bb827b414a804a856b83957e6d2019-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13623-2https://doaj.org/toc/2041-1723Mutations in Ftkn cause Fukuyama muscular dystrophy, and heart failure is the main cause of death in thes patients. Here the authors show that acute elimination of Fktn in adult mice causes early mortality, and this is associated with myocyte dysfunction, with disorganised Golg-microtubule networks, and that the pathology can be ameliorated with colchicine treatment.Yoshihiro UjiharaMotoi KanagawaSatoshi MohriSatomi TakatsuKazuhiro KobayashiTatsushi TodaKeiji NaruseYuki KatanosakaNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yoshihiro Ujihara Motoi Kanagawa Satoshi Mohri Satomi Takatsu Kazuhiro Kobayashi Tatsushi Toda Keiji Naruse Yuki Katanosaka Elimination of fukutin reveals cellular and molecular pathomechanisms in muscular dystrophy-associated heart failure
description	Mutations in Ftkn cause Fukuyama muscular dystrophy, and heart failure is the main cause of death in thes patients. Here the authors show that acute elimination of Fktn in adult mice causes early mortality, and this is associated with myocyte dysfunction, with disorganised Golg-microtubule networks, and that the pathology can be ameliorated with colchicine treatment.
format	article
author	Yoshihiro Ujihara Motoi Kanagawa Satoshi Mohri Satomi Takatsu Kazuhiro Kobayashi Tatsushi Toda Keiji Naruse Yuki Katanosaka
author_facet	Yoshihiro Ujihara Motoi Kanagawa Satoshi Mohri Satomi Takatsu Kazuhiro Kobayashi Tatsushi Toda Keiji Naruse Yuki Katanosaka
author_sort	Yoshihiro Ujihara
title	Elimination of fukutin reveals cellular and molecular pathomechanisms in muscular dystrophy-associated heart failure
title_short	Elimination of fukutin reveals cellular and molecular pathomechanisms in muscular dystrophy-associated heart failure
title_full	Elimination of fukutin reveals cellular and molecular pathomechanisms in muscular dystrophy-associated heart failure
title_fullStr	Elimination of fukutin reveals cellular and molecular pathomechanisms in muscular dystrophy-associated heart failure
title_full_unstemmed	Elimination of fukutin reveals cellular and molecular pathomechanisms in muscular dystrophy-associated heart failure
title_sort	elimination of fukutin reveals cellular and molecular pathomechanisms in muscular dystrophy-associated heart failure
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/820773bb827b414a804a856b83957e6d
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Elimination of fukutin reveals cellular and molecular pathomechanisms in muscular dystrophy-associated heart failure

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