Elimination of fukutin reveals cellular and molecular pathomechanisms in muscular dystrophy-associated heart failure
Mutations in Ftkn cause Fukuyama muscular dystrophy, and heart failure is the main cause of death in thes patients. Here the authors show that acute elimination of Fktn in adult mice causes early mortality, and this is associated with myocyte dysfunction, with disorganised Golg-microtubule networks,...
Guardado en:
Autores principales: | Yoshihiro Ujihara, Motoi Kanagawa, Satoshi Mohri, Satomi Takatsu, Kazuhiro Kobayashi, Tatsushi Toda, Keiji Naruse, Yuki Katanosaka |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2019
|
Materias: | |
Acceso en línea: | https://doaj.org/article/820773bb827b414a804a856b83957e6d |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
Crystal structures of fukutin-related protein (FKRP), a ribitol-phosphate transferase related to muscular dystrophy
por: Naoyuki Kuwabara, et al.
Publicado: (2020) -
Evaluation of muscular changes by ultrasound Nakagami imaging in Duchenne muscular dystrophy
por: Wen-Chin Weng, et al.
Publicado: (2017) -
PABPN1 gene therapy for oculopharyngeal muscular dystrophy
por: A. Malerba, et al.
Publicado: (2017) -
Computer task performance by subjects with Duchenne muscular dystrophy
por: Malheiros SRP, et al.
Publicado: (2015) -
Current and emerging treatment strategies for Duchenne muscular dystrophy
por: Mah JK
Publicado: (2016)