Effects of Arachidonic Acid Metabolites on Cardiovascular Health and Disease

Arachidonic acid (AA) is an essential fatty acid that is released by phospholipids in cell membranes and metabolized by cyclooxygenase (COX), cytochrome P450 (CYP) enzymes, and lipid oxygenase (LOX) pathways to regulate complex cardiovascular function under physiological and pathological conditions....

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Yan Zhou, Haroon Khan, Jianbo Xiao, Wai San Cheang
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	arachidonic acid prostaglandin cardiovascular disease vascular tone Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/82088b98216d4b34bff2a6307cd0172d
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:82088b98216d4b34bff2a6307cd0172d
record_format	dspace
spelling	oai:doaj.org-article:82088b98216d4b34bff2a6307cd0172d2021-11-11T17:25:49ZEffects of Arachidonic Acid Metabolites on Cardiovascular Health and Disease10.3390/ijms2221120291422-00671661-6596https://doaj.org/article/82088b98216d4b34bff2a6307cd0172d2021-11-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/12029https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Arachidonic acid (AA) is an essential fatty acid that is released by phospholipids in cell membranes and metabolized by cyclooxygenase (COX), cytochrome P450 (CYP) enzymes, and lipid oxygenase (LOX) pathways to regulate complex cardiovascular function under physiological and pathological conditions. Various AA metabolites include prostaglandins, prostacyclin, thromboxanes, hydroxyeicosatetraenoic acids, leukotrienes, lipoxins, and epoxyeicosatrienoic acids. The AA metabolites play important and differential roles in the modulation of vascular tone, and cardiovascular complications including atherosclerosis, hypertension, and myocardial infarction upon actions to different receptors and vascular beds. This article reviews the roles of AA metabolism in cardiovascular health and disease as well as their potential therapeutic implication.Yan ZhouHaroon KhanJianbo XiaoWai San CheangMDPI AGarticlearachidonic acidprostaglandincardiovascular diseasevascular toneBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 12029, p 12029 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	arachidonic acid prostaglandin cardiovascular disease vascular tone Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	arachidonic acid prostaglandin cardiovascular disease vascular tone Biology (General) QH301-705.5 Chemistry QD1-999 Yan Zhou Haroon Khan Jianbo Xiao Wai San Cheang Effects of Arachidonic Acid Metabolites on Cardiovascular Health and Disease
description	Arachidonic acid (AA) is an essential fatty acid that is released by phospholipids in cell membranes and metabolized by cyclooxygenase (COX), cytochrome P450 (CYP) enzymes, and lipid oxygenase (LOX) pathways to regulate complex cardiovascular function under physiological and pathological conditions. Various AA metabolites include prostaglandins, prostacyclin, thromboxanes, hydroxyeicosatetraenoic acids, leukotrienes, lipoxins, and epoxyeicosatrienoic acids. The AA metabolites play important and differential roles in the modulation of vascular tone, and cardiovascular complications including atherosclerosis, hypertension, and myocardial infarction upon actions to different receptors and vascular beds. This article reviews the roles of AA metabolism in cardiovascular health and disease as well as their potential therapeutic implication.
format	article
author	Yan Zhou Haroon Khan Jianbo Xiao Wai San Cheang
author_facet	Yan Zhou Haroon Khan Jianbo Xiao Wai San Cheang
author_sort	Yan Zhou
title	Effects of Arachidonic Acid Metabolites on Cardiovascular Health and Disease
title_short	Effects of Arachidonic Acid Metabolites on Cardiovascular Health and Disease
title_full	Effects of Arachidonic Acid Metabolites on Cardiovascular Health and Disease
title_fullStr	Effects of Arachidonic Acid Metabolites on Cardiovascular Health and Disease
title_full_unstemmed	Effects of Arachidonic Acid Metabolites on Cardiovascular Health and Disease
title_sort	effects of arachidonic acid metabolites on cardiovascular health and disease
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/82088b98216d4b34bff2a6307cd0172d
work_keys_str_mv	AT yanzhou effectsofarachidonicacidmetabolitesoncardiovascularhealthanddisease AT haroonkhan effectsofarachidonicacidmetabolitesoncardiovascularhealthanddisease AT jianboxiao effectsofarachidonicacidmetabolitesoncardiovascularhealthanddisease AT waisancheang effectsofarachidonicacidmetabolitesoncardiovascularhealthanddisease
_version_	1718432072678244352

Effects of Arachidonic Acid Metabolites on Cardiovascular Health and Disease

Ejemplares similares