Diagnosis of Parkinson's disease based on disease-specific autoantibody profiles in human sera.

Parkinson's disease (PD), hallmarked by a variety of motor disorders and neurological decline, is the second most common neurodegenerative disease worldwide. Currently, no diagnostic test exists to identify sufferers, and physicians must rely on a combination of subjective physical and neurolog...

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Autores principales:	Min Han, Eric Nagele, Cassandra DeMarshall, Nimish Acharya, Robert Nagele
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/820aeca8b17444f0b60b0899a70e8ee2
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spelling	oai:doaj.org-article:820aeca8b17444f0b60b0899a70e8ee22021-11-18T07:27:00ZDiagnosis of Parkinson's disease based on disease-specific autoantibody profiles in human sera.1932-620310.1371/journal.pone.0032383https://doaj.org/article/820aeca8b17444f0b60b0899a70e8ee22012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22384236/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Parkinson's disease (PD), hallmarked by a variety of motor disorders and neurological decline, is the second most common neurodegenerative disease worldwide. Currently, no diagnostic test exists to identify sufferers, and physicians must rely on a combination of subjective physical and neurological assessments to make a diagnosis. The discovery of definitive blood-borne biomarkers would be a major step towards early and reliable diagnosis. Despite attention devoted to this search, such biomarkers have remained elusive. In the present study, we used human protein microarrays to reveal serum autoantibodies that are differentially expressed among PD and control subjects. The diagnostic significance of each of these autoantibodies was evaluated, resulting in the selection of 10 autoantibody biomarkers that can effectively differentiate PD sera from control sera with a sensitivity of 93.1% and specificity of 100%. PD sera were also distinguishable from sera obtained from Alzheimer's disease, breast cancer, and multiple sclerosis patients with accuracies of 86.0%, 96.6%, and 100%, respectively. Results demonstrate that serum autoantibodies can be used as highly specific and accurate biomarkers for PD diagnosis throughout the course of the disease.Min HanMin HanEric NageleCassandra DeMarshallNimish AcharyaRobert NagelePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 2, p e32383 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Min Han Min Han Eric Nagele Cassandra DeMarshall Nimish Acharya Robert Nagele Diagnosis of Parkinson's disease based on disease-specific autoantibody profiles in human sera.
description	Parkinson's disease (PD), hallmarked by a variety of motor disorders and neurological decline, is the second most common neurodegenerative disease worldwide. Currently, no diagnostic test exists to identify sufferers, and physicians must rely on a combination of subjective physical and neurological assessments to make a diagnosis. The discovery of definitive blood-borne biomarkers would be a major step towards early and reliable diagnosis. Despite attention devoted to this search, such biomarkers have remained elusive. In the present study, we used human protein microarrays to reveal serum autoantibodies that are differentially expressed among PD and control subjects. The diagnostic significance of each of these autoantibodies was evaluated, resulting in the selection of 10 autoantibody biomarkers that can effectively differentiate PD sera from control sera with a sensitivity of 93.1% and specificity of 100%. PD sera were also distinguishable from sera obtained from Alzheimer's disease, breast cancer, and multiple sclerosis patients with accuracies of 86.0%, 96.6%, and 100%, respectively. Results demonstrate that serum autoantibodies can be used as highly specific and accurate biomarkers for PD diagnosis throughout the course of the disease.
format	article
author	Min Han Min Han Eric Nagele Cassandra DeMarshall Nimish Acharya Robert Nagele
author_facet	Min Han Min Han Eric Nagele Cassandra DeMarshall Nimish Acharya Robert Nagele
author_sort	Min Han
title	Diagnosis of Parkinson's disease based on disease-specific autoantibody profiles in human sera.
title_short	Diagnosis of Parkinson's disease based on disease-specific autoantibody profiles in human sera.
title_full	Diagnosis of Parkinson's disease based on disease-specific autoantibody profiles in human sera.
title_fullStr	Diagnosis of Parkinson's disease based on disease-specific autoantibody profiles in human sera.
title_full_unstemmed	Diagnosis of Parkinson's disease based on disease-specific autoantibody profiles in human sera.
title_sort	diagnosis of parkinson's disease based on disease-specific autoantibody profiles in human sera.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/820aeca8b17444f0b60b0899a70e8ee2
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Diagnosis of Parkinson's disease based on disease-specific autoantibody profiles in human sera.

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