Formation of sustained antitumor effect in mice’s liver and spleen (CBA х C57BL/6)F1 after a single intravenous injection of zymosan-treated neutrophils

Application of zymosan in medicine is limited because of its side effects, since the native granules of zymosan directly activate serum complement components and phagocytic cells. In this regard, it was decided at the outset (ex vivo) to incorporate the granules of zymosan in the neutrophils, and on...

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Autores principales:	A. G. Lyubimov, G. Y. Lyubimov, V. A. Kozlov
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2016
Materias:	melanoma neutrophils zymosan glucan liver tumors spleen Science Q
Acceso en línea:	https://doaj.org/article/820d9422bfb04e079b7c77e941d3681f
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spelling	oai:doaj.org-article:820d9422bfb04e079b7c77e941d3681f2021-11-23T06:14:36ZFormation of sustained antitumor effect in mice’s liver and spleen (CBA х C57BL/6)F1 after a single intravenous injection of zymosan-treated neutrophils2541-94202587-959610.12737/23403https://doaj.org/article/820d9422bfb04e079b7c77e941d3681f2016-09-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/289https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596Application of zymosan in medicine is limited because of its side effects, since the native granules of zymosan directly activate serum complement components and phagocytic cells. In this regard, it was decided at the outset (ex vivo) to incorporate the granules of zymosan in the neutrophils, and only then inject these "loaded" zymosan neutrophils into the bloodstream. Our experiments showed a total inhibition of the weight accretion of both tumor affected liver (from 5220 ± 963 to 1327 ± 219 mg) and spleen (from 328 ± 29 to 187 ± 64 mg) of mice. Thus these data showed that even on the 17th day after a single intravenous injection zymosan-treated neutrophils persist expressed manifestations of anti-tumor activity in the liver and spleen, that may be basis for using this method for antimetastatic preventive measures in liver and other localizations.A. G. LyubimovG. Y. LyubimovV. A. KozlovScientific Сentre for Family Health and Human Reproduction Problemsarticlemelanomaneutrophilszymosanglucanliver tumorsspleenScienceQRUActa Biomedica Scientifica, Vol 1, Iss 5, Pp 110-113 (2016)
institution	DOAJ
collection	DOAJ
language	RU
topic	melanoma neutrophils zymosan glucan liver tumors spleen Science Q
spellingShingle	melanoma neutrophils zymosan glucan liver tumors spleen Science Q A. G. Lyubimov G. Y. Lyubimov V. A. Kozlov Formation of sustained antitumor effect in mice’s liver and spleen (CBA х C57BL/6)F1 after a single intravenous injection of zymosan-treated neutrophils
description	Application of zymosan in medicine is limited because of its side effects, since the native granules of zymosan directly activate serum complement components and phagocytic cells. In this regard, it was decided at the outset (ex vivo) to incorporate the granules of zymosan in the neutrophils, and only then inject these "loaded" zymosan neutrophils into the bloodstream. Our experiments showed a total inhibition of the weight accretion of both tumor affected liver (from 5220 ± 963 to 1327 ± 219 mg) and spleen (from 328 ± 29 to 187 ± 64 mg) of mice. Thus these data showed that even on the 17th day after a single intravenous injection zymosan-treated neutrophils persist expressed manifestations of anti-tumor activity in the liver and spleen, that may be basis for using this method for antimetastatic preventive measures in liver and other localizations.
format	article
author	A. G. Lyubimov G. Y. Lyubimov V. A. Kozlov
author_facet	A. G. Lyubimov G. Y. Lyubimov V. A. Kozlov
author_sort	A. G. Lyubimov
title	Formation of sustained antitumor effect in mice’s liver and spleen (CBA х C57BL/6)F1 after a single intravenous injection of zymosan-treated neutrophils
title_short	Formation of sustained antitumor effect in mice’s liver and spleen (CBA х C57BL/6)F1 after a single intravenous injection of zymosan-treated neutrophils
title_full	Formation of sustained antitumor effect in mice’s liver and spleen (CBA х C57BL/6)F1 after a single intravenous injection of zymosan-treated neutrophils
title_fullStr	Formation of sustained antitumor effect in mice’s liver and spleen (CBA х C57BL/6)F1 after a single intravenous injection of zymosan-treated neutrophils
title_full_unstemmed	Formation of sustained antitumor effect in mice’s liver and spleen (CBA х C57BL/6)F1 after a single intravenous injection of zymosan-treated neutrophils
title_sort	formation of sustained antitumor effect in mice’s liver and spleen (cba х c57bl/6)f1 after a single intravenous injection of zymosan-treated neutrophils
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2016
url	https://doaj.org/article/820d9422bfb04e079b7c77e941d3681f
work_keys_str_mv	AT aglyubimov formationofsustainedantitumoreffectinmicesliverandspleencbahc57bl6f1afterasingleintravenousinjectionofzymosantreatedneutrophils AT gylyubimov formationofsustainedantitumoreffectinmicesliverandspleencbahc57bl6f1afterasingleintravenousinjectionofzymosantreatedneutrophils AT vakozlov formationofsustainedantitumoreffectinmicesliverandspleencbahc57bl6f1afterasingleintravenousinjectionofzymosantreatedneutrophils
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Formation of sustained antitumor effect in mice’s liver and spleen (CBA х C57BL/6)F1 after a single intravenous injection of zymosan-treated neutrophils

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