Progress in antiretroviral drug delivery using nanotechnology

Rama Mallipeddi, Lisa Cencia RohanUniversity of Pittsburgh, Department of Pharmaceutical Sciences, School of Pharmacy, Magee Womens Research Institute, Pittsburgh, PA, USAAbstract: There are currently a number of antiretroviral drugs that have been approved by the Food and Drug Administration for us...

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Autores principales:	Rama Mallipeddi, Lisa Cencia Rohan
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2010
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/8210bddb22a2471085934cd62f08faf8
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spelling	oai:doaj.org-article:8210bddb22a2471085934cd62f08faf82021-12-02T02:48:32ZProgress in antiretroviral drug delivery using nanotechnology1176-91141178-2013https://doaj.org/article/8210bddb22a2471085934cd62f08faf82010-07-01T00:00:00Zhttp://www.dovepress.com/progress-in-antiretroviral-drug-delivery-using-nanotechnology-a4896https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Rama Mallipeddi, Lisa Cencia RohanUniversity of Pittsburgh, Department of Pharmaceutical Sciences, School of Pharmacy, Magee Womens Research Institute, Pittsburgh, PA, USAAbstract: There are currently a number of antiretroviral drugs that have been approved by the Food and Drug Administration for use in the treatment of human immunodeficiency virus (HIV). More recently, antiretrovirals are being evaluated in the clinic for prevention of HIV infection. Due to the challenging nature of treatment and prevention of this disease, the use of nanocarriers to achieve more efficient delivery of antiretroviral drugs has been studied. Various forms of nanocarriers, such as nanoparticles (polymeric, inorganic, and solid lipid), liposomes, polymeric micelles, dendrimers, cyclodextrins, and cell-based nanoformulations have been studied for delivery of drugs intended for HIV prevention or therapy. The aim of this review is to provide a summary of the application of nanocarrier systems to the delivery of anti-HIV drugs, specifically antiretrovirals. For anti-HIV drugs to be effective, adequate distribution to specific sites in the body must be achieved, and effective drug concentrations must be maintained at those sites for the required period of time. Nanocarriers provide a means to overcome cellular and anatomical barriers to drug delivery. Their application in the area of HIV prevention and therapy may lead to the development of more effective drug products for combating this pandemic disease.Keywords: drug delivery, HIV, antiretrovirals, nanoparticles, liposomes, dendrimers Rama MallipeddiLisa Cencia RohanDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2010, Iss default, Pp 533-547 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Rama Mallipeddi Lisa Cencia Rohan Progress in antiretroviral drug delivery using nanotechnology
description	Rama Mallipeddi, Lisa Cencia RohanUniversity of Pittsburgh, Department of Pharmaceutical Sciences, School of Pharmacy, Magee Womens Research Institute, Pittsburgh, PA, USAAbstract: There are currently a number of antiretroviral drugs that have been approved by the Food and Drug Administration for use in the treatment of human immunodeficiency virus (HIV). More recently, antiretrovirals are being evaluated in the clinic for prevention of HIV infection. Due to the challenging nature of treatment and prevention of this disease, the use of nanocarriers to achieve more efficient delivery of antiretroviral drugs has been studied. Various forms of nanocarriers, such as nanoparticles (polymeric, inorganic, and solid lipid), liposomes, polymeric micelles, dendrimers, cyclodextrins, and cell-based nanoformulations have been studied for delivery of drugs intended for HIV prevention or therapy. The aim of this review is to provide a summary of the application of nanocarrier systems to the delivery of anti-HIV drugs, specifically antiretrovirals. For anti-HIV drugs to be effective, adequate distribution to specific sites in the body must be achieved, and effective drug concentrations must be maintained at those sites for the required period of time. Nanocarriers provide a means to overcome cellular and anatomical barriers to drug delivery. Their application in the area of HIV prevention and therapy may lead to the development of more effective drug products for combating this pandemic disease.Keywords: drug delivery, HIV, antiretrovirals, nanoparticles, liposomes, dendrimers
format	article
author	Rama Mallipeddi Lisa Cencia Rohan
author_facet	Rama Mallipeddi Lisa Cencia Rohan
author_sort	Rama Mallipeddi
title	Progress in antiretroviral drug delivery using nanotechnology
title_short	Progress in antiretroviral drug delivery using nanotechnology
title_full	Progress in antiretroviral drug delivery using nanotechnology
title_fullStr	Progress in antiretroviral drug delivery using nanotechnology
title_full_unstemmed	Progress in antiretroviral drug delivery using nanotechnology
title_sort	progress in antiretroviral drug delivery using nanotechnology
publisher	Dove Medical Press
publishDate	2010
url	https://doaj.org/article/8210bddb22a2471085934cd62f08faf8
work_keys_str_mv	AT ramamallipeddi progressinantiretroviraldrugdeliveryusingnanotechnology AT lisacenciarohan progressinantiretroviraldrugdeliveryusingnanotechnology
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Progress in antiretroviral drug delivery using nanotechnology

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