Outcomes of COVID-19 patients intubated after failure of non-invasive ventilation: a multicenter observational study

Abstract The efficacy of non-invasive ventilation (NIV) in acute respiratory failure secondary to SARS-CoV-2 infection remains controversial. Current literature mainly examined efficacy, safety and potential predictors of NIV failure provided out of the intensive care unit (ICU). On the contrary, th...

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Autores principales:	Annalisa Boscolo, Laura Pasin, Nicolò Sella, Chiara Pretto, Martina Tocco, Enrico Tamburini, Paolo Rosi, Enrico Polati, Katia Donadello, Leonardo Gottin, Andrea Vianello, Giovanni Landoni, Paolo Navalesi, FERS, for the COVID-19 VENETO ICU Network
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8211c0d1a9934999b23b99c5d8e56cdb
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spelling	oai:doaj.org-article:8211c0d1a9934999b23b99c5d8e56cdb2021-12-02T14:58:48ZOutcomes of COVID-19 patients intubated after failure of non-invasive ventilation: a multicenter observational study10.1038/s41598-021-96762-12045-2322https://doaj.org/article/8211c0d1a9934999b23b99c5d8e56cdb2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-96762-1https://doaj.org/toc/2045-2322Abstract The efficacy of non-invasive ventilation (NIV) in acute respiratory failure secondary to SARS-CoV-2 infection remains controversial. Current literature mainly examined efficacy, safety and potential predictors of NIV failure provided out of the intensive care unit (ICU). On the contrary, the outcomes of ICU patients, intubated after NIV failure, remain to be explored. The aims of the present study are: (1) investigating in-hospital mortality in coronavirus disease 2019 (COVID-19) ICU patients receiving endotracheal intubation after NIV failure and (2) assessing whether the length of NIV application affects patient survival. This observational multicenter study included all consecutive COVID-19 adult patients, admitted into the twenty-five ICUs of the COVID-19 VENETO ICU network (February–April 2020), who underwent endotracheal intubation after NIV failure. Among the 704 patients admitted to ICU during the study period, 280 (40%) presented the inclusion criteria and were enrolled. The median age was 69 [60–76] years; 219 patients (78%) were male. In-hospital mortality was 43%. Only the length of NIV application before ICU admission (OR 2.03 (95% CI 1.06–4.98), p = 0.03) and age (OR 1.18 (95% CI 1.04–1.33), p < 0.01) were identified as independent risk factors of in-hospital mortality; whilst the length of NIV after ICU admission did not affect patient outcome. In-hospital mortality of ICU patients intubated after NIV failure was 43%. Days on NIV before ICU admission and age were assessed to be potential risk factors of greater in-hospital mortality.Annalisa BoscoloLaura PasinNicolò SellaChiara PrettoMartina ToccoEnrico TamburiniPaolo RosiEnrico PolatiKatia DonadelloLeonardo GottinAndrea VianelloGiovanni LandoniPaolo NavalesiFERS, for the COVID-19 VENETO ICU NetworkNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Annalisa Boscolo Laura Pasin Nicolò Sella Chiara Pretto Martina Tocco Enrico Tamburini Paolo Rosi Enrico Polati Katia Donadello Leonardo Gottin Andrea Vianello Giovanni Landoni Paolo Navalesi FERS, for the COVID-19 VENETO ICU Network Outcomes of COVID-19 patients intubated after failure of non-invasive ventilation: a multicenter observational study
description	Abstract The efficacy of non-invasive ventilation (NIV) in acute respiratory failure secondary to SARS-CoV-2 infection remains controversial. Current literature mainly examined efficacy, safety and potential predictors of NIV failure provided out of the intensive care unit (ICU). On the contrary, the outcomes of ICU patients, intubated after NIV failure, remain to be explored. The aims of the present study are: (1) investigating in-hospital mortality in coronavirus disease 2019 (COVID-19) ICU patients receiving endotracheal intubation after NIV failure and (2) assessing whether the length of NIV application affects patient survival. This observational multicenter study included all consecutive COVID-19 adult patients, admitted into the twenty-five ICUs of the COVID-19 VENETO ICU network (February–April 2020), who underwent endotracheal intubation after NIV failure. Among the 704 patients admitted to ICU during the study period, 280 (40%) presented the inclusion criteria and were enrolled. The median age was 69 [60–76] years; 219 patients (78%) were male. In-hospital mortality was 43%. Only the length of NIV application before ICU admission (OR 2.03 (95% CI 1.06–4.98), p = 0.03) and age (OR 1.18 (95% CI 1.04–1.33), p < 0.01) were identified as independent risk factors of in-hospital mortality; whilst the length of NIV after ICU admission did not affect patient outcome. In-hospital mortality of ICU patients intubated after NIV failure was 43%. Days on NIV before ICU admission and age were assessed to be potential risk factors of greater in-hospital mortality.
format	article
author	Annalisa Boscolo Laura Pasin Nicolò Sella Chiara Pretto Martina Tocco Enrico Tamburini Paolo Rosi Enrico Polati Katia Donadello Leonardo Gottin Andrea Vianello Giovanni Landoni Paolo Navalesi FERS, for the COVID-19 VENETO ICU Network
author_facet	Annalisa Boscolo Laura Pasin Nicolò Sella Chiara Pretto Martina Tocco Enrico Tamburini Paolo Rosi Enrico Polati Katia Donadello Leonardo Gottin Andrea Vianello Giovanni Landoni Paolo Navalesi FERS, for the COVID-19 VENETO ICU Network
author_sort	Annalisa Boscolo
title	Outcomes of COVID-19 patients intubated after failure of non-invasive ventilation: a multicenter observational study
title_short	Outcomes of COVID-19 patients intubated after failure of non-invasive ventilation: a multicenter observational study
title_full	Outcomes of COVID-19 patients intubated after failure of non-invasive ventilation: a multicenter observational study
title_fullStr	Outcomes of COVID-19 patients intubated after failure of non-invasive ventilation: a multicenter observational study
title_full_unstemmed	Outcomes of COVID-19 patients intubated after failure of non-invasive ventilation: a multicenter observational study
title_sort	outcomes of covid-19 patients intubated after failure of non-invasive ventilation: a multicenter observational study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/8211c0d1a9934999b23b99c5d8e56cdb
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Outcomes of COVID-19 patients intubated after failure of non-invasive ventilation: a multicenter observational study

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