Epigenetic regulation of the circadian gene Per1 contributes to age-related changes in hippocampal memory

Circadian rhythms are known to modulate memory, but it’s not known whether clock genes in the hippocampus are required for memory consolidation. Here, the authors show that epigenetic regulation of clock gene Period1 in the hippocampus regulates memory and contributes to age-related memory decline,...

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Autores principales:	Janine L. Kwapis, Yasaman Alaghband, Enikö A. Kramár, Alberto J. López, Annie Vogel Ciernia, André O. White, Guanhua Shu, Diane Rhee, Christina M. Michael, Emilie Montellier, Yu Liu, Christophe N. Magnan, Siwei Chen, Paolo Sassone-Corsi, Pierre Baldi, Dina P. Matheos, Marcelo A. Wood
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8214879eac4444f79329a0009fdad2ee
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spelling	oai:doaj.org-article:8214879eac4444f79329a0009fdad2ee2021-12-02T14:39:07ZEpigenetic regulation of the circadian gene Per1 contributes to age-related changes in hippocampal memory10.1038/s41467-018-05868-02041-1723https://doaj.org/article/8214879eac4444f79329a0009fdad2ee2018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05868-0https://doaj.org/toc/2041-1723Circadian rhythms are known to modulate memory, but it’s not known whether clock genes in the hippocampus are required for memory consolidation. Here, the authors show that epigenetic regulation of clock gene Period1 in the hippocampus regulates memory and contributes to age-related memory decline, independent of circadian rhythms.Janine L. KwapisYasaman AlaghbandEnikö A. KramárAlberto J. LópezAnnie Vogel CierniaAndré O. WhiteGuanhua ShuDiane RheeChristina M. MichaelEmilie MontellierYu LiuChristophe N. MagnanSiwei ChenPaolo Sassone-CorsiPierre BaldiDina P. MatheosMarcelo A. WoodNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Janine L. Kwapis Yasaman Alaghband Enikö A. Kramár Alberto J. López Annie Vogel Ciernia André O. White Guanhua Shu Diane Rhee Christina M. Michael Emilie Montellier Yu Liu Christophe N. Magnan Siwei Chen Paolo Sassone-Corsi Pierre Baldi Dina P. Matheos Marcelo A. Wood Epigenetic regulation of the circadian gene Per1 contributes to age-related changes in hippocampal memory
description	Circadian rhythms are known to modulate memory, but it’s not known whether clock genes in the hippocampus are required for memory consolidation. Here, the authors show that epigenetic regulation of clock gene Period1 in the hippocampus regulates memory and contributes to age-related memory decline, independent of circadian rhythms.
format	article
author	Janine L. Kwapis Yasaman Alaghband Enikö A. Kramár Alberto J. López Annie Vogel Ciernia André O. White Guanhua Shu Diane Rhee Christina M. Michael Emilie Montellier Yu Liu Christophe N. Magnan Siwei Chen Paolo Sassone-Corsi Pierre Baldi Dina P. Matheos Marcelo A. Wood
author_facet	Janine L. Kwapis Yasaman Alaghband Enikö A. Kramár Alberto J. López Annie Vogel Ciernia André O. White Guanhua Shu Diane Rhee Christina M. Michael Emilie Montellier Yu Liu Christophe N. Magnan Siwei Chen Paolo Sassone-Corsi Pierre Baldi Dina P. Matheos Marcelo A. Wood
author_sort	Janine L. Kwapis
title	Epigenetic regulation of the circadian gene Per1 contributes to age-related changes in hippocampal memory
title_short	Epigenetic regulation of the circadian gene Per1 contributes to age-related changes in hippocampal memory
title_full	Epigenetic regulation of the circadian gene Per1 contributes to age-related changes in hippocampal memory
title_fullStr	Epigenetic regulation of the circadian gene Per1 contributes to age-related changes in hippocampal memory
title_full_unstemmed	Epigenetic regulation of the circadian gene Per1 contributes to age-related changes in hippocampal memory
title_sort	epigenetic regulation of the circadian gene per1 contributes to age-related changes in hippocampal memory
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/8214879eac4444f79329a0009fdad2ee
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Epigenetic regulation of the circadian gene Per1 contributes to age-related changes in hippocampal memory

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