The clinical usefulness of central hemodynamics to evaluate diastolic dysfunction in subjects without hypertension

GeeHee Kim,1 Ji-Hoon Kim,1 Keon-Woong Moon,1 Ki-Dong Yoo,1 Sang-Hyun Ihm,2 Ho-Joong Youn,2 Chul-Min Kim11Division of Cardiology, Department of Internal Medicine, St Vincent's Hospital, Catholic University of Korea, Suwon, 2Division of Cardiology, Department of Internal Medicine, School of Me...

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Autores principales:	Kim GH, Kim JH, Moon KW, Yoo KD, Ihm SH, Youn HJ, Kim CM
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	central blood pressure augmentation index diastolic dysfunction Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/82166f0ebcb745c2a29e877fd8a9f2bd
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spelling	oai:doaj.org-article:82166f0ebcb745c2a29e877fd8a9f2bd2021-12-02T04:12:59ZThe clinical usefulness of central hemodynamics to evaluate diastolic dysfunction in subjects without hypertension1178-1998https://doaj.org/article/82166f0ebcb745c2a29e877fd8a9f2bd2014-03-01T00:00:00Zhttps://www.dovepress.com/the-clinical-usefulness-of-central-hemodynamics-to-evaluate-diastolic--peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998GeeHee Kim,1 Ji-Hoon Kim,1 Keon-Woong Moon,1 Ki-Dong Yoo,1 Sang-Hyun Ihm,2 Ho-Joong Youn,2 Chul-Min Kim11Division of Cardiology, Department of Internal Medicine, St Vincent's Hospital, Catholic University of Korea, Suwon, 2Division of Cardiology, Department of Internal Medicine, School of Medicine, Catholic University of Korea, Seoul, South KoreaObjective: Diastolic dysfunction is associated with increased arterial stiffness in patients with hypertension. However, the role of arterial stiffness in diastolic dysfunction in subjects without hypertension has not been fully established.Materials and methods: A total of 287 subjects (male:female ratio 121:166, mean age 53.0±14.4 years) without hypertension or any heart disease who simultaneously received transthoracic echocardiography and noninvasively semiautomated radial artery applanation tonometry (with an Omron HEM-9000AI) in the Department of Internal Medicine, St Vincent’s Hospital, from July 2011 to September 2012, were enrolled in this study.Results: A total of 147 subjects (male:female ratio 59:88, mean age 61.7±9.9 years), representing 51.2% of the 287 subjects, had diastolic dysfunction (defined as abnormal relaxation pattern of mitral inflow). There were significant differences in systolic blood pressure (BP), pulse pressure, late systolic peak pressure (SBP2), and radial augmentation index (RaAIx) between normal diastolic function and diastolic dysfunction. ΔBP was defined as systolic BP minus SBP2, because of the difference in systolic BP between the two groups. ΔBP (odds ratio [OR] 1.059, 95% confidence interval [CI] 1.005–1.115; P=0.032) and RaAIx (odds ratio 1.027, 95% CI 1.009–1.044, P=0.003) were associated with diastolic dysfunction. A receiver operating-characteristic curve showed that ΔBP (area under the curve 0.875, 95% CI 0.832–0.911) and RaAIx (area under the curve 0.878, 95% CI 0.835–0.914) were associated with diastolic dysfunction.Conclusion: We found that ΔBP and increased RaAIx were associated with diastolic dysfunction in subjects without hypertension after adjustment for age and sex. Therefore, it is suggested that noninvasive estimation of central BP may be useful to reflect diastolic dysfunction in subjects with normal peripheral BP.Keywords: central blood pressure, augmentation index, diastolic dysfunctionKim GHKim JHMoon KWYoo KDIhm SHYoun HJKim CMDove Medical Pressarticlecentral blood pressureaugmentation indexdiastolic dysfunctionGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 9, Pp 527-533 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	central blood pressure augmentation index diastolic dysfunction Geriatrics RC952-954.6
spellingShingle	central blood pressure augmentation index diastolic dysfunction Geriatrics RC952-954.6 Kim GH Kim JH Moon KW Yoo KD Ihm SH Youn HJ Kim CM The clinical usefulness of central hemodynamics to evaluate diastolic dysfunction in subjects without hypertension
description	GeeHee Kim,1 Ji-Hoon Kim,1 Keon-Woong Moon,1 Ki-Dong Yoo,1 Sang-Hyun Ihm,2 Ho-Joong Youn,2 Chul-Min Kim11Division of Cardiology, Department of Internal Medicine, St Vincent's Hospital, Catholic University of Korea, Suwon, 2Division of Cardiology, Department of Internal Medicine, School of Medicine, Catholic University of Korea, Seoul, South KoreaObjective: Diastolic dysfunction is associated with increased arterial stiffness in patients with hypertension. However, the role of arterial stiffness in diastolic dysfunction in subjects without hypertension has not been fully established.Materials and methods: A total of 287 subjects (male:female ratio 121:166, mean age 53.0±14.4 years) without hypertension or any heart disease who simultaneously received transthoracic echocardiography and noninvasively semiautomated radial artery applanation tonometry (with an Omron HEM-9000AI) in the Department of Internal Medicine, St Vincent’s Hospital, from July 2011 to September 2012, were enrolled in this study.Results: A total of 147 subjects (male:female ratio 59:88, mean age 61.7±9.9 years), representing 51.2% of the 287 subjects, had diastolic dysfunction (defined as abnormal relaxation pattern of mitral inflow). There were significant differences in systolic blood pressure (BP), pulse pressure, late systolic peak pressure (SBP2), and radial augmentation index (RaAIx) between normal diastolic function and diastolic dysfunction. ΔBP was defined as systolic BP minus SBP2, because of the difference in systolic BP between the two groups. ΔBP (odds ratio [OR] 1.059, 95% confidence interval [CI] 1.005–1.115; P=0.032) and RaAIx (odds ratio 1.027, 95% CI 1.009–1.044, P=0.003) were associated with diastolic dysfunction. A receiver operating-characteristic curve showed that ΔBP (area under the curve 0.875, 95% CI 0.832–0.911) and RaAIx (area under the curve 0.878, 95% CI 0.835–0.914) were associated with diastolic dysfunction.Conclusion: We found that ΔBP and increased RaAIx were associated with diastolic dysfunction in subjects without hypertension after adjustment for age and sex. Therefore, it is suggested that noninvasive estimation of central BP may be useful to reflect diastolic dysfunction in subjects with normal peripheral BP.Keywords: central blood pressure, augmentation index, diastolic dysfunction
format	article
author	Kim GH Kim JH Moon KW Yoo KD Ihm SH Youn HJ Kim CM
author_facet	Kim GH Kim JH Moon KW Yoo KD Ihm SH Youn HJ Kim CM
author_sort	Kim GH
title	The clinical usefulness of central hemodynamics to evaluate diastolic dysfunction in subjects without hypertension
title_short	The clinical usefulness of central hemodynamics to evaluate diastolic dysfunction in subjects without hypertension
title_full	The clinical usefulness of central hemodynamics to evaluate diastolic dysfunction in subjects without hypertension
title_fullStr	The clinical usefulness of central hemodynamics to evaluate diastolic dysfunction in subjects without hypertension
title_full_unstemmed	The clinical usefulness of central hemodynamics to evaluate diastolic dysfunction in subjects without hypertension
title_sort	clinical usefulness of central hemodynamics to evaluate diastolic dysfunction in subjects without hypertension
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/82166f0ebcb745c2a29e877fd8a9f2bd
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The clinical usefulness of central hemodynamics to evaluate diastolic dysfunction in subjects without hypertension

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