Relationship between Rab and insulin-like proteins in the nervous system of Bombyx mori
Rab proteins are small GTP-binding proteins and are the largest family in the Ras GTPase superfamily and mediate vesicular transport in cells. Diverse insulin-like peptides, such as bombyxin, are synthesized in the brain and secreted into the haemolymph by the corpus allatum (CA). In the brain of Bo...
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Institute of Entomology, Biology Centre, Czech Academy of Science
2021
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oai:doaj.org-article:82167effb8b6426a90f32fd942c984042021-11-05T15:23:15ZRelationship between Rab and insulin-like proteins in the nervous system of Bombyx mori1210-57591802-882910.14411/eje.2021.031https://doaj.org/article/82167effb8b6426a90f32fd942c984042021-10-01T00:00:00Zhttps://www.eje.cz/artkey/eje-202101-0031_relationship_between_rab_and_insulin-like_proteins_in_the_nervous_system_of_bombyx_mori.phphttps://doaj.org/toc/1210-5759https://doaj.org/toc/1802-8829Rab proteins are small GTP-binding proteins and are the largest family in the Ras GTPase superfamily and mediate vesicular transport in cells. Diverse insulin-like peptides, such as bombyxin, are synthesized in the brain and secreted into the haemolymph by the corpus allatum (CA). In the brain of Bombyx mori, Rabs are expressed in a specific area; however, which Rabs actually link the secretion of bombyxin remains unknown. A double-staining analysis of nine Rabs (Rab1, 3, 6, 7, 14, 21, 26, 39 and X4) and bombyxin indicated that Rab3-, Rab7-, Rab39- and RabX4-immunohistochemical reactivity (ir) areas overlapped with bombyxin-ir in the brain and CA in B. mori, while Rab6-, Rab14- and Rab21-irs partially overlapped in the CA. Rab1-ir occurred in the other immunopositive areas in CA. Rab26-ir did not occur in the brain. Rab39-ir occurred in UNC104, Rab39- effector, -immunopositive neurons in the brain and CA. Thus, Rab3, 7, 39 and X4 may regulate the exocytosis of bombyxin.Tomohide UNOYusuke OZAKIYAMako SASAOKatsuhiko SAKAMOTOYasuo YAMAUCHIYuichi UNOKengo KANAMARUAkira MIZOGUCHIInstitute of Entomology, Biology Centre, Czech Academy of Sciencearticlelepidopterabombyx morilarvarab proteinsbombyxinbraincorpus allatumZoologyQL1-991ENEuropean Journal of Entomology, Vol 118, Iss 1, Pp 307-314 (2021) |
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| collection |
DOAJ |
| language |
EN |
| topic |
lepidoptera bombyx mori larva rab proteins bombyxin brain corpus allatum Zoology QL1-991 |
| spellingShingle |
lepidoptera bombyx mori larva rab proteins bombyxin brain corpus allatum Zoology QL1-991 Tomohide UNO Yusuke OZAKIYA Mako SASAO Katsuhiko SAKAMOTO Yasuo YAMAUCHI Yuichi UNO Kengo KANAMARU Akira MIZOGUCHI Relationship between Rab and insulin-like proteins in the nervous system of Bombyx mori |
| description |
Rab proteins are small GTP-binding proteins and are the largest family in the Ras GTPase superfamily and mediate vesicular transport in cells. Diverse insulin-like peptides, such as bombyxin, are synthesized in the brain and secreted into the haemolymph by the corpus allatum (CA). In the brain of Bombyx mori, Rabs are expressed in a specific area; however, which Rabs actually link the secretion of bombyxin remains unknown. A double-staining analysis of nine Rabs (Rab1, 3, 6, 7, 14, 21, 26, 39 and X4) and bombyxin indicated that Rab3-, Rab7-, Rab39- and RabX4-immunohistochemical reactivity (ir) areas overlapped with bombyxin-ir in the brain and CA in B. mori, while Rab6-, Rab14- and Rab21-irs partially overlapped in the CA. Rab1-ir occurred in the other immunopositive areas in CA. Rab26-ir did not occur in the brain. Rab39-ir occurred in UNC104, Rab39- effector, -immunopositive neurons in the brain and CA. Thus, Rab3, 7, 39 and X4 may regulate the exocytosis of bombyxin. |
| format |
article |
| author |
Tomohide UNO Yusuke OZAKIYA Mako SASAO Katsuhiko SAKAMOTO Yasuo YAMAUCHI Yuichi UNO Kengo KANAMARU Akira MIZOGUCHI |
| author_facet |
Tomohide UNO Yusuke OZAKIYA Mako SASAO Katsuhiko SAKAMOTO Yasuo YAMAUCHI Yuichi UNO Kengo KANAMARU Akira MIZOGUCHI |
| author_sort |
Tomohide UNO |
| title |
Relationship between Rab and insulin-like proteins in the nervous system of Bombyx mori |
| title_short |
Relationship between Rab and insulin-like proteins in the nervous system of Bombyx mori |
| title_full |
Relationship between Rab and insulin-like proteins in the nervous system of Bombyx mori |
| title_fullStr |
Relationship between Rab and insulin-like proteins in the nervous system of Bombyx mori |
| title_full_unstemmed |
Relationship between Rab and insulin-like proteins in the nervous system of Bombyx mori |
| title_sort |
relationship between rab and insulin-like proteins in the nervous system of bombyx mori |
| publisher |
Institute of Entomology, Biology Centre, Czech Academy of Science |
| publishDate |
2021 |
| url |
https://doaj.org/article/82167effb8b6426a90f32fd942c98404 |
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