PRMT3 interacts with ALDH1A1 and regulates gene-expression by inhibiting retinoic acid signaling

Here, the authors demonstrate that protein arginine methyltransferase 3 (PRMT3) interacts with and inhibits the retinal dehydrogenase ALDH1A1, negatively regulating the expression of retinoic acid responsive genes. This study shows that PRMT3 affects diverse biological processes not only by globally...

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Autores principales:	Mamta Verma, Mohd. Imran K. Khan, Rajashekar Varma Kadumuri, Baskar Chakrapani, Sharad Awasthi, Arun Mahesh, Gayathri Govindaraju, Pavithra L Chavali, Arumugam Rajavelu, Sreenivas Chavali, Arunkumar Dhayalan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/8217d811b7904b0782645e59d929fb2e
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spelling	oai:doaj.org-article:8217d811b7904b0782645e59d929fb2e2021-12-02T13:57:58ZPRMT3 interacts with ALDH1A1 and regulates gene-expression by inhibiting retinoic acid signaling10.1038/s42003-020-01644-32399-3642https://doaj.org/article/8217d811b7904b0782645e59d929fb2e2021-01-01T00:00:00Zhttps://doi.org/10.1038/s42003-020-01644-3https://doaj.org/toc/2399-3642Here, the authors demonstrate that protein arginine methyltransferase 3 (PRMT3) interacts with and inhibits the retinal dehydrogenase ALDH1A1, negatively regulating the expression of retinoic acid responsive genes. This study shows that PRMT3 affects diverse biological processes not only by globally regulating protein function through methylation but also by regulating gene expression.Mamta VermaMohd. Imran K. KhanRajashekar Varma KadumuriBaskar ChakrapaniSharad AwasthiArun MaheshGayathri GovindarajuPavithra L ChavaliArumugam RajaveluSreenivas ChavaliArunkumar DhayalanNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Mamta Verma Mohd. Imran K. Khan Rajashekar Varma Kadumuri Baskar Chakrapani Sharad Awasthi Arun Mahesh Gayathri Govindaraju Pavithra L Chavali Arumugam Rajavelu Sreenivas Chavali Arunkumar Dhayalan PRMT3 interacts with ALDH1A1 and regulates gene-expression by inhibiting retinoic acid signaling
description	Here, the authors demonstrate that protein arginine methyltransferase 3 (PRMT3) interacts with and inhibits the retinal dehydrogenase ALDH1A1, negatively regulating the expression of retinoic acid responsive genes. This study shows that PRMT3 affects diverse biological processes not only by globally regulating protein function through methylation but also by regulating gene expression.
format	article
author	Mamta Verma Mohd. Imran K. Khan Rajashekar Varma Kadumuri Baskar Chakrapani Sharad Awasthi Arun Mahesh Gayathri Govindaraju Pavithra L Chavali Arumugam Rajavelu Sreenivas Chavali Arunkumar Dhayalan
author_facet	Mamta Verma Mohd. Imran K. Khan Rajashekar Varma Kadumuri Baskar Chakrapani Sharad Awasthi Arun Mahesh Gayathri Govindaraju Pavithra L Chavali Arumugam Rajavelu Sreenivas Chavali Arunkumar Dhayalan
author_sort	Mamta Verma
title	PRMT3 interacts with ALDH1A1 and regulates gene-expression by inhibiting retinoic acid signaling
title_short	PRMT3 interacts with ALDH1A1 and regulates gene-expression by inhibiting retinoic acid signaling
title_full	PRMT3 interacts with ALDH1A1 and regulates gene-expression by inhibiting retinoic acid signaling
title_fullStr	PRMT3 interacts with ALDH1A1 and regulates gene-expression by inhibiting retinoic acid signaling
title_full_unstemmed	PRMT3 interacts with ALDH1A1 and regulates gene-expression by inhibiting retinoic acid signaling
title_sort	prmt3 interacts with aldh1a1 and regulates gene-expression by inhibiting retinoic acid signaling
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/8217d811b7904b0782645e59d929fb2e
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PRMT3 interacts with ALDH1A1 and regulates gene-expression by inhibiting retinoic acid signaling

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