NIR fluorescence-guided tumor surgery: new strategies for the use of indocyanine green

Claire Egloff-Juras,1,2 Lina Bezdetnaya,1,3 Gilles Dolivet,1,3 Henri-Pierre Lassalle1,3 1Université de Lorraine, CNRS, CRAN, Nancy F-54000, France; 2Université de Lorraine, CHRU-Nancy, Institut de Cancérologie de Lorraine, Nancy F-54000, France; 3Institut de Cancérologie de L...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Egloff-Juras C, Bezdetnaya L, Dolivet G, Lassalle HP
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2019
Materias:
Acceso en línea:https://doaj.org/article/821a3d36bb0e44a999b4eed4f3ce7828
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:821a3d36bb0e44a999b4eed4f3ce7828
record_format dspace
spelling oai:doaj.org-article:821a3d36bb0e44a999b4eed4f3ce78282021-12-02T04:40:50ZNIR fluorescence-guided tumor surgery: new strategies for the use of indocyanine green1178-2013https://doaj.org/article/821a3d36bb0e44a999b4eed4f3ce78282019-09-01T00:00:00Zhttps://www.dovepress.com/nir-fluorescence-guided-tumor-surgery-new-strategies-for-the-use-of-in-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Claire Egloff-Juras,1,2 Lina Bezdetnaya,1,3 Gilles Dolivet,1,3 Henri-Pierre Lassalle1,3 1Université de Lorraine, CNRS, CRAN, Nancy F-54000, France; 2Université de Lorraine, CHRU-Nancy, Institut de Cancérologie de Lorraine, Nancy F-54000, France; 3Institut de Cancérologie de Lorraine, Nancy F-54000, FranceCorrespondence: Claire Egloff-JurasFaculté d’Odontologie de Lorraine, Université de Lorraine, 7 Avenue de la Forêt de Haye, Vandoeuvre-lès-Nancy, Nancy 54500, FranceTel +33 37 274 6760Email claire.juras@univ-lorraine.frAbstract: Surgery is the frontline treatment for a large number of cancers. The objective of these excisional surgeries is the complete removal of the primary tumor with sufficient safety margins. Removal of the entire tumor is essential to improve the chances of a full recovery. To help surgeons achieve this objective, near-infrared fluorescence-guided surgical techniques are of great interest. The concomitant use of fluorescence and indocyanine green (ICG) has proved effective in the identification and characterization of tumors. Moreover, ICG is authorized by the Food and Drug Administration and the European Medicines Agency and is therefore the subject of a large number of studies. ICG is one of the most commonly used fluorophores in near-infrared fluorescence-guided techniques. However, it also has some disadvantages, such as limited photostability, a moderate fluorescence quantum yield, a high plasma protein binding rate, and undesired aggregation in aqueous solution. In addition, ICG does not specifically target tumor cells. One way to exploit the capabilities of ICG while offsetting these drawbacks is to develop high-performance near-infrared nanocomplexes formulated with ICG (with high selectivity for tumors, high tumor-to-background ratios, and minimal toxicity). In this review article, we focus on recent developments in ICG complexation strategies to improve near-infrared fluorescence-guided tumor surgery. We describe targeted and nontargeted ICG nanoparticle models and ICG complexation with targeting agents.Keywords: near-infrared fluorescence-guided surgery, indocyanine green, nanoparticle, targeted nanoparticle, ICG complexationEgloff-Juras CBezdetnaya LDolivet GLassalle HPDove Medical PressarticleNear-infrared fluorescence-guided surgeryindocyanine greennanoparticletargeted nanoparticleICG complexationMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 14, Pp 7823-7838 (2019)
institution DOAJ
collection DOAJ
language EN
topic Near-infrared fluorescence-guided surgery
indocyanine green
nanoparticle
targeted nanoparticle
ICG complexation
Medicine (General)
R5-920
spellingShingle Near-infrared fluorescence-guided surgery
indocyanine green
nanoparticle
targeted nanoparticle
ICG complexation
Medicine (General)
R5-920
Egloff-Juras C
Bezdetnaya L
Dolivet G
Lassalle HP
NIR fluorescence-guided tumor surgery: new strategies for the use of indocyanine green
description Claire Egloff-Juras,1,2 Lina Bezdetnaya,1,3 Gilles Dolivet,1,3 Henri-Pierre Lassalle1,3 1Université de Lorraine, CNRS, CRAN, Nancy F-54000, France; 2Université de Lorraine, CHRU-Nancy, Institut de Cancérologie de Lorraine, Nancy F-54000, France; 3Institut de Cancérologie de Lorraine, Nancy F-54000, FranceCorrespondence: Claire Egloff-JurasFaculté d’Odontologie de Lorraine, Université de Lorraine, 7 Avenue de la Forêt de Haye, Vandoeuvre-lès-Nancy, Nancy 54500, FranceTel +33 37 274 6760Email claire.juras@univ-lorraine.frAbstract: Surgery is the frontline treatment for a large number of cancers. The objective of these excisional surgeries is the complete removal of the primary tumor with sufficient safety margins. Removal of the entire tumor is essential to improve the chances of a full recovery. To help surgeons achieve this objective, near-infrared fluorescence-guided surgical techniques are of great interest. The concomitant use of fluorescence and indocyanine green (ICG) has proved effective in the identification and characterization of tumors. Moreover, ICG is authorized by the Food and Drug Administration and the European Medicines Agency and is therefore the subject of a large number of studies. ICG is one of the most commonly used fluorophores in near-infrared fluorescence-guided techniques. However, it also has some disadvantages, such as limited photostability, a moderate fluorescence quantum yield, a high plasma protein binding rate, and undesired aggregation in aqueous solution. In addition, ICG does not specifically target tumor cells. One way to exploit the capabilities of ICG while offsetting these drawbacks is to develop high-performance near-infrared nanocomplexes formulated with ICG (with high selectivity for tumors, high tumor-to-background ratios, and minimal toxicity). In this review article, we focus on recent developments in ICG complexation strategies to improve near-infrared fluorescence-guided tumor surgery. We describe targeted and nontargeted ICG nanoparticle models and ICG complexation with targeting agents.Keywords: near-infrared fluorescence-guided surgery, indocyanine green, nanoparticle, targeted nanoparticle, ICG complexation
format article
author Egloff-Juras C
Bezdetnaya L
Dolivet G
Lassalle HP
author_facet Egloff-Juras C
Bezdetnaya L
Dolivet G
Lassalle HP
author_sort Egloff-Juras C
title NIR fluorescence-guided tumor surgery: new strategies for the use of indocyanine green
title_short NIR fluorescence-guided tumor surgery: new strategies for the use of indocyanine green
title_full NIR fluorescence-guided tumor surgery: new strategies for the use of indocyanine green
title_fullStr NIR fluorescence-guided tumor surgery: new strategies for the use of indocyanine green
title_full_unstemmed NIR fluorescence-guided tumor surgery: new strategies for the use of indocyanine green
title_sort nir fluorescence-guided tumor surgery: new strategies for the use of indocyanine green
publisher Dove Medical Press
publishDate 2019
url https://doaj.org/article/821a3d36bb0e44a999b4eed4f3ce7828
work_keys_str_mv AT egloffjurasc nirfluorescenceguidedtumorsurgerynewstrategiesfortheuseofindocyaninegreen
AT bezdetnayal nirfluorescenceguidedtumorsurgerynewstrategiesfortheuseofindocyaninegreen
AT dolivetg nirfluorescenceguidedtumorsurgerynewstrategiesfortheuseofindocyaninegreen
AT lassallehp nirfluorescenceguidedtumorsurgerynewstrategiesfortheuseofindocyaninegreen
_version_ 1718401130753425408