IFNα serum levels are associated with endothelial progenitor cells imbalance and disease features in rheumatoid arthritis patients.

<h4>Introduction</h4>IFNα has been largely implicated in the ethiopathogenesis of autoimmune diseases but only recently it has been linked to endothelial damage and accelerated atherosclerosis in autoimmunity. In addition, proinflammatory conditions are supposed to be implicated in the c...

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Autores principales:	Javier Rodríguez-Carrio, Banesa de Paz, Patricia López, Catuxa Prado, Mercedes Alperi-López, Francisco Javier Ballina-García, Ana Suárez
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8226036b28af416bbae813fb4d1708f4
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spelling	oai:doaj.org-article:8226036b28af416bbae813fb4d1708f42021-11-18T08:36:52ZIFNα serum levels are associated with endothelial progenitor cells imbalance and disease features in rheumatoid arthritis patients.1932-620310.1371/journal.pone.0086069https://doaj.org/article/8226036b28af416bbae813fb4d1708f42014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24465874/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Introduction</h4>IFNα has been largely implicated in the ethiopathogenesis of autoimmune diseases but only recently it has been linked to endothelial damage and accelerated atherosclerosis in autoimmunity. In addition, proinflammatory conditions are supposed to be implicated in the cardiovascular status of these patients. Since a role for IFNα in endothelial damage and impaired Endothelial Progenitor Cell (EPC) number and function has been reported in other diseases, we aimed to evaluate the potential associations of IFNα serum levels on EPC populations and cytokine profiles in Rheumatoid Arthritis (RA) patients.<h4>Methods</h4>pre-EPC, EPC and mature EPC (mEPC) populations were quantified by flow cytometry analyzing their differential CD34, CD133 and VEGFR2 expression in blood samples from 120 RA patients, 52 healthy controls (HC), and 83 systemic lupus erythematosus (SLE) patients as disease control. Cytokine serum levels were measured by immunoassays and clinical and immunological data, including cardiovascular (CV) events and CV risk factors, were retrospectively obtained by reviewing clinical records.<h4>Results</h4>Long-standing, but not recent onset RA patients displayed a significant depletion of all endothelial progenitor populations, unless high IFNα levels were present. In fact, the IFN(high) RA patient group (n = 40, 33%), showed increased EPC levels, comparable to SLE patients. In addition, high IFNα serum levels were associated with higher disease activity (DAS28), presence of autoantibodies, higher levels of IL-1β, IL-6, IL-10 and MIP-1α, lower amounts of TGF-β, and increased mEPC/EPC ratio, thus suggesting higher rates of endothelial damage and an endothelial repair failure. Finally, the relationship between high IFNα levels and occurrence of CV events observed in RA patients seems to support this hypothesis.<h4>Conclusions</h4>IFNα serum marker could be used to identify a group of RA patients with increased disease activity, EPC imbalance, enhanced proinflammatory profile and higher cardiovascular risk, probably due, at least in part, to an impaired endothelial repair.Javier Rodríguez-CarrioBanesa de PazPatricia LópezCatuxa PradoMercedes Alperi-LópezFrancisco Javier Ballina-GarcíaAna SuárezPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 1, p e86069 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Javier Rodríguez-Carrio Banesa de Paz Patricia López Catuxa Prado Mercedes Alperi-López Francisco Javier Ballina-García Ana Suárez IFNα serum levels are associated with endothelial progenitor cells imbalance and disease features in rheumatoid arthritis patients.
description	<h4>Introduction</h4>IFNα has been largely implicated in the ethiopathogenesis of autoimmune diseases but only recently it has been linked to endothelial damage and accelerated atherosclerosis in autoimmunity. In addition, proinflammatory conditions are supposed to be implicated in the cardiovascular status of these patients. Since a role for IFNα in endothelial damage and impaired Endothelial Progenitor Cell (EPC) number and function has been reported in other diseases, we aimed to evaluate the potential associations of IFNα serum levels on EPC populations and cytokine profiles in Rheumatoid Arthritis (RA) patients.<h4>Methods</h4>pre-EPC, EPC and mature EPC (mEPC) populations were quantified by flow cytometry analyzing their differential CD34, CD133 and VEGFR2 expression in blood samples from 120 RA patients, 52 healthy controls (HC), and 83 systemic lupus erythematosus (SLE) patients as disease control. Cytokine serum levels were measured by immunoassays and clinical and immunological data, including cardiovascular (CV) events and CV risk factors, were retrospectively obtained by reviewing clinical records.<h4>Results</h4>Long-standing, but not recent onset RA patients displayed a significant depletion of all endothelial progenitor populations, unless high IFNα levels were present. In fact, the IFN(high) RA patient group (n = 40, 33%), showed increased EPC levels, comparable to SLE patients. In addition, high IFNα serum levels were associated with higher disease activity (DAS28), presence of autoantibodies, higher levels of IL-1β, IL-6, IL-10 and MIP-1α, lower amounts of TGF-β, and increased mEPC/EPC ratio, thus suggesting higher rates of endothelial damage and an endothelial repair failure. Finally, the relationship between high IFNα levels and occurrence of CV events observed in RA patients seems to support this hypothesis.<h4>Conclusions</h4>IFNα serum marker could be used to identify a group of RA patients with increased disease activity, EPC imbalance, enhanced proinflammatory profile and higher cardiovascular risk, probably due, at least in part, to an impaired endothelial repair.
format	article
author	Javier Rodríguez-Carrio Banesa de Paz Patricia López Catuxa Prado Mercedes Alperi-López Francisco Javier Ballina-García Ana Suárez
author_facet	Javier Rodríguez-Carrio Banesa de Paz Patricia López Catuxa Prado Mercedes Alperi-López Francisco Javier Ballina-García Ana Suárez
author_sort	Javier Rodríguez-Carrio
title	IFNα serum levels are associated with endothelial progenitor cells imbalance and disease features in rheumatoid arthritis patients.
title_short	IFNα serum levels are associated with endothelial progenitor cells imbalance and disease features in rheumatoid arthritis patients.
title_full	IFNα serum levels are associated with endothelial progenitor cells imbalance and disease features in rheumatoid arthritis patients.
title_fullStr	IFNα serum levels are associated with endothelial progenitor cells imbalance and disease features in rheumatoid arthritis patients.
title_full_unstemmed	IFNα serum levels are associated with endothelial progenitor cells imbalance and disease features in rheumatoid arthritis patients.
title_sort	ifnα serum levels are associated with endothelial progenitor cells imbalance and disease features in rheumatoid arthritis patients.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/8226036b28af416bbae813fb4d1708f4
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IFNα serum levels are associated with endothelial progenitor cells imbalance and disease features in rheumatoid arthritis patients.

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