Abraxas suppresses DNA end resection and limits break-induced replication by controlling SLX4/MUS81 chromatin loading in response to TOP1 inhibitor-induced DNA damage

Break-induced replication (BIR), a subtype of HR, is a mutagenic mechanism that leads to chromosome rearrangements. Here the authors reveal insights into the role of Abraxas in limiting excessive DNA end resection, R-loop accumulation and cells undergoing BIR-dependent mitotic DNA synthesis.

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Autores principales:	Xiao Wu, Bin Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8226c9953c764b84a4d094d2e926a514
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spelling	oai:doaj.org-article:8226c9953c764b84a4d094d2e926a5142021-12-02T17:01:29ZAbraxas suppresses DNA end resection and limits break-induced replication by controlling SLX4/MUS81 chromatin loading in response to TOP1 inhibitor-induced DNA damage10.1038/s41467-021-24665-w2041-1723https://doaj.org/article/8226c9953c764b84a4d094d2e926a5142021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24665-whttps://doaj.org/toc/2041-1723Break-induced replication (BIR), a subtype of HR, is a mutagenic mechanism that leads to chromosome rearrangements. Here the authors reveal insights into the role of Abraxas in limiting excessive DNA end resection, R-loop accumulation and cells undergoing BIR-dependent mitotic DNA synthesis.Xiao WuBin WangNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xiao Wu Bin Wang Abraxas suppresses DNA end resection and limits break-induced replication by controlling SLX4/MUS81 chromatin loading in response to TOP1 inhibitor-induced DNA damage
description	Break-induced replication (BIR), a subtype of HR, is a mutagenic mechanism that leads to chromosome rearrangements. Here the authors reveal insights into the role of Abraxas in limiting excessive DNA end resection, R-loop accumulation and cells undergoing BIR-dependent mitotic DNA synthesis.
format	article
author	Xiao Wu Bin Wang
author_facet	Xiao Wu Bin Wang
author_sort	Xiao Wu
title	Abraxas suppresses DNA end resection and limits break-induced replication by controlling SLX4/MUS81 chromatin loading in response to TOP1 inhibitor-induced DNA damage
title_short	Abraxas suppresses DNA end resection and limits break-induced replication by controlling SLX4/MUS81 chromatin loading in response to TOP1 inhibitor-induced DNA damage
title_full	Abraxas suppresses DNA end resection and limits break-induced replication by controlling SLX4/MUS81 chromatin loading in response to TOP1 inhibitor-induced DNA damage
title_fullStr	Abraxas suppresses DNA end resection and limits break-induced replication by controlling SLX4/MUS81 chromatin loading in response to TOP1 inhibitor-induced DNA damage
title_full_unstemmed	Abraxas suppresses DNA end resection and limits break-induced replication by controlling SLX4/MUS81 chromatin loading in response to TOP1 inhibitor-induced DNA damage
title_sort	abraxas suppresses dna end resection and limits break-induced replication by controlling slx4/mus81 chromatin loading in response to top1 inhibitor-induced dna damage
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/8226c9953c764b84a4d094d2e926a514
work_keys_str_mv	AT xiaowu abraxassuppressesdnaendresectionandlimitsbreakinducedreplicationbycontrollingslx4mus81chromatinloadinginresponsetotop1inhibitorinduceddnadamage AT binwang abraxassuppressesdnaendresectionandlimitsbreakinducedreplicationbycontrollingslx4mus81chromatinloadinginresponsetotop1inhibitorinduceddnadamage
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Abraxas suppresses DNA end resection and limits break-induced replication by controlling SLX4/MUS81 chromatin loading in response to TOP1 inhibitor-induced DNA damage

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