Ketamine disinhibits dendrites and enhances calcium signals in prefrontal dendritic spines

The authors show that a subanesthetic dose of ketamine markedly elevate calcium signals in apical dendritic spines in the mouse prefrontal cortex. This effect is driven by a local-circuit mechanism that involves the suppression of somatostatin interneurons leading to dendritic disinhibition.

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Autores principales:	Farhan Ali, Danielle M. Gerhard, Katherine Sweasy, Santosh Pothula, Christopher Pittenger, Ronald S. Duman, Alex C. Kwan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8227533bb0654c70a5cd7563059e67a7
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spelling	oai:doaj.org-article:8227533bb0654c70a5cd7563059e67a72021-12-02T14:40:28ZKetamine disinhibits dendrites and enhances calcium signals in prefrontal dendritic spines10.1038/s41467-019-13809-82041-1723https://doaj.org/article/8227533bb0654c70a5cd7563059e67a72020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13809-8https://doaj.org/toc/2041-1723The authors show that a subanesthetic dose of ketamine markedly elevate calcium signals in apical dendritic spines in the mouse prefrontal cortex. This effect is driven by a local-circuit mechanism that involves the suppression of somatostatin interneurons leading to dendritic disinhibition.Farhan AliDanielle M. GerhardKatherine SweasySantosh PothulaChristopher PittengerRonald S. DumanAlex C. KwanNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Farhan Ali Danielle M. Gerhard Katherine Sweasy Santosh Pothula Christopher Pittenger Ronald S. Duman Alex C. Kwan Ketamine disinhibits dendrites and enhances calcium signals in prefrontal dendritic spines
description	The authors show that a subanesthetic dose of ketamine markedly elevate calcium signals in apical dendritic spines in the mouse prefrontal cortex. This effect is driven by a local-circuit mechanism that involves the suppression of somatostatin interneurons leading to dendritic disinhibition.
format	article
author	Farhan Ali Danielle M. Gerhard Katherine Sweasy Santosh Pothula Christopher Pittenger Ronald S. Duman Alex C. Kwan
author_facet	Farhan Ali Danielle M. Gerhard Katherine Sweasy Santosh Pothula Christopher Pittenger Ronald S. Duman Alex C. Kwan
author_sort	Farhan Ali
title	Ketamine disinhibits dendrites and enhances calcium signals in prefrontal dendritic spines
title_short	Ketamine disinhibits dendrites and enhances calcium signals in prefrontal dendritic spines
title_full	Ketamine disinhibits dendrites and enhances calcium signals in prefrontal dendritic spines
title_fullStr	Ketamine disinhibits dendrites and enhances calcium signals in prefrontal dendritic spines
title_full_unstemmed	Ketamine disinhibits dendrites and enhances calcium signals in prefrontal dendritic spines
title_sort	ketamine disinhibits dendrites and enhances calcium signals in prefrontal dendritic spines
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/8227533bb0654c70a5cd7563059e67a7
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Ketamine disinhibits dendrites and enhances calcium signals in prefrontal dendritic spines

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