MMAB promotes negative feedback control of cholesterol homeostasis

The mechanisms governing cholesterol homeostasis remain incompletely understood. Here, the authors develop an integrative genomic strategy to identify MMAB, and enzyme in the adenosylcobalamin pathway, as a regulator of hepatic LDLR activity and cholesterol biosynthesis.

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Detalles Bibliográficos
Autores principales:	Leigh Goedeke, Alberto Canfrán-Duque, Noemi Rotllan, Balkrishna Chaube, Bonne M. Thompson, Richard G. Lee, Gary W. Cline, Jeffrey G. McDonald, Gerald I. Shulman, Miguel A. Lasunción, Yajaira Suárez, Carlos Fernández-Hernando
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/822cd3ae48234a3c882c3e30c74ffa1c
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spelling	oai:doaj.org-article:822cd3ae48234a3c882c3e30c74ffa1c2021-11-14T12:35:12ZMMAB promotes negative feedback control of cholesterol homeostasis10.1038/s41467-021-26787-72041-1723https://doaj.org/article/822cd3ae48234a3c882c3e30c74ffa1c2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26787-7https://doaj.org/toc/2041-1723The mechanisms governing cholesterol homeostasis remain incompletely understood. Here, the authors develop an integrative genomic strategy to identify MMAB, and enzyme in the adenosylcobalamin pathway, as a regulator of hepatic LDLR activity and cholesterol biosynthesis.Leigh GoedekeAlberto Canfrán-DuqueNoemi RotllanBalkrishna ChaubeBonne M. ThompsonRichard G. LeeGary W. ClineJeffrey G. McDonaldGerald I. ShulmanMiguel A. LasunciónYajaira SuárezCarlos Fernández-HernandoNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Leigh Goedeke Alberto Canfrán-Duque Noemi Rotllan Balkrishna Chaube Bonne M. Thompson Richard G. Lee Gary W. Cline Jeffrey G. McDonald Gerald I. Shulman Miguel A. Lasunción Yajaira Suárez Carlos Fernández-Hernando MMAB promotes negative feedback control of cholesterol homeostasis
description	The mechanisms governing cholesterol homeostasis remain incompletely understood. Here, the authors develop an integrative genomic strategy to identify MMAB, and enzyme in the adenosylcobalamin pathway, as a regulator of hepatic LDLR activity and cholesterol biosynthesis.
format	article
author	Leigh Goedeke Alberto Canfrán-Duque Noemi Rotllan Balkrishna Chaube Bonne M. Thompson Richard G. Lee Gary W. Cline Jeffrey G. McDonald Gerald I. Shulman Miguel A. Lasunción Yajaira Suárez Carlos Fernández-Hernando
author_facet	Leigh Goedeke Alberto Canfrán-Duque Noemi Rotllan Balkrishna Chaube Bonne M. Thompson Richard G. Lee Gary W. Cline Jeffrey G. McDonald Gerald I. Shulman Miguel A. Lasunción Yajaira Suárez Carlos Fernández-Hernando
author_sort	Leigh Goedeke
title	MMAB promotes negative feedback control of cholesterol homeostasis
title_short	MMAB promotes negative feedback control of cholesterol homeostasis
title_full	MMAB promotes negative feedback control of cholesterol homeostasis
title_fullStr	MMAB promotes negative feedback control of cholesterol homeostasis
title_full_unstemmed	MMAB promotes negative feedback control of cholesterol homeostasis
title_sort	mmab promotes negative feedback control of cholesterol homeostasis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/822cd3ae48234a3c882c3e30c74ffa1c
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_version_	1718429116338798592

MMAB promotes negative feedback control of cholesterol homeostasis

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