Differential TGFβ pathway targeting by miR-122 in humans and mice affects liver cancer metastasis

Differential TGFβ pathway targeting by miR-122 in humans and mice affects liver cancer metastasis

MiR-122 levels correlate with metastasis in human liver cancer but not in mouse models. Here the authors show that miR-122 targets TGFßR1 in mice but TGFß1 in humans, that swapping this specificity affects metastasis, and that many other receptor-ligand pairs are differentially targeted by miRNAs ac...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Shenyi Yin, Yu Fan, Hanshuo Zhang, Zhihua Zhao, Yang Hao, Juan Li, Changhong Sun, Junyu Yang, Zhenjun Yang, Xiao Yang, Jian Lu, Jianzhong Jeff Xi
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/8232418e5d184dbe8c6dea083f486f28
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:8232418e5d184dbe8c6dea083f486f28
record_format dspace
spelling oai:doaj.org-article:8232418e5d184dbe8c6dea083f486f282021-12-02T17:32:54ZDifferential TGFβ pathway targeting by miR-122 in humans and mice affects liver cancer metastasis10.1038/ncomms110122041-1723https://doaj.org/article/8232418e5d184dbe8c6dea083f486f282016-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms11012https://doaj.org/toc/2041-1723MiR-122 levels correlate with metastasis in human liver cancer but not in mouse models. Here the authors show that miR-122 targets TGFßR1 in mice but TGFß1 in humans, that swapping this specificity affects metastasis, and that many other receptor-ligand pairs are differentially targeted by miRNAs across species.Shenyi YinYu FanHanshuo ZhangZhihua ZhaoYang HaoJuan LiChanghong SunJunyu YangZhenjun YangXiao YangJian LuJianzhong Jeff XiNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Shenyi Yin
Yu Fan
Hanshuo Zhang
Zhihua Zhao
Yang Hao
Juan Li
Changhong Sun
Junyu Yang
Zhenjun Yang
Xiao Yang
Jian Lu
Jianzhong Jeff Xi
Differential TGFβ pathway targeting by miR-122 in humans and mice affects liver cancer metastasis
description MiR-122 levels correlate with metastasis in human liver cancer but not in mouse models. Here the authors show that miR-122 targets TGFßR1 in mice but TGFß1 in humans, that swapping this specificity affects metastasis, and that many other receptor-ligand pairs are differentially targeted by miRNAs across species.
format article
author Shenyi Yin
Yu Fan
Hanshuo Zhang
Zhihua Zhao
Yang Hao
Juan Li
Changhong Sun
Junyu Yang
Zhenjun Yang
Xiao Yang
Jian Lu
Jianzhong Jeff Xi
author_facet Shenyi Yin
Yu Fan
Hanshuo Zhang
Zhihua Zhao
Yang Hao
Juan Li
Changhong Sun
Junyu Yang
Zhenjun Yang
Xiao Yang
Jian Lu
Jianzhong Jeff Xi
author_sort Shenyi Yin
title Differential TGFβ pathway targeting by miR-122 in humans and mice affects liver cancer metastasis
title_short Differential TGFβ pathway targeting by miR-122 in humans and mice affects liver cancer metastasis
title_full Differential TGFβ pathway targeting by miR-122 in humans and mice affects liver cancer metastasis
title_fullStr Differential TGFβ pathway targeting by miR-122 in humans and mice affects liver cancer metastasis
title_full_unstemmed Differential TGFβ pathway targeting by miR-122 in humans and mice affects liver cancer metastasis
title_sort differential tgfβ pathway targeting by mir-122 in humans and mice affects liver cancer metastasis
publisher Nature Portfolio
publishDate 2016
url https://doaj.org/article/8232418e5d184dbe8c6dea083f486f28
work_keys_str_mv AT shenyiyin differentialtgfbpathwaytargetingbymir122inhumansandmiceaffectslivercancermetastasis
AT yufan differentialtgfbpathwaytargetingbymir122inhumansandmiceaffectslivercancermetastasis
AT hanshuozhang differentialtgfbpathwaytargetingbymir122inhumansandmiceaffectslivercancermetastasis
AT zhihuazhao differentialtgfbpathwaytargetingbymir122inhumansandmiceaffectslivercancermetastasis
AT yanghao differentialtgfbpathwaytargetingbymir122inhumansandmiceaffectslivercancermetastasis
AT juanli differentialtgfbpathwaytargetingbymir122inhumansandmiceaffectslivercancermetastasis
AT changhongsun differentialtgfbpathwaytargetingbymir122inhumansandmiceaffectslivercancermetastasis
AT junyuyang differentialtgfbpathwaytargetingbymir122inhumansandmiceaffectslivercancermetastasis
AT zhenjunyang differentialtgfbpathwaytargetingbymir122inhumansandmiceaffectslivercancermetastasis
AT xiaoyang differentialtgfbpathwaytargetingbymir122inhumansandmiceaffectslivercancermetastasis
AT jianlu differentialtgfbpathwaytargetingbymir122inhumansandmiceaffectslivercancermetastasis
AT jianzhongjeffxi differentialtgfbpathwaytargetingbymir122inhumansandmiceaffectslivercancermetastasis
_version_ 1718380131816308736

Ejemplares similares