Structure-based design of chimeric antigens for multivalent protein vaccines

Factor H binding protein (fHbp) and PorA are components of experimental serogroup B N. meningitidis vaccines. Here the authors graft the VR2 loop of PorA onto an fHBp-based scaffold to demonstrate proof-of-principle of a chimeric antigen strategy and vaccination against meningococcal disease.

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Autores principales:	S. Hollingshead, I. Jongerius, R. M. Exley, S. Johnson, S. M. Lea, C. M. Tang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/823538b9d7624657ba20526bd2a41c1a
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spelling	oai:doaj.org-article:823538b9d7624657ba20526bd2a41c1a2021-12-02T15:34:46ZStructure-based design of chimeric antigens for multivalent protein vaccines10.1038/s41467-018-03146-72041-1723https://doaj.org/article/823538b9d7624657ba20526bd2a41c1a2018-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03146-7https://doaj.org/toc/2041-1723Factor H binding protein (fHbp) and PorA are components of experimental serogroup B N. meningitidis vaccines. Here the authors graft the VR2 loop of PorA onto an fHBp-based scaffold to demonstrate proof-of-principle of a chimeric antigen strategy and vaccination against meningococcal disease.S. HollingsheadI. JongeriusR. M. ExleyS. JohnsonS. M. LeaC. M. TangNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q S. Hollingshead I. Jongerius R. M. Exley S. Johnson S. M. Lea C. M. Tang Structure-based design of chimeric antigens for multivalent protein vaccines
description	Factor H binding protein (fHbp) and PorA are components of experimental serogroup B N. meningitidis vaccines. Here the authors graft the VR2 loop of PorA onto an fHBp-based scaffold to demonstrate proof-of-principle of a chimeric antigen strategy and vaccination against meningococcal disease.
format	article
author	S. Hollingshead I. Jongerius R. M. Exley S. Johnson S. M. Lea C. M. Tang
author_facet	S. Hollingshead I. Jongerius R. M. Exley S. Johnson S. M. Lea C. M. Tang
author_sort	S. Hollingshead
title	Structure-based design of chimeric antigens for multivalent protein vaccines
title_short	Structure-based design of chimeric antigens for multivalent protein vaccines
title_full	Structure-based design of chimeric antigens for multivalent protein vaccines
title_fullStr	Structure-based design of chimeric antigens for multivalent protein vaccines
title_full_unstemmed	Structure-based design of chimeric antigens for multivalent protein vaccines
title_sort	structure-based design of chimeric antigens for multivalent protein vaccines
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/823538b9d7624657ba20526bd2a41c1a
work_keys_str_mv	AT shollingshead structurebaseddesignofchimericantigensformultivalentproteinvaccines AT ijongerius structurebaseddesignofchimericantigensformultivalentproteinvaccines AT rmexley structurebaseddesignofchimericantigensformultivalentproteinvaccines AT sjohnson structurebaseddesignofchimericantigensformultivalentproteinvaccines AT smlea structurebaseddesignofchimericantigensformultivalentproteinvaccines AT cmtang structurebaseddesignofchimericantigensformultivalentproteinvaccines
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Structure-based design of chimeric antigens for multivalent protein vaccines

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