LAMTOR2-mediated modulation of NGF/MAPK activation kinetics during differentiation of PC12 cells.

LAMTOR2-mediated modulation of NGF/MAPK activation kinetics during differentiation of PC12 cells.

LAMTOR2 (p14), a part of the larger LAMTOR/Ragulator complex, plays a crucial role in EGF-dependent activation of p42/44 mitogen-activated protein kinases (MAPK, ERK1/2). In this study, we investigated the role of LAMTOR2 in nerve growth factor (NGF)-mediated neuronal differentiation. Stimulation of...

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Autores principales: Bettina Thauerer, Paul Voegele, Natascha Hermann-Kleiter, Nikolaus Thuille, Mariana E G de Araujo, Martin Offterdinger, Gottfried Baier, Lukas A Huber, Gabriele Baier-Bitterlich
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2014
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/8237df9269a84107abcf61288544676a
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