An ambivalent prostate nodule after Bacillus Calmette-Guérin therapy

A 65-year-old patient without specific associated pathology was treated for a high-grade non-invasive papillary urothelial carcinoma by surgery associated with repeated intravesical Bacillus Calmette-Guérin (BCG) instillations. During follow-up, magnetic resonance imaging (MRI) found a clinically in...

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Autores principales:	L. Sauvat, Q. Lhermite, C. Desplechain, B. Long, M. Vidal
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Prostatitis Prostate cancer Tuberculosis BCG treatment Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/8238418c01454fb295f64f071e8d13d8
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spelling	oai:doaj.org-article:8238418c01454fb295f64f071e8d13d82021-11-22T04:25:22ZAn ambivalent prostate nodule after Bacillus Calmette-Guérin therapy2214-250910.1016/j.idcr.2021.e01338https://doaj.org/article/8238418c01454fb295f64f071e8d13d82021-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2214250921002948https://doaj.org/toc/2214-2509A 65-year-old patient without specific associated pathology was treated for a high-grade non-invasive papillary urothelial carcinoma by surgery associated with repeated intravesical Bacillus Calmette-Guérin (BCG) instillations. During follow-up, magnetic resonance imaging (MRI) found a clinically indurated prostate nodule with suspected extensive capsular invasion. Prostatic biopsies showed epithelioid and giant-cell granuloma associated with a single focus of adenocarcinoma. Urinary culture test and specific PCR confirmed the involvement of Mycobacterium bovis. The patient was treated first by rifampin, isoniazid and ethambutol and then by rifampin and isoniazid for a total duration of 9 months, with MRI reassessment at various intervals. After BCG therapy, systemic infectious complications but also local complications such as granulomatous disease have been reported, but prostatic abscesses with M. bovis mimicking cancer on MRI are rare. Consequently, we advise specific local urinary and prostate samples to test for mycobacteria (staining, culture, PCR) in order to avoid aggressive high-risk prostatic surgery.L. SauvatQ. LhermiteC. DesplechainB. LongM. VidalElsevierarticleProstatitisProstate cancerTuberculosisBCG treatmentInfectious and parasitic diseasesRC109-216ENIDCases, Vol 26, Iss , Pp e01338- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Prostatitis Prostate cancer Tuberculosis BCG treatment Infectious and parasitic diseases RC109-216
spellingShingle	Prostatitis Prostate cancer Tuberculosis BCG treatment Infectious and parasitic diseases RC109-216 L. Sauvat Q. Lhermite C. Desplechain B. Long M. Vidal An ambivalent prostate nodule after Bacillus Calmette-Guérin therapy
description	A 65-year-old patient without specific associated pathology was treated for a high-grade non-invasive papillary urothelial carcinoma by surgery associated with repeated intravesical Bacillus Calmette-Guérin (BCG) instillations. During follow-up, magnetic resonance imaging (MRI) found a clinically indurated prostate nodule with suspected extensive capsular invasion. Prostatic biopsies showed epithelioid and giant-cell granuloma associated with a single focus of adenocarcinoma. Urinary culture test and specific PCR confirmed the involvement of Mycobacterium bovis. The patient was treated first by rifampin, isoniazid and ethambutol and then by rifampin and isoniazid for a total duration of 9 months, with MRI reassessment at various intervals. After BCG therapy, systemic infectious complications but also local complications such as granulomatous disease have been reported, but prostatic abscesses with M. bovis mimicking cancer on MRI are rare. Consequently, we advise specific local urinary and prostate samples to test for mycobacteria (staining, culture, PCR) in order to avoid aggressive high-risk prostatic surgery.
format	article
author	L. Sauvat Q. Lhermite C. Desplechain B. Long M. Vidal
author_facet	L. Sauvat Q. Lhermite C. Desplechain B. Long M. Vidal
author_sort	L. Sauvat
title	An ambivalent prostate nodule after Bacillus Calmette-Guérin therapy
title_short	An ambivalent prostate nodule after Bacillus Calmette-Guérin therapy
title_full	An ambivalent prostate nodule after Bacillus Calmette-Guérin therapy
title_fullStr	An ambivalent prostate nodule after Bacillus Calmette-Guérin therapy
title_full_unstemmed	An ambivalent prostate nodule after Bacillus Calmette-Guérin therapy
title_sort	ambivalent prostate nodule after bacillus calmette-guérin therapy
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/8238418c01454fb295f64f071e8d13d8
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An ambivalent prostate nodule after Bacillus Calmette-Guérin therapy

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