Persistent exposure to Mycoplasma induces malignant transformation of human prostate cells.

Recent epidemiologic, genetic, and molecular studies suggest infection and inflammation initiate certain cancers, including those of the prostate. The American Cancer Society, estimates that approximately 20% of all worldwide cancers are caused by infection. Mycoplasma, a genus of bacteria that lack...

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Autores principales:	Kazunori Namiki, Steve Goodison, Stacy Porvasnik, Robert W Allan, Kenneth A Iczkowski, Cydney Urbanek, Leticia Reyes, Noboru Sakamoto, Charles J Rosser
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2009
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8238ac4bb1364592af35284076a8a70e
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spelling	oai:doaj.org-article:8238ac4bb1364592af35284076a8a70e2021-11-25T06:20:38ZPersistent exposure to Mycoplasma induces malignant transformation of human prostate cells.1932-620310.1371/journal.pone.0006872https://doaj.org/article/8238ac4bb1364592af35284076a8a70e2009-09-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19721714/?tool=EBIhttps://doaj.org/toc/1932-6203Recent epidemiologic, genetic, and molecular studies suggest infection and inflammation initiate certain cancers, including those of the prostate. The American Cancer Society, estimates that approximately 20% of all worldwide cancers are caused by infection. Mycoplasma, a genus of bacteria that lack a cell wall, are among the few prokaryotes that can grow in close relationship with mammalian cells, often without any apparent pathology, for extended periods of time. In this study, the capacity of Mycoplasma genitalium, a prevalent sexually transmitted infection, and Mycoplasma hyorhinis, a mycoplasma found at unusually high frequency among patients with AIDS, to induce a malignant phenotype in benign human prostate cells (BPH-1) was evaluated using a series of in vitro and in vivo assays. After 19 weeks of culture, infected BPH-1 cells achieved anchorage-independent growth and increased migration and invasion. Malignant transformation of infected BPH-1 cells was confirmed by the formation of xenograft tumors in athymic mice. Associated with these changes was an increase in karyotypic entropy, evident by the accumulation of chromosomal aberrations and polysomy. This is the first report describing the capacity of M. genitalium or M. hyorhinis infection to lead to the malignant transformation of benign human epithelial cells and may serve as a model to further study the relationship between prostatitis and prostatic carcinogenesis.Kazunori NamikiSteve GoodisonStacy PorvasnikRobert W AllanKenneth A IczkowskiCydney UrbanekLeticia ReyesNoboru SakamotoCharles J RosserPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 4, Iss 9, p e6872 (2009)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kazunori Namiki Steve Goodison Stacy Porvasnik Robert W Allan Kenneth A Iczkowski Cydney Urbanek Leticia Reyes Noboru Sakamoto Charles J Rosser Persistent exposure to Mycoplasma induces malignant transformation of human prostate cells.
description	Recent epidemiologic, genetic, and molecular studies suggest infection and inflammation initiate certain cancers, including those of the prostate. The American Cancer Society, estimates that approximately 20% of all worldwide cancers are caused by infection. Mycoplasma, a genus of bacteria that lack a cell wall, are among the few prokaryotes that can grow in close relationship with mammalian cells, often without any apparent pathology, for extended periods of time. In this study, the capacity of Mycoplasma genitalium, a prevalent sexually transmitted infection, and Mycoplasma hyorhinis, a mycoplasma found at unusually high frequency among patients with AIDS, to induce a malignant phenotype in benign human prostate cells (BPH-1) was evaluated using a series of in vitro and in vivo assays. After 19 weeks of culture, infected BPH-1 cells achieved anchorage-independent growth and increased migration and invasion. Malignant transformation of infected BPH-1 cells was confirmed by the formation of xenograft tumors in athymic mice. Associated with these changes was an increase in karyotypic entropy, evident by the accumulation of chromosomal aberrations and polysomy. This is the first report describing the capacity of M. genitalium or M. hyorhinis infection to lead to the malignant transformation of benign human epithelial cells and may serve as a model to further study the relationship between prostatitis and prostatic carcinogenesis.
format	article
author	Kazunori Namiki Steve Goodison Stacy Porvasnik Robert W Allan Kenneth A Iczkowski Cydney Urbanek Leticia Reyes Noboru Sakamoto Charles J Rosser
author_facet	Kazunori Namiki Steve Goodison Stacy Porvasnik Robert W Allan Kenneth A Iczkowski Cydney Urbanek Leticia Reyes Noboru Sakamoto Charles J Rosser
author_sort	Kazunori Namiki
title	Persistent exposure to Mycoplasma induces malignant transformation of human prostate cells.
title_short	Persistent exposure to Mycoplasma induces malignant transformation of human prostate cells.
title_full	Persistent exposure to Mycoplasma induces malignant transformation of human prostate cells.
title_fullStr	Persistent exposure to Mycoplasma induces malignant transformation of human prostate cells.
title_full_unstemmed	Persistent exposure to Mycoplasma induces malignant transformation of human prostate cells.
title_sort	persistent exposure to mycoplasma induces malignant transformation of human prostate cells.
publisher	Public Library of Science (PLoS)
publishDate	2009
url	https://doaj.org/article/8238ac4bb1364592af35284076a8a70e
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Persistent exposure to Mycoplasma induces malignant transformation of human prostate cells.

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