Treatment with mRNA coding for the necroptosis mediator MLKL induces antitumor immunity directed against neo-epitopes

Necroptosis has immunogenic cell death properties. Here, the authors show that the intra-tumor delivery of mRNA that codes for the necroptosis effector MLKL triggers neo-epitope-specific anti-tumor T cell responses and inhibits primary tumor growth and lung metastasis.

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Detalles Bibliográficos
Autores principales:	Lien Van Hoecke, Sandra Van Lint, Kenny Roose, Alexander Van Parys, Peter Vandenabeele, Johan Grooten, Jan Tavernier, Stefaan De Koker, Xavier Saelens
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8238d6be45a64c8a92375d54457b3e83
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spelling	oai:doaj.org-article:8238d6be45a64c8a92375d54457b3e832021-12-02T15:34:05ZTreatment with mRNA coding for the necroptosis mediator MLKL induces antitumor immunity directed against neo-epitopes10.1038/s41467-018-05979-82041-1723https://doaj.org/article/8238d6be45a64c8a92375d54457b3e832018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05979-8https://doaj.org/toc/2041-1723Necroptosis has immunogenic cell death properties. Here, the authors show that the intra-tumor delivery of mRNA that codes for the necroptosis effector MLKL triggers neo-epitope-specific anti-tumor T cell responses and inhibits primary tumor growth and lung metastasis.Lien Van HoeckeSandra Van LintKenny RooseAlexander Van ParysPeter VandenabeeleJohan GrootenJan TavernierStefaan De KokerXavier SaelensNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lien Van Hoecke Sandra Van Lint Kenny Roose Alexander Van Parys Peter Vandenabeele Johan Grooten Jan Tavernier Stefaan De Koker Xavier Saelens Treatment with mRNA coding for the necroptosis mediator MLKL induces antitumor immunity directed against neo-epitopes
description	Necroptosis has immunogenic cell death properties. Here, the authors show that the intra-tumor delivery of mRNA that codes for the necroptosis effector MLKL triggers neo-epitope-specific anti-tumor T cell responses and inhibits primary tumor growth and lung metastasis.
format	article
author	Lien Van Hoecke Sandra Van Lint Kenny Roose Alexander Van Parys Peter Vandenabeele Johan Grooten Jan Tavernier Stefaan De Koker Xavier Saelens
author_facet	Lien Van Hoecke Sandra Van Lint Kenny Roose Alexander Van Parys Peter Vandenabeele Johan Grooten Jan Tavernier Stefaan De Koker Xavier Saelens
author_sort	Lien Van Hoecke
title	Treatment with mRNA coding for the necroptosis mediator MLKL induces antitumor immunity directed against neo-epitopes
title_short	Treatment with mRNA coding for the necroptosis mediator MLKL induces antitumor immunity directed against neo-epitopes
title_full	Treatment with mRNA coding for the necroptosis mediator MLKL induces antitumor immunity directed against neo-epitopes
title_fullStr	Treatment with mRNA coding for the necroptosis mediator MLKL induces antitumor immunity directed against neo-epitopes
title_full_unstemmed	Treatment with mRNA coding for the necroptosis mediator MLKL induces antitumor immunity directed against neo-epitopes
title_sort	treatment with mrna coding for the necroptosis mediator mlkl induces antitumor immunity directed against neo-epitopes
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/8238d6be45a64c8a92375d54457b3e83
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Treatment with mRNA coding for the necroptosis mediator MLKL induces antitumor immunity directed against neo-epitopes

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