Overexpression of Adiponectin Receptors in Opium Users with and without Cancer

Negar Firouzabadi,1– 3 Maral Haghnegahdar,1 Bahman Khalvati,4 Ali Dehshahri,5 Ehsan Bahramali6 1Department of Pharmacology & Toxicology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran; 2Pharmaceutical Sciences Research Center, Shiraz University of Medical S...

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Autores principales:	Firouzabadi N, Haghnegahdar M, Khalvati B, Dehshahri A, Bahramali E
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	opium addiction adiponectin adiponectin receptors cancer Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/8239ba896cad4bad917490013c7fa5b4
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spelling	oai:doaj.org-article:8239ba896cad4bad917490013c7fa5b42021-12-02T11:10:47ZOverexpression of Adiponectin Receptors in Opium Users with and without Cancer1179-1438https://doaj.org/article/8239ba896cad4bad917490013c7fa5b42020-06-01T00:00:00Zhttps://www.dovepress.com/overexpression-of-adiponectin-receptors-in-opium-users-with-and-withou-peer-reviewed-article-CPAAhttps://doaj.org/toc/1179-1438Negar Firouzabadi,1– 3 Maral Haghnegahdar,1 Bahman Khalvati,4 Ali Dehshahri,5 Ehsan Bahramali6 1Department of Pharmacology & Toxicology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran; 2Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran; 3Non-Communicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran; 4Medicinal Plants Research Center, Yasuj University of Medical Sciences, Yasuj, Iran; 5Department of Pharmaceutical Biotechnology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran; 6Digestive Disease Research Center, Digestive Disease Research Institute, Shariati Hospital, Tehran University of Medical Sciences, Tehran, IranCorrespondence: Negar FirouzabadiDepartment of Pharmacology & Toxicology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, IranTel +98-917-314-5303Fax +98-713-2424128Email nfirouzabadi@yahoo.comAim: Opium addiction is a serious public health concern in the Middle East countries causing various illnesses. Opium use is associated with an increased risk of several cancers; however, the underlying mechanisms are not yet fully elucidated. Altered levels of adiponectin and its related main receptors, Adiponectin receptor 1 and 2 (AdipoR1 and AdipoR2) have been associated with several malignancies. Opium users are at risk of various cancers. All together let us to the hypothesis that probable overexpression of AdipoRs in opium users might be linked to the occurrence of cancer in this population.Methods: One hundred opium users along with 100 healthy non-opium users were enrolled in the study. Opium users were followed up for 5 years (2014– 2019) to evaluate the occurrence of malignancies. AdipoR1 and AdipoR2 expressions were measured using a flow cytometry method.Results: Expression of AdipoR1 and AdipoR2 was significantly higher in opium users compared with the healthy control group (P=0.0001 and 0.0001, respectively). Eight opium users developed cancer during the follow-up period. Subjects abusing opium developed cancer by 8.6 folds comparing to non-opium users (P=0.034; OR=8.6; 95% CI (1.06– 70.1)). Expression of these two receptors was significantly higher in opium users developing cancer compared with cancer-free opium (P=0.001).Conclusion: Considering the significant overexpression of AdipoR1 and AdipoR2 in opium users and in opium users who developed malignancies and the association between upregulation of these receptors in most cancers affecting opium users and assessment of AdipoRs may serve as an early detection tool of cancer in this population.Keywords: opium, addiction, adiponectin, adiponectin receptors, cancerFirouzabadi NHaghnegahdar MKhalvati BDehshahri ABahramali EDove Medical Pressarticleopiumaddictionadiponectinadiponectin receptorscancerTherapeutics. PharmacologyRM1-950ENClinical Pharmacology: Advances and Applications, Vol Volume 12, Pp 59-65 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	opium addiction adiponectin adiponectin receptors cancer Therapeutics. Pharmacology RM1-950
spellingShingle	opium addiction adiponectin adiponectin receptors cancer Therapeutics. Pharmacology RM1-950 Firouzabadi N Haghnegahdar M Khalvati B Dehshahri A Bahramali E Overexpression of Adiponectin Receptors in Opium Users with and without Cancer
description	Negar Firouzabadi,1– 3 Maral Haghnegahdar,1 Bahman Khalvati,4 Ali Dehshahri,5 Ehsan Bahramali6 1Department of Pharmacology & Toxicology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran; 2Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran; 3Non-Communicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran; 4Medicinal Plants Research Center, Yasuj University of Medical Sciences, Yasuj, Iran; 5Department of Pharmaceutical Biotechnology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran; 6Digestive Disease Research Center, Digestive Disease Research Institute, Shariati Hospital, Tehran University of Medical Sciences, Tehran, IranCorrespondence: Negar FirouzabadiDepartment of Pharmacology & Toxicology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, IranTel +98-917-314-5303Fax +98-713-2424128Email nfirouzabadi@yahoo.comAim: Opium addiction is a serious public health concern in the Middle East countries causing various illnesses. Opium use is associated with an increased risk of several cancers; however, the underlying mechanisms are not yet fully elucidated. Altered levels of adiponectin and its related main receptors, Adiponectin receptor 1 and 2 (AdipoR1 and AdipoR2) have been associated with several malignancies. Opium users are at risk of various cancers. All together let us to the hypothesis that probable overexpression of AdipoRs in opium users might be linked to the occurrence of cancer in this population.Methods: One hundred opium users along with 100 healthy non-opium users were enrolled in the study. Opium users were followed up for 5 years (2014– 2019) to evaluate the occurrence of malignancies. AdipoR1 and AdipoR2 expressions were measured using a flow cytometry method.Results: Expression of AdipoR1 and AdipoR2 was significantly higher in opium users compared with the healthy control group (P=0.0001 and 0.0001, respectively). Eight opium users developed cancer during the follow-up period. Subjects abusing opium developed cancer by 8.6 folds comparing to non-opium users (P=0.034; OR=8.6; 95% CI (1.06– 70.1)). Expression of these two receptors was significantly higher in opium users developing cancer compared with cancer-free opium (P=0.001).Conclusion: Considering the significant overexpression of AdipoR1 and AdipoR2 in opium users and in opium users who developed malignancies and the association between upregulation of these receptors in most cancers affecting opium users and assessment of AdipoRs may serve as an early detection tool of cancer in this population.Keywords: opium, addiction, adiponectin, adiponectin receptors, cancer
format	article
author	Firouzabadi N Haghnegahdar M Khalvati B Dehshahri A Bahramali E
author_facet	Firouzabadi N Haghnegahdar M Khalvati B Dehshahri A Bahramali E
author_sort	Firouzabadi N
title	Overexpression of Adiponectin Receptors in Opium Users with and without Cancer
title_short	Overexpression of Adiponectin Receptors in Opium Users with and without Cancer
title_full	Overexpression of Adiponectin Receptors in Opium Users with and without Cancer
title_fullStr	Overexpression of Adiponectin Receptors in Opium Users with and without Cancer
title_full_unstemmed	Overexpression of Adiponectin Receptors in Opium Users with and without Cancer
title_sort	overexpression of adiponectin receptors in opium users with and without cancer
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/8239ba896cad4bad917490013c7fa5b4
work_keys_str_mv	AT firouzabadin overexpressionofadiponectinreceptorsinopiumuserswithandwithoutcancer AT haghnegahdarm overexpressionofadiponectinreceptorsinopiumuserswithandwithoutcancer AT khalvatib overexpressionofadiponectinreceptorsinopiumuserswithandwithoutcancer AT dehshahria overexpressionofadiponectinreceptorsinopiumuserswithandwithoutcancer AT bahramalie overexpressionofadiponectinreceptorsinopiumuserswithandwithoutcancer
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Overexpression of Adiponectin Receptors in Opium Users with and without Cancer

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