Case Report: Newborns With Pseudohypoaldosteronism Secondary to Excessive Gastrointestinal Losses Through High Output Stoma

Life-threatening electrolyte imbalance is not uncommon in preemies. Differential diagnosis is important for immediate treatment. The syndrome of pseudohypoaldosteronism (PHA) is characterized by increased aldosterone secretion associated with clinical signs of hypoaldosteronism reflecting mineraloco...

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Autores principales:	Chia-Yu Ou, Yen-Ju Chen, Geng-Bai Lin, Mei-Fan Chen, Shu-Ti Chia
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	high output stoma hyperkalemia hyponatremia metabolic acidosis pseudohypoaldosteronism Pediatrics RJ1-570
Acceso en línea:	https://doaj.org/article/823a3586587a4256954ac503f8d2a6ec
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spelling	oai:doaj.org-article:823a3586587a4256954ac503f8d2a6ec2021-11-17T06:01:48ZCase Report: Newborns With Pseudohypoaldosteronism Secondary to Excessive Gastrointestinal Losses Through High Output Stoma2296-236010.3389/fped.2021.773246https://doaj.org/article/823a3586587a4256954ac503f8d2a6ec2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fped.2021.773246/fullhttps://doaj.org/toc/2296-2360Life-threatening electrolyte imbalance is not uncommon in preemies. Differential diagnosis is important for immediate treatment. The syndrome of pseudohypoaldosteronism (PHA) is characterized by increased aldosterone secretion associated with clinical signs of hypoaldosteronism reflecting mineralocorticoid resistance. There are type I, type II, and secondary type of PHA. Most secondary PHA reported in the pediatric population result from urinary infection and obstructive uropathy and extremely rarely from gastrointestinal fluid loss. Seven preemies accepted jejunostomy or ileostomy, and they suffered from high output stoma. Electrolyte imbalance with bodyweight loss or cardiac event was noted. We found a high level of aldosterone and renin and diagnosed them with secondary PHA due to excessive gastrointestinal losses. After stomal reversal, aldosterone and renin level became normalized, and electrolyte was corrected. This study reports the finding of secondary pseudohyperaldosteronism (hyponatremia, hyperkalemia, and metabolic acidosis) in a series of cases with intestinal resection and ostomy of different causes. Early stomal reversal was recommended.Chia-Yu OuYen-Ju ChenGeng-Bai LinMei-Fan ChenShu-Ti ChiaShu-Ti ChiaFrontiers Media S.A.articlehigh output stomahyperkalemiahyponatremiametabolic acidosispseudohypoaldosteronismPediatricsRJ1-570ENFrontiers in Pediatrics, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	high output stoma hyperkalemia hyponatremia metabolic acidosis pseudohypoaldosteronism Pediatrics RJ1-570
spellingShingle	high output stoma hyperkalemia hyponatremia metabolic acidosis pseudohypoaldosteronism Pediatrics RJ1-570 Chia-Yu Ou Yen-Ju Chen Geng-Bai Lin Mei-Fan Chen Shu-Ti Chia Shu-Ti Chia Case Report: Newborns With Pseudohypoaldosteronism Secondary to Excessive Gastrointestinal Losses Through High Output Stoma
description	Life-threatening electrolyte imbalance is not uncommon in preemies. Differential diagnosis is important for immediate treatment. The syndrome of pseudohypoaldosteronism (PHA) is characterized by increased aldosterone secretion associated with clinical signs of hypoaldosteronism reflecting mineralocorticoid resistance. There are type I, type II, and secondary type of PHA. Most secondary PHA reported in the pediatric population result from urinary infection and obstructive uropathy and extremely rarely from gastrointestinal fluid loss. Seven preemies accepted jejunostomy or ileostomy, and they suffered from high output stoma. Electrolyte imbalance with bodyweight loss or cardiac event was noted. We found a high level of aldosterone and renin and diagnosed them with secondary PHA due to excessive gastrointestinal losses. After stomal reversal, aldosterone and renin level became normalized, and electrolyte was corrected. This study reports the finding of secondary pseudohyperaldosteronism (hyponatremia, hyperkalemia, and metabolic acidosis) in a series of cases with intestinal resection and ostomy of different causes. Early stomal reversal was recommended.
format	article
author	Chia-Yu Ou Yen-Ju Chen Geng-Bai Lin Mei-Fan Chen Shu-Ti Chia Shu-Ti Chia
author_facet	Chia-Yu Ou Yen-Ju Chen Geng-Bai Lin Mei-Fan Chen Shu-Ti Chia Shu-Ti Chia
author_sort	Chia-Yu Ou
title	Case Report: Newborns With Pseudohypoaldosteronism Secondary to Excessive Gastrointestinal Losses Through High Output Stoma
title_short	Case Report: Newborns With Pseudohypoaldosteronism Secondary to Excessive Gastrointestinal Losses Through High Output Stoma
title_full	Case Report: Newborns With Pseudohypoaldosteronism Secondary to Excessive Gastrointestinal Losses Through High Output Stoma
title_fullStr	Case Report: Newborns With Pseudohypoaldosteronism Secondary to Excessive Gastrointestinal Losses Through High Output Stoma
title_full_unstemmed	Case Report: Newborns With Pseudohypoaldosteronism Secondary to Excessive Gastrointestinal Losses Through High Output Stoma
title_sort	case report: newborns with pseudohypoaldosteronism secondary to excessive gastrointestinal losses through high output stoma
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/823a3586587a4256954ac503f8d2a6ec
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Case Report: Newborns With Pseudohypoaldosteronism Secondary to Excessive Gastrointestinal Losses Through High Output Stoma

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