Application of neurotrophic and proangiogenic factors as therapy after peripheral nervous system injury
The intrinsic ability of peripheral nerves to regenerate after injury is extremely limited, especially in case of severe injury. This often leads to poor motor function and permanent disability. Existing approaches for the treatment of injured nerves do not provide appropriate conditions to support...
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Wolters Kluwer Medknow Publications
2022
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oai:doaj.org-article:823d77f63fbd44699b9b7c6b94f528542021-11-19T12:16:44ZApplication of neurotrophic and proangiogenic factors as therapy after peripheral nervous system injury1673-537410.4103/1673-5374.327329https://doaj.org/article/823d77f63fbd44699b9b7c6b94f528542022-01-01T00:00:00Zhttp://www.nrronline.org/article.asp?issn=1673-5374;year=2022;volume=17;issue=6;spage=1240;epage=1247;aulast=Idrisovahttps://doaj.org/toc/1673-5374The intrinsic ability of peripheral nerves to regenerate after injury is extremely limited, especially in case of severe injury. This often leads to poor motor function and permanent disability. Existing approaches for the treatment of injured nerves do not provide appropriate conditions to support survival and growth of nerve cells. This drawback can be compensated by the use of gene therapy and cell therapy-based drugs that locally provide an increase in the key regulators of nerve growth, including neurotrophic factors and extracellular matrix proteins. Each growth factor plays its own specific angiotrophic or neurotrophic role. Currently, growth factors are widely studied as accelerators of nerve regeneration. Particularly noteworthy is synergy between various growth factors, that is essential for both angiogenesis and neurogenesis. Fibroblast growth factor 2 and vascular endothelial growth factor are widely known for their proangiogenic effects. At the same time, fibroblast growth factor 2 and vascular endothelial growth factor stimulate neural cell growth and play an important role in neurodegenerative diseases of the peripheral nervous system. Taken together, their neurotrophic and angiogenic properties have positive effect on the regeneration process. In this review we provide an in-depth overview of the role of fibroblast growth factor 2 and vascular endothelial growth factor in the regeneration of peripheral nerves, thus demonstrating their neurotherapeutic efficacy in improving neuron survival in the peripheral nervous system.Kamilla Faritovna IdrisovaAlina Kazymovna ZeinalovaGalina Andreevna MasgutovaAlexey Andreevich BogovCinzia AllegrucciValeriia Yurievna SyromiatnikovaIlnur Ildusovich SalafutdinovEkaterna Evgenievna GaraninaDina Ivanovna AndreevaAdilet Abdullaatovich KadyrovAlbert Anatolevich RizvanovRuslan Faridovich MasgutovWolters Kluwer Medknow Publicationsarticlefibroblast growth factor 2; growth factors; nerve growth factor; peripheral nerve injury; peripheral nervous system; vascular endothelial growth factorNeurology. Diseases of the nervous systemRC346-429ENNeural Regeneration Research, Vol 17, Iss 6, Pp 1240-1247 (2022) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
fibroblast growth factor 2; growth factors; nerve growth factor; peripheral nerve injury; peripheral nervous system; vascular endothelial growth factor Neurology. Diseases of the nervous system RC346-429 |
| spellingShingle |
fibroblast growth factor 2; growth factors; nerve growth factor; peripheral nerve injury; peripheral nervous system; vascular endothelial growth factor Neurology. Diseases of the nervous system RC346-429 Kamilla Faritovna Idrisova Alina Kazymovna Zeinalova Galina Andreevna Masgutova Alexey Andreevich Bogov Cinzia Allegrucci Valeriia Yurievna Syromiatnikova Ilnur Ildusovich Salafutdinov Ekaterna Evgenievna Garanina Dina Ivanovna Andreeva Adilet Abdullaatovich Kadyrov Albert Anatolevich Rizvanov Ruslan Faridovich Masgutov Application of neurotrophic and proangiogenic factors as therapy after peripheral nervous system injury |
| description |
The intrinsic ability of peripheral nerves to regenerate after injury is extremely limited, especially in case of severe injury. This often leads to poor motor function and permanent disability. Existing approaches for the treatment of injured nerves do not provide appropriate conditions to support survival and growth of nerve cells. This drawback can be compensated by the use of gene therapy and cell therapy-based drugs that locally provide an increase in the key regulators of nerve growth, including neurotrophic factors and extracellular matrix proteins. Each growth factor plays its own specific angiotrophic or neurotrophic role. Currently, growth factors are widely studied as accelerators of nerve regeneration. Particularly noteworthy is synergy between various growth factors, that is essential for both angiogenesis and neurogenesis. Fibroblast growth factor 2 and vascular endothelial growth factor are widely known for their proangiogenic effects. At the same time, fibroblast growth factor 2 and vascular endothelial growth factor stimulate neural cell growth and play an important role in neurodegenerative diseases of the peripheral nervous system. Taken together, their neurotrophic and angiogenic properties have positive effect on the regeneration process. In this review we provide an in-depth overview of the role of fibroblast growth factor 2 and vascular endothelial growth factor in the regeneration of peripheral nerves, thus demonstrating their neurotherapeutic efficacy in improving neuron survival in the peripheral nervous system. |
| format |
article |
| author |
Kamilla Faritovna Idrisova Alina Kazymovna Zeinalova Galina Andreevna Masgutova Alexey Andreevich Bogov Cinzia Allegrucci Valeriia Yurievna Syromiatnikova Ilnur Ildusovich Salafutdinov Ekaterna Evgenievna Garanina Dina Ivanovna Andreeva Adilet Abdullaatovich Kadyrov Albert Anatolevich Rizvanov Ruslan Faridovich Masgutov |
| author_facet |
Kamilla Faritovna Idrisova Alina Kazymovna Zeinalova Galina Andreevna Masgutova Alexey Andreevich Bogov Cinzia Allegrucci Valeriia Yurievna Syromiatnikova Ilnur Ildusovich Salafutdinov Ekaterna Evgenievna Garanina Dina Ivanovna Andreeva Adilet Abdullaatovich Kadyrov Albert Anatolevich Rizvanov Ruslan Faridovich Masgutov |
| author_sort |
Kamilla Faritovna Idrisova |
| title |
Application of neurotrophic and proangiogenic factors as therapy after peripheral nervous system injury |
| title_short |
Application of neurotrophic and proangiogenic factors as therapy after peripheral nervous system injury |
| title_full |
Application of neurotrophic and proangiogenic factors as therapy after peripheral nervous system injury |
| title_fullStr |
Application of neurotrophic and proangiogenic factors as therapy after peripheral nervous system injury |
| title_full_unstemmed |
Application of neurotrophic and proangiogenic factors as therapy after peripheral nervous system injury |
| title_sort |
application of neurotrophic and proangiogenic factors as therapy after peripheral nervous system injury |
| publisher |
Wolters Kluwer Medknow Publications |
| publishDate |
2022 |
| url |
https://doaj.org/article/823d77f63fbd44699b9b7c6b94f52854 |
| work_keys_str_mv |
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