Formulation and Evaluation of Tablets Compressed from Granules Prepared by Thermoplastic Granulation

The aim of this formulation study was to determine the effect of the binder used in the preparation of granules by thermoplastic granulation on the release of propranolol from experimental tablets. Another aim was to select suitable excipients and their ratio in the granules to ensure a trouble-free...

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Autores principales:	Kľoc D., Wolaschka T., Ruttkay F.
Formato:	article
Lenguaje:	EN
Publicado:	Sciendo 2021
Materias:	thermoplastic granulation propranolol dissolution polyethylene glycol cetyl stearyl alcohol Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/823fe6f29e474180aa45c3735a72f4dc
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spelling	oai:doaj.org-article:823fe6f29e474180aa45c3735a72f4dc2021-12-05T14:11:05ZFormulation and Evaluation of Tablets Compressed from Granules Prepared by Thermoplastic Granulation2453-672510.2478/afpuc-2021-0003https://doaj.org/article/823fe6f29e474180aa45c3735a72f4dc2021-07-01T00:00:00Zhttps://doi.org/10.2478/afpuc-2021-0003https://doaj.org/toc/2453-6725The aim of this formulation study was to determine the effect of the binder used in the preparation of granules by thermoplastic granulation on the release of propranolol from experimental tablets. Another aim was to select suitable excipients and their ratio in the granules to ensure a trouble-free formulation of the tablets. This study proved that the binder affects the flow properties of the granules, disintegration of the tablets and, subsequently, also the method of drug release, which can be used for the preparation of tablets with modified or prolonged drug release.Kľoc D.Wolaschka T.Ruttkay F.Sciendoarticlethermoplastic granulationpropranolol dissolutionpolyethylene glycolcetyl stearyl alcoholTherapeutics. PharmacologyRM1-950ENEuropean Pharmaceutical Journal, Vol 68, Iss 1, Pp 72-75 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	thermoplastic granulation propranolol dissolution polyethylene glycol cetyl stearyl alcohol Therapeutics. Pharmacology RM1-950
spellingShingle	thermoplastic granulation propranolol dissolution polyethylene glycol cetyl stearyl alcohol Therapeutics. Pharmacology RM1-950 Kľoc D. Wolaschka T. Ruttkay F. Formulation and Evaluation of Tablets Compressed from Granules Prepared by Thermoplastic Granulation
description	The aim of this formulation study was to determine the effect of the binder used in the preparation of granules by thermoplastic granulation on the release of propranolol from experimental tablets. Another aim was to select suitable excipients and their ratio in the granules to ensure a trouble-free formulation of the tablets. This study proved that the binder affects the flow properties of the granules, disintegration of the tablets and, subsequently, also the method of drug release, which can be used for the preparation of tablets with modified or prolonged drug release.
format	article
author	Kľoc D. Wolaschka T. Ruttkay F.
author_facet	Kľoc D. Wolaschka T. Ruttkay F.
author_sort	Kľoc D.
title	Formulation and Evaluation of Tablets Compressed from Granules Prepared by Thermoplastic Granulation
title_short	Formulation and Evaluation of Tablets Compressed from Granules Prepared by Thermoplastic Granulation
title_full	Formulation and Evaluation of Tablets Compressed from Granules Prepared by Thermoplastic Granulation
title_fullStr	Formulation and Evaluation of Tablets Compressed from Granules Prepared by Thermoplastic Granulation
title_full_unstemmed	Formulation and Evaluation of Tablets Compressed from Granules Prepared by Thermoplastic Granulation
title_sort	formulation and evaluation of tablets compressed from granules prepared by thermoplastic granulation
publisher	Sciendo
publishDate	2021
url	https://doaj.org/article/823fe6f29e474180aa45c3735a72f4dc
work_keys_str_mv	AT klocd formulationandevaluationoftabletscompressedfromgranulespreparedbythermoplasticgranulation AT wolaschkat formulationandevaluationoftabletscompressedfromgranulespreparedbythermoplasticgranulation AT ruttkayf formulationandevaluationoftabletscompressedfromgranulespreparedbythermoplasticgranulation
_version_	1718371432091615232

Formulation and Evaluation of Tablets Compressed from Granules Prepared by Thermoplastic Granulation

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