Environmental factors, winter respiratory infections and the seasonal variation in heart failure admissions

Abstract Seasonal cycles of AHF are causally attributed to the seasonal pattern of respiratory tract infections. However, this assumption has never been formally validated. We aimed to determine whether the increase in winter admissions for acute heart failure (AHF) can be explained by seasonal infe...

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Autor principal:	Doron Aronson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/824046350e96486887bd84c949fe795f
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spelling	oai:doaj.org-article:824046350e96486887bd84c949fe795f2021-12-02T15:00:59ZEnvironmental factors, winter respiratory infections and the seasonal variation in heart failure admissions10.1038/s41598-021-90790-72045-2322https://doaj.org/article/824046350e96486887bd84c949fe795f2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-90790-7https://doaj.org/toc/2045-2322Abstract Seasonal cycles of AHF are causally attributed to the seasonal pattern of respiratory tract infections. However, this assumption has never been formally validated. We aimed to determine whether the increase in winter admissions for acute heart failure (AHF) can be explained by seasonal infectious diseases. We studied 12,147 patients admitted for AHF over a period of 11 years (2005–2015). Detailed virology and bacteriology data were collected on each patient. Meteorological information including daily temperature and relative humidity was obtained for the same period. The peak-to-low ratio, indicating the intensity of seasonality, was calculated using negative binomial regression-derived incidence rate ratios (IRR). AHF admissions occurred with a striking annual periodicity, peaking in winter (December-February) and were lowest in summer (June–August), with a seasonal amplitude (January vs. August) of 2.00 ([95% CI 1.79–2.24]. Occurrence of confirmed influenza infections was low (1.59%). Clinical diagnoses of respiratory infections, confirmed influenza infections, and influenza-like infections also followed a strong seasonal pattern (P < 0.0001; Peak/low ratio 2.42 [95% CI 1.394–3.03]). However, after exclusion of all respiratory infections, the seasonal variation in AHF remained robust (Peak/low ratio January vs. August, 1.81 [95% CI 1.60–2.05]; P < 0.0001). There was a strong inverse association between AHF admissions and average monthly temperature (IRR 0.95 per 1℃ increase; 95% CI 0.94 to 0.96). In conclusion, these is a dominant seasonal modulation of AHF admissions which is only partly explained by the incidence of winter respiratory infections. Environmental factors modify the susceptibility of heart failure patients to decompensation.Doron AronsonNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Doron Aronson Environmental factors, winter respiratory infections and the seasonal variation in heart failure admissions
description	Abstract Seasonal cycles of AHF are causally attributed to the seasonal pattern of respiratory tract infections. However, this assumption has never been formally validated. We aimed to determine whether the increase in winter admissions for acute heart failure (AHF) can be explained by seasonal infectious diseases. We studied 12,147 patients admitted for AHF over a period of 11 years (2005–2015). Detailed virology and bacteriology data were collected on each patient. Meteorological information including daily temperature and relative humidity was obtained for the same period. The peak-to-low ratio, indicating the intensity of seasonality, was calculated using negative binomial regression-derived incidence rate ratios (IRR). AHF admissions occurred with a striking annual periodicity, peaking in winter (December-February) and were lowest in summer (June–August), with a seasonal amplitude (January vs. August) of 2.00 ([95% CI 1.79–2.24]. Occurrence of confirmed influenza infections was low (1.59%). Clinical diagnoses of respiratory infections, confirmed influenza infections, and influenza-like infections also followed a strong seasonal pattern (P < 0.0001; Peak/low ratio 2.42 [95% CI 1.394–3.03]). However, after exclusion of all respiratory infections, the seasonal variation in AHF remained robust (Peak/low ratio January vs. August, 1.81 [95% CI 1.60–2.05]; P < 0.0001). There was a strong inverse association between AHF admissions and average monthly temperature (IRR 0.95 per 1℃ increase; 95% CI 0.94 to 0.96). In conclusion, these is a dominant seasonal modulation of AHF admissions which is only partly explained by the incidence of winter respiratory infections. Environmental factors modify the susceptibility of heart failure patients to decompensation.
format	article
author	Doron Aronson
author_facet	Doron Aronson
author_sort	Doron Aronson
title	Environmental factors, winter respiratory infections and the seasonal variation in heart failure admissions
title_short	Environmental factors, winter respiratory infections and the seasonal variation in heart failure admissions
title_full	Environmental factors, winter respiratory infections and the seasonal variation in heart failure admissions
title_fullStr	Environmental factors, winter respiratory infections and the seasonal variation in heart failure admissions
title_full_unstemmed	Environmental factors, winter respiratory infections and the seasonal variation in heart failure admissions
title_sort	environmental factors, winter respiratory infections and the seasonal variation in heart failure admissions
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/824046350e96486887bd84c949fe795f
work_keys_str_mv	AT doronaronson environmentalfactorswinterrespiratoryinfectionsandtheseasonalvariationinheartfailureadmissions
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Environmental factors, winter respiratory infections and the seasonal variation in heart failure admissions

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