Extracellular bacterial lymphatic metastasis drives Streptococcus pyogenes systemic infection

Pathogenic agents can spread from an initial to a secondary site via the lymphatics. Here, using a mouse model of infection, the authors show that S. pyogenes readily transit through sequential lymph nodes within efferent lymphatics to reach the bloodstream and drive systemic infection, while remain...

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Autores principales:	Matthew K. Siggins, Nicola N. Lynskey, Lucy E. Lamb, Louise A. Johnson, Kristin K. Huse, Max Pearson, Suneale Banerji, Claire E. Turner, Kevin Woollard, David G. Jackson, Shiranee Sriskandan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/82442a72732d4568ad2c06ae269341a8
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spelling	oai:doaj.org-article:82442a72732d4568ad2c06ae269341a82021-12-02T15:33:24ZExtracellular bacterial lymphatic metastasis drives Streptococcus pyogenes systemic infection10.1038/s41467-020-18454-02041-1723https://doaj.org/article/82442a72732d4568ad2c06ae269341a82020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18454-0https://doaj.org/toc/2041-1723Pathogenic agents can spread from an initial to a secondary site via the lymphatics. Here, using a mouse model of infection, the authors show that S. pyogenes readily transit through sequential lymph nodes within efferent lymphatics to reach the bloodstream and drive systemic infection, while remaining extracellular.Matthew K. SigginsNicola N. LynskeyLucy E. LambLouise A. JohnsonKristin K. HuseMax PearsonSuneale BanerjiClaire E. TurnerKevin WoollardDavid G. JacksonShiranee SriskandanNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Matthew K. Siggins Nicola N. Lynskey Lucy E. Lamb Louise A. Johnson Kristin K. Huse Max Pearson Suneale Banerji Claire E. Turner Kevin Woollard David G. Jackson Shiranee Sriskandan Extracellular bacterial lymphatic metastasis drives Streptococcus pyogenes systemic infection
description	Pathogenic agents can spread from an initial to a secondary site via the lymphatics. Here, using a mouse model of infection, the authors show that S. pyogenes readily transit through sequential lymph nodes within efferent lymphatics to reach the bloodstream and drive systemic infection, while remaining extracellular.
format	article
author	Matthew K. Siggins Nicola N. Lynskey Lucy E. Lamb Louise A. Johnson Kristin K. Huse Max Pearson Suneale Banerji Claire E. Turner Kevin Woollard David G. Jackson Shiranee Sriskandan
author_facet	Matthew K. Siggins Nicola N. Lynskey Lucy E. Lamb Louise A. Johnson Kristin K. Huse Max Pearson Suneale Banerji Claire E. Turner Kevin Woollard David G. Jackson Shiranee Sriskandan
author_sort	Matthew K. Siggins
title	Extracellular bacterial lymphatic metastasis drives Streptococcus pyogenes systemic infection
title_short	Extracellular bacterial lymphatic metastasis drives Streptococcus pyogenes systemic infection
title_full	Extracellular bacterial lymphatic metastasis drives Streptococcus pyogenes systemic infection
title_fullStr	Extracellular bacterial lymphatic metastasis drives Streptococcus pyogenes systemic infection
title_full_unstemmed	Extracellular bacterial lymphatic metastasis drives Streptococcus pyogenes systemic infection
title_sort	extracellular bacterial lymphatic metastasis drives streptococcus pyogenes systemic infection
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/82442a72732d4568ad2c06ae269341a8
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Extracellular bacterial lymphatic metastasis drives Streptococcus pyogenes systemic infection

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