Hepatocyte Growth Factor Prevented High-Fat Diet-Induced Obesity and Improved Insulin Resistance in Mice

Abstract Obesity and its associated chronic inflammation in adipose tissue initiate insulin resistance, which is related to several pathologies including hypertension and atherosclerosis. Previous reports demonstrated that circulating hepatocyte growth factor (HGF) level was associated with obesity...

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Autores principales:	Jun Muratsu, Masaaki Iwabayashi, Fumihiro Sanada, Yoshiaki Taniyama, Rei Otsu, Hiromi Rakugi, Ryuichi Morishita
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/82442d4d38c943ecb00f89596a73789e
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spelling	oai:doaj.org-article:82442d4d38c943ecb00f89596a73789e2021-12-02T15:05:07ZHepatocyte Growth Factor Prevented High-Fat Diet-Induced Obesity and Improved Insulin Resistance in Mice10.1038/s41598-017-00199-42045-2322https://doaj.org/article/82442d4d38c943ecb00f89596a73789e2017-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-00199-4https://doaj.org/toc/2045-2322Abstract Obesity and its associated chronic inflammation in adipose tissue initiate insulin resistance, which is related to several pathologies including hypertension and atherosclerosis. Previous reports demonstrated that circulating hepatocyte growth factor (HGF) level was associated with obesity and type 2 diabetes. However, its precise role in obesity and related-pathology is unclear. In this experiment, cardiac-specific over-expression of human HGF in mice (HGF-Tg mice) which showed 4–5 times higher serum HGF levels than wild-type mice were used. While body weight in wild-type mice fed with high fat diet (HFD) for 14 weeks was significantly increased accompanied with insulin resistance, HGF-Tg mice prevented body weight gain and insulin resistance. The accumulation of macrophages and elevated levels of inflammatory mediators in adipose tissue were significantly inhibited in HGF-Tg mice as compared to wild-type mice. The HFD-induced obesity in wild-type mice treated with HGF-neutralizing antibody showed an exacerbated response to the glucose tolerance test. These gain-of-function and loss-of-function studies demonstrated that the elevated HGF level induced by HFD have protective role against obesity and insulin resistance.Jun MuratsuMasaaki IwabayashiFumihiro SanadaYoshiaki TaniyamaRei OtsuHiromi RakugiRyuichi MorishitaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-7 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jun Muratsu Masaaki Iwabayashi Fumihiro Sanada Yoshiaki Taniyama Rei Otsu Hiromi Rakugi Ryuichi Morishita Hepatocyte Growth Factor Prevented High-Fat Diet-Induced Obesity and Improved Insulin Resistance in Mice
description	Abstract Obesity and its associated chronic inflammation in adipose tissue initiate insulin resistance, which is related to several pathologies including hypertension and atherosclerosis. Previous reports demonstrated that circulating hepatocyte growth factor (HGF) level was associated with obesity and type 2 diabetes. However, its precise role in obesity and related-pathology is unclear. In this experiment, cardiac-specific over-expression of human HGF in mice (HGF-Tg mice) which showed 4–5 times higher serum HGF levels than wild-type mice were used. While body weight in wild-type mice fed with high fat diet (HFD) for 14 weeks was significantly increased accompanied with insulin resistance, HGF-Tg mice prevented body weight gain and insulin resistance. The accumulation of macrophages and elevated levels of inflammatory mediators in adipose tissue were significantly inhibited in HGF-Tg mice as compared to wild-type mice. The HFD-induced obesity in wild-type mice treated with HGF-neutralizing antibody showed an exacerbated response to the glucose tolerance test. These gain-of-function and loss-of-function studies demonstrated that the elevated HGF level induced by HFD have protective role against obesity and insulin resistance.
format	article
author	Jun Muratsu Masaaki Iwabayashi Fumihiro Sanada Yoshiaki Taniyama Rei Otsu Hiromi Rakugi Ryuichi Morishita
author_facet	Jun Muratsu Masaaki Iwabayashi Fumihiro Sanada Yoshiaki Taniyama Rei Otsu Hiromi Rakugi Ryuichi Morishita
author_sort	Jun Muratsu
title	Hepatocyte Growth Factor Prevented High-Fat Diet-Induced Obesity and Improved Insulin Resistance in Mice
title_short	Hepatocyte Growth Factor Prevented High-Fat Diet-Induced Obesity and Improved Insulin Resistance in Mice
title_full	Hepatocyte Growth Factor Prevented High-Fat Diet-Induced Obesity and Improved Insulin Resistance in Mice
title_fullStr	Hepatocyte Growth Factor Prevented High-Fat Diet-Induced Obesity and Improved Insulin Resistance in Mice
title_full_unstemmed	Hepatocyte Growth Factor Prevented High-Fat Diet-Induced Obesity and Improved Insulin Resistance in Mice
title_sort	hepatocyte growth factor prevented high-fat diet-induced obesity and improved insulin resistance in mice
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/82442d4d38c943ecb00f89596a73789e
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Hepatocyte Growth Factor Prevented High-Fat Diet-Induced Obesity and Improved Insulin Resistance in Mice

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