Trithorax dependent changes in chromatin landscape at enhancer and promoter regions drive female puberty

Before the onset of puberty, Polycomb proteins repress the expression of Kiss1 in KNDy neurons of the arcuate nucleus. Here, by CRISPR-Cas9-directed epigenome editing and RNAi, the authors show that coordinated action of Mll proteins at the Kiss1 promoter and enhancer is required for correct timing...

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Autores principales:	Carlos A. Toro, Hollis Wright, Carlos F. Aylwin, Sergio R. Ojeda, Alejandro Lomniczi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/82454803c8aa42699e49c1370a28eb54
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spelling	oai:doaj.org-article:82454803c8aa42699e49c1370a28eb542021-12-02T15:34:04ZTrithorax dependent changes in chromatin landscape at enhancer and promoter regions drive female puberty10.1038/s41467-017-02512-12041-1723https://doaj.org/article/82454803c8aa42699e49c1370a28eb542018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02512-1https://doaj.org/toc/2041-1723Before the onset of puberty, Polycomb proteins repress the expression of Kiss1 in KNDy neurons of the arcuate nucleus. Here, by CRISPR-Cas9-directed epigenome editing and RNAi, the authors show that coordinated action of Mll proteins at the Kiss1 promoter and enhancer is required for correct timing of puberty.Carlos A. ToroHollis WrightCarlos F. AylwinSergio R. OjedaAlejandro LomnicziNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Carlos A. Toro Hollis Wright Carlos F. Aylwin Sergio R. Ojeda Alejandro Lomniczi Trithorax dependent changes in chromatin landscape at enhancer and promoter regions drive female puberty
description	Before the onset of puberty, Polycomb proteins repress the expression of Kiss1 in KNDy neurons of the arcuate nucleus. Here, by CRISPR-Cas9-directed epigenome editing and RNAi, the authors show that coordinated action of Mll proteins at the Kiss1 promoter and enhancer is required for correct timing of puberty.
format	article
author	Carlos A. Toro Hollis Wright Carlos F. Aylwin Sergio R. Ojeda Alejandro Lomniczi
author_facet	Carlos A. Toro Hollis Wright Carlos F. Aylwin Sergio R. Ojeda Alejandro Lomniczi
author_sort	Carlos A. Toro
title	Trithorax dependent changes in chromatin landscape at enhancer and promoter regions drive female puberty
title_short	Trithorax dependent changes in chromatin landscape at enhancer and promoter regions drive female puberty
title_full	Trithorax dependent changes in chromatin landscape at enhancer and promoter regions drive female puberty
title_fullStr	Trithorax dependent changes in chromatin landscape at enhancer and promoter regions drive female puberty
title_full_unstemmed	Trithorax dependent changes in chromatin landscape at enhancer and promoter regions drive female puberty
title_sort	trithorax dependent changes in chromatin landscape at enhancer and promoter regions drive female puberty
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/82454803c8aa42699e49c1370a28eb54
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Trithorax dependent changes in chromatin landscape at enhancer and promoter regions drive female puberty

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