The expanding role of bendamustine in chronic lymphocytic leukemia

Kruti Sheth Nair, Chaitra Ujjani Lombardi Comprehensive Cancer Center, Medstar Georgetown University Hospital, Washington, DC, USA Abstract: As the most prevalent form of adult leukemia, chronic lymphocytic leukemia (CLL) affects thousands of patients each year. Given the indolent nature of the dis...

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Autores principales:	Nair KS, Ujjani C
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Diseases of the blood and blood-forming organs RC633-647.5
Acceso en línea:	https://doaj.org/article/8248456b825549ceadc69464bedc9655
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spelling	oai:doaj.org-article:8248456b825549ceadc69464bedc96552021-12-02T08:15:18ZThe expanding role of bendamustine in chronic lymphocytic leukemia1179-9889https://doaj.org/article/8248456b825549ceadc69464bedc96552015-07-01T00:00:00Zhttp://www.dovepress.com/the-expanding-role-of-bendamustine-in-chronic-lymphocytic-leukemia-peer-reviewed-article-BLCTThttps://doaj.org/toc/1179-9889Kruti Sheth Nair, Chaitra Ujjani Lombardi Comprehensive Cancer Center, Medstar Georgetown University Hospital, Washington, DC, USA Abstract: As the most prevalent form of adult leukemia, chronic lymphocytic leukemia (CLL) affects thousands of patients each year. Given the indolent nature of the disease, symptomatic patients frequently experience multiple relapses throughout their clinical course. Better therapeutic options are needed, particularly for the elderly population that characterizes the majority of affected patients. Bendamustine, a hybrid alkylating agent, has demonstrated remarkable activity in CLL in conjunction with a tolerable safety profile. Although historically used in relapsed and refractory disease, it has recently gained a role in the front-line setting, including younger, physically fit patients. Current investigatory efforts are focused on exploring the combination of bendamustine with novel therapies in CLL. Keywords: chronic lymphocytic leukemia, overall survival, aspartate aminotransferase, chlorambucil, bendamustineNair KSUjjani CDove Medical PressarticleDiseases of the blood and blood-forming organsRC633-647.5ENBlood and Lymphatic Cancer: Targets and Therapy, Vol 2015, Iss default, Pp 65-74 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the blood and blood-forming organs RC633-647.5
spellingShingle	Diseases of the blood and blood-forming organs RC633-647.5 Nair KS Ujjani C The expanding role of bendamustine in chronic lymphocytic leukemia
description	Kruti Sheth Nair, Chaitra Ujjani Lombardi Comprehensive Cancer Center, Medstar Georgetown University Hospital, Washington, DC, USA Abstract: As the most prevalent form of adult leukemia, chronic lymphocytic leukemia (CLL) affects thousands of patients each year. Given the indolent nature of the disease, symptomatic patients frequently experience multiple relapses throughout their clinical course. Better therapeutic options are needed, particularly for the elderly population that characterizes the majority of affected patients. Bendamustine, a hybrid alkylating agent, has demonstrated remarkable activity in CLL in conjunction with a tolerable safety profile. Although historically used in relapsed and refractory disease, it has recently gained a role in the front-line setting, including younger, physically fit patients. Current investigatory efforts are focused on exploring the combination of bendamustine with novel therapies in CLL. Keywords: chronic lymphocytic leukemia, overall survival, aspartate aminotransferase, chlorambucil, bendamustine
format	article
author	Nair KS Ujjani C
author_facet	Nair KS Ujjani C
author_sort	Nair KS
title	The expanding role of bendamustine in chronic lymphocytic leukemia
title_short	The expanding role of bendamustine in chronic lymphocytic leukemia
title_full	The expanding role of bendamustine in chronic lymphocytic leukemia
title_fullStr	The expanding role of bendamustine in chronic lymphocytic leukemia
title_full_unstemmed	The expanding role of bendamustine in chronic lymphocytic leukemia
title_sort	expanding role of bendamustine in chronic lymphocytic leukemia
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/8248456b825549ceadc69464bedc9655
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The expanding role of bendamustine in chronic lymphocytic leukemia

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