Role of BMI in the Relationship Between Dietary Inflammatory Index and Depression: An Intermediary Analysis
Introduction: This study investigated this association and the role of BMI in the inflammatory process in a large population-based observational study.Methods: A total of 1,865 elderly people (≥55 years) were followed from the Community Cohort Study of Nervous System Diseases (CCSNSD) cohort study f...
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Frontiers Media S.A.
2021
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oai:doaj.org-article:824b3ea76f354a44a58bf16cc6e337f42021-11-15T06:42:28ZRole of BMI in the Relationship Between Dietary Inflammatory Index and Depression: An Intermediary Analysis2296-858X10.3389/fmed.2021.748788https://doaj.org/article/824b3ea76f354a44a58bf16cc6e337f42021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fmed.2021.748788/fullhttps://doaj.org/toc/2296-858XIntroduction: This study investigated this association and the role of BMI in the inflammatory process in a large population-based observational study.Methods: A total of 1,865 elderly people (≥55 years) were followed from the Community Cohort Study of Nervous System Diseases (CCSNSD) cohort study from 2018 to 2019 (Mean [SD] age, 66.31 [0.32] years; 716 [38.4%] males). The semi-quantitative FFQ and geriatric depression scale (GDS) were used to evaluate the diet and depressive symptoms of the elderly, respectively. The multivariable logistic regression model estimated the OR and 95% CI between Empirical Dietary Inflammatory Index (E-DII) and depression. The interaction of E-DII and BMI on depressive events was tested, and the mediation analysis of BMI was performed.Results: As measured by E-DII, the mean (SE) value of the inflammatory potential of the diet in our study was 1.56 (0.12). E-DII ranged from 5.23 to 5.58. In comparison with the first quartile, the elderly from the second quartile (OR: 1.15 [95% CI: 1.09, 1.28]) to the fourth quartile (OR: 1.31 [95% CI: 1.16, 1.42]) have a higher risk of depression before adjustment for BMI. An interaction was observed between E-DII and BMI in terms of the risk of depression (PInteraction < 0.001). The whole related part is mediated by BMI (31.06%).Conclusion: Our findings indicate that the higher pro-inflammatory potential of diet is associated with a higher risk of depression, and this association may be mediated by BMI. Further research is needed to verify our findings and clarify the latent mechanism.Yuxia MaRuiqiang LiWenqiang ZhanXin HuangZechen ZhangShuaishuai LvJiaqi WangLuyao LiangXiaofang JiaFrontiers Media S.A.articledietary inflammatory indexdepressionbody mass indexmediation analysisdietMedicine (General)R5-920ENFrontiers in Medicine, Vol 8 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
dietary inflammatory index depression body mass index mediation analysis diet Medicine (General) R5-920 |
| spellingShingle |
dietary inflammatory index depression body mass index mediation analysis diet Medicine (General) R5-920 Yuxia Ma Ruiqiang Li Wenqiang Zhan Xin Huang Zechen Zhang Shuaishuai Lv Jiaqi Wang Luyao Liang Xiaofang Jia Role of BMI in the Relationship Between Dietary Inflammatory Index and Depression: An Intermediary Analysis |
| description |
Introduction: This study investigated this association and the role of BMI in the inflammatory process in a large population-based observational study.Methods: A total of 1,865 elderly people (≥55 years) were followed from the Community Cohort Study of Nervous System Diseases (CCSNSD) cohort study from 2018 to 2019 (Mean [SD] age, 66.31 [0.32] years; 716 [38.4%] males). The semi-quantitative FFQ and geriatric depression scale (GDS) were used to evaluate the diet and depressive symptoms of the elderly, respectively. The multivariable logistic regression model estimated the OR and 95% CI between Empirical Dietary Inflammatory Index (E-DII) and depression. The interaction of E-DII and BMI on depressive events was tested, and the mediation analysis of BMI was performed.Results: As measured by E-DII, the mean (SE) value of the inflammatory potential of the diet in our study was 1.56 (0.12). E-DII ranged from 5.23 to 5.58. In comparison with the first quartile, the elderly from the second quartile (OR: 1.15 [95% CI: 1.09, 1.28]) to the fourth quartile (OR: 1.31 [95% CI: 1.16, 1.42]) have a higher risk of depression before adjustment for BMI. An interaction was observed between E-DII and BMI in terms of the risk of depression (PInteraction < 0.001). The whole related part is mediated by BMI (31.06%).Conclusion: Our findings indicate that the higher pro-inflammatory potential of diet is associated with a higher risk of depression, and this association may be mediated by BMI. Further research is needed to verify our findings and clarify the latent mechanism. |
| format |
article |
| author |
Yuxia Ma Ruiqiang Li Wenqiang Zhan Xin Huang Zechen Zhang Shuaishuai Lv Jiaqi Wang Luyao Liang Xiaofang Jia |
| author_facet |
Yuxia Ma Ruiqiang Li Wenqiang Zhan Xin Huang Zechen Zhang Shuaishuai Lv Jiaqi Wang Luyao Liang Xiaofang Jia |
| author_sort |
Yuxia Ma |
| title |
Role of BMI in the Relationship Between Dietary Inflammatory Index and Depression: An Intermediary Analysis |
| title_short |
Role of BMI in the Relationship Between Dietary Inflammatory Index and Depression: An Intermediary Analysis |
| title_full |
Role of BMI in the Relationship Between Dietary Inflammatory Index and Depression: An Intermediary Analysis |
| title_fullStr |
Role of BMI in the Relationship Between Dietary Inflammatory Index and Depression: An Intermediary Analysis |
| title_full_unstemmed |
Role of BMI in the Relationship Between Dietary Inflammatory Index and Depression: An Intermediary Analysis |
| title_sort |
role of bmi in the relationship between dietary inflammatory index and depression: an intermediary analysis |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/824b3ea76f354a44a58bf16cc6e337f4 |
| work_keys_str_mv |
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