The interplay between vaccination and social distancing strategies affects COVID19 population-level outcomes.

Social distancing is an effective population-level mitigation strategy to prevent COVID19 propagation but it does not reduce the number of susceptible individuals and bears severe social consequences-a dire situation that can be overcome with the recently developed vaccines. Although a combination o...

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Autores principales:	Sharon Guerstein, Victoria Romeo-Aznar, Ma'ayan Dekel, Oren Miron, Nadav Davidovitch, Rami Puzis, Shai Pilosof
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/824b78a8d8af43b980ea9538a83b082f
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spelling	oai:doaj.org-article:824b78a8d8af43b980ea9538a83b082f2021-12-02T19:58:02ZThe interplay between vaccination and social distancing strategies affects COVID19 population-level outcomes.1553-734X1553-735810.1371/journal.pcbi.1009319https://doaj.org/article/824b78a8d8af43b980ea9538a83b082f2021-08-01T00:00:00Zhttps://doi.org/10.1371/journal.pcbi.1009319https://doaj.org/toc/1553-734Xhttps://doaj.org/toc/1553-7358Social distancing is an effective population-level mitigation strategy to prevent COVID19 propagation but it does not reduce the number of susceptible individuals and bears severe social consequences-a dire situation that can be overcome with the recently developed vaccines. Although a combination of these interventions should provide greater benefits than their isolated deployment, a mechanistic understanding of the interplay between them is missing. To tackle this challenge we developed an age-structured deterministic model in which vaccines are deployed during the pandemic to individuals who do not show symptoms. The model allows for flexible and dynamic prioritization strategies with shifts between target groups. We find a strong interaction between social distancing and vaccination in their effect on the proportion of hospitalizations. In particular, prioritizing vaccines to elderly (60+) before adults (20-59) is more effective when social distancing is applied to adults or uniformly. In addition, the temporal reproductive number Rt is only affected by vaccines when deployed at sufficiently high rates and in tandem with social distancing. Finally, the same reduction in hospitalization can be achieved via different combination of strategies, giving decision makers flexibility in choosing public health policies. Our study provides insights into the factors that affect vaccination success and provides methodology to test different intervention strategies in a way that will align with ethical guidelines.Sharon GuersteinVictoria Romeo-AznarMa'ayan DekelOren MironNadav DavidovitchRami PuzisShai PilosofPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Computational Biology, Vol 17, Iss 8, p e1009319 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Sharon Guerstein Victoria Romeo-Aznar Ma'ayan Dekel Oren Miron Nadav Davidovitch Rami Puzis Shai Pilosof The interplay between vaccination and social distancing strategies affects COVID19 population-level outcomes.
description	Social distancing is an effective population-level mitigation strategy to prevent COVID19 propagation but it does not reduce the number of susceptible individuals and bears severe social consequences-a dire situation that can be overcome with the recently developed vaccines. Although a combination of these interventions should provide greater benefits than their isolated deployment, a mechanistic understanding of the interplay between them is missing. To tackle this challenge we developed an age-structured deterministic model in which vaccines are deployed during the pandemic to individuals who do not show symptoms. The model allows for flexible and dynamic prioritization strategies with shifts between target groups. We find a strong interaction between social distancing and vaccination in their effect on the proportion of hospitalizations. In particular, prioritizing vaccines to elderly (60+) before adults (20-59) is more effective when social distancing is applied to adults or uniformly. In addition, the temporal reproductive number Rt is only affected by vaccines when deployed at sufficiently high rates and in tandem with social distancing. Finally, the same reduction in hospitalization can be achieved via different combination of strategies, giving decision makers flexibility in choosing public health policies. Our study provides insights into the factors that affect vaccination success and provides methodology to test different intervention strategies in a way that will align with ethical guidelines.
format	article
author	Sharon Guerstein Victoria Romeo-Aznar Ma'ayan Dekel Oren Miron Nadav Davidovitch Rami Puzis Shai Pilosof
author_facet	Sharon Guerstein Victoria Romeo-Aznar Ma'ayan Dekel Oren Miron Nadav Davidovitch Rami Puzis Shai Pilosof
author_sort	Sharon Guerstein
title	The interplay between vaccination and social distancing strategies affects COVID19 population-level outcomes.
title_short	The interplay between vaccination and social distancing strategies affects COVID19 population-level outcomes.
title_full	The interplay between vaccination and social distancing strategies affects COVID19 population-level outcomes.
title_fullStr	The interplay between vaccination and social distancing strategies affects COVID19 population-level outcomes.
title_full_unstemmed	The interplay between vaccination and social distancing strategies affects COVID19 population-level outcomes.
title_sort	interplay between vaccination and social distancing strategies affects covid19 population-level outcomes.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/824b78a8d8af43b980ea9538a83b082f
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The interplay between vaccination and social distancing strategies affects COVID19 population-level outcomes.

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