High loading of trimethylglycine promotes aqueous solubility of poorly water-soluble cisplatin

Abstract Trimethylglycine (TMG) is a cheap, natural, and highly biocompatible compound. Therefore, it has been used in the fields of food and life sciences, but the application of solid TMG is limited to utilisation as an “additive”. In the present study, we focussed on the high solubility of TMG in...

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Autores principales:	Riki Kadokawa, Tetsuo Fujie, Gyanendra Sharma, Kojiro Ishibashi, Kazuaki Ninomiya, Kenji Takahashi, Eishu Hirata, Kosuke Kuroda
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8250c6de5dab40d5b67f7e837fecc7fa
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spelling	oai:doaj.org-article:8250c6de5dab40d5b67f7e837fecc7fa2021-12-02T14:49:25ZHigh loading of trimethylglycine promotes aqueous solubility of poorly water-soluble cisplatin10.1038/s41598-021-89144-02045-2322https://doaj.org/article/8250c6de5dab40d5b67f7e837fecc7fa2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-89144-0https://doaj.org/toc/2045-2322Abstract Trimethylglycine (TMG) is a cheap, natural, and highly biocompatible compound. Therefore, it has been used in the fields of food and life sciences, but the application of solid TMG is limited to utilisation as an “additive”. In the present study, we focussed on the high solubility of TMG in water, derived from the aprotic zwitterionic structure, and proposed TMG as the chemical accounting for a major portion of the aqueous solution (e.g., 50 wt%). High loading of TMG shifted the properties of water and enabled the dissolution of poorly water-soluble cisplatin, an anticancer agent, at high concentration (solubility of cisplatin: 0.15 wt% in water vs 1.7 wt% in TMG aqueous solution). For hepatic arterial infusion, this can reduce the amount of cisplatin administered from 40 to 4 mL. It enables simple injection using a syringe, without the need for catheters and automatic pumps, leading to critical alleviation of the risk to patients. Furthermore, we produced a dry powder from a cisplatin-containing TMG aqueous solution via freeze-drying. Powders can be conveniently stored and transported. Furthermore, cisplatin is often used as a mixture with other drugs, and cisplatin aqueous solutions are not preferred as they dilute the other drugs.Riki KadokawaTetsuo FujieGyanendra SharmaKojiro IshibashiKazuaki NinomiyaKenji TakahashiEishu HirataKosuke KurodaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-6 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Riki Kadokawa Tetsuo Fujie Gyanendra Sharma Kojiro Ishibashi Kazuaki Ninomiya Kenji Takahashi Eishu Hirata Kosuke Kuroda High loading of trimethylglycine promotes aqueous solubility of poorly water-soluble cisplatin
description	Abstract Trimethylglycine (TMG) is a cheap, natural, and highly biocompatible compound. Therefore, it has been used in the fields of food and life sciences, but the application of solid TMG is limited to utilisation as an “additive”. In the present study, we focussed on the high solubility of TMG in water, derived from the aprotic zwitterionic structure, and proposed TMG as the chemical accounting for a major portion of the aqueous solution (e.g., 50 wt%). High loading of TMG shifted the properties of water and enabled the dissolution of poorly water-soluble cisplatin, an anticancer agent, at high concentration (solubility of cisplatin: 0.15 wt% in water vs 1.7 wt% in TMG aqueous solution). For hepatic arterial infusion, this can reduce the amount of cisplatin administered from 40 to 4 mL. It enables simple injection using a syringe, without the need for catheters and automatic pumps, leading to critical alleviation of the risk to patients. Furthermore, we produced a dry powder from a cisplatin-containing TMG aqueous solution via freeze-drying. Powders can be conveniently stored and transported. Furthermore, cisplatin is often used as a mixture with other drugs, and cisplatin aqueous solutions are not preferred as they dilute the other drugs.
format	article
author	Riki Kadokawa Tetsuo Fujie Gyanendra Sharma Kojiro Ishibashi Kazuaki Ninomiya Kenji Takahashi Eishu Hirata Kosuke Kuroda
author_facet	Riki Kadokawa Tetsuo Fujie Gyanendra Sharma Kojiro Ishibashi Kazuaki Ninomiya Kenji Takahashi Eishu Hirata Kosuke Kuroda
author_sort	Riki Kadokawa
title	High loading of trimethylglycine promotes aqueous solubility of poorly water-soluble cisplatin
title_short	High loading of trimethylglycine promotes aqueous solubility of poorly water-soluble cisplatin
title_full	High loading of trimethylglycine promotes aqueous solubility of poorly water-soluble cisplatin
title_fullStr	High loading of trimethylglycine promotes aqueous solubility of poorly water-soluble cisplatin
title_full_unstemmed	High loading of trimethylglycine promotes aqueous solubility of poorly water-soluble cisplatin
title_sort	high loading of trimethylglycine promotes aqueous solubility of poorly water-soluble cisplatin
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/8250c6de5dab40d5b67f7e837fecc7fa
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High loading of trimethylglycine promotes aqueous solubility of poorly water-soluble cisplatin

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