Body mass index and serum proteomic profile in breast cancer and healthy women: a prospective study.

Epidemiological studies suggest a possible association between BMI, diagnosis and clinical-pathological breast cancer characteristics but biological bases for this relationship still remain to be ascertained. Several biological mechanisms play a role in the genesis and progression of breast cancer....

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Autores principales:	Vito Michele Garrisi, Antonio Tufaro, Paolo Trerotoli, Italia Bongarzone, Michele Quaranta, Vincenzo Ventrella, Stefania Tommasi, Gianluigi Giannelli, Angelo Paradiso
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/82517979886b46299df449953638caab
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spelling	oai:doaj.org-article:82517979886b46299df449953638caab2021-11-18T08:06:58ZBody mass index and serum proteomic profile in breast cancer and healthy women: a prospective study.1932-620310.1371/journal.pone.0049631https://doaj.org/article/82517979886b46299df449953638caab2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23226214/?tool=EBIhttps://doaj.org/toc/1932-6203Epidemiological studies suggest a possible association between BMI, diagnosis and clinical-pathological breast cancer characteristics but biological bases for this relationship still remain to be ascertained. Several biological mechanisms play a role in the genesis and progression of breast cancer. This study aimed to investigate relationships between BMI and breast cancer diagnosis/progression in a Southern Italian population and to try to interpret results according to the serum proteomic profile of healthy and breast cancer patients. BMI, presence or absence of breast cancer and its clinical-pathological characteristics were analyzed in a series of 300 breast cancer women and compared with those of 300 healthy women prospectively. To investigate whether obesity is associated with alterations in serum protein profile, SELDI-ToF approach was applied.Alcohol consumption (22.7% vs 11.3%; p<0.001) and postmenopausal status (65.7% vs 52%; p<0.001) but not BMI resulted significantly different in patients vs controls. Conversely, BMI was significantly associated with a larger-tumour size (BMI> = 30 respect to normal weight: OR = 2.49, 95% CI 1.25-4.99, p = 0.0098) and a higher probability of having positive axillary lymph node (OR = 3.67, CI 95% 2.16-6.23, p<0.0001). Multivariate analysis confirmed the association of breast cancer diagnosis with alcohol consumption (OR = 2.28;CI 1.36-3.83; p<0.0018). Serum protein profile revealed the presence of significant (p-value <0,01) differentially expressed peaks m/z 6934, m/z 5066 in high BMI breast cancer patients vs healthy subjects and m/z 6934, m/z 3346 in high vs low BMI breast cancer patients.The analysis of pathological features of cancer indicates that normal weight women have a significantly higher probability of having a smaller breast cancer at time of diagnosis and negative axillary lymph nodes while increased BMI is associated with an altered protein profile in breast cancer patients. Further studies to identify specific proteins found in the serum and their role in breast cancerogenesis and progression are in progress.Vito Michele GarrisiAntonio TufaroPaolo TrerotoliItalia BongarzoneMichele QuarantaVincenzo VentrellaStefania TommasiGianluigi GiannelliAngelo ParadisoPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 11, p e49631 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Vito Michele Garrisi Antonio Tufaro Paolo Trerotoli Italia Bongarzone Michele Quaranta Vincenzo Ventrella Stefania Tommasi Gianluigi Giannelli Angelo Paradiso Body mass index and serum proteomic profile in breast cancer and healthy women: a prospective study.
description	Epidemiological studies suggest a possible association between BMI, diagnosis and clinical-pathological breast cancer characteristics but biological bases for this relationship still remain to be ascertained. Several biological mechanisms play a role in the genesis and progression of breast cancer. This study aimed to investigate relationships between BMI and breast cancer diagnosis/progression in a Southern Italian population and to try to interpret results according to the serum proteomic profile of healthy and breast cancer patients. BMI, presence or absence of breast cancer and its clinical-pathological characteristics were analyzed in a series of 300 breast cancer women and compared with those of 300 healthy women prospectively. To investigate whether obesity is associated with alterations in serum protein profile, SELDI-ToF approach was applied.Alcohol consumption (22.7% vs 11.3%; p<0.001) and postmenopausal status (65.7% vs 52%; p<0.001) but not BMI resulted significantly different in patients vs controls. Conversely, BMI was significantly associated with a larger-tumour size (BMI> = 30 respect to normal weight: OR = 2.49, 95% CI 1.25-4.99, p = 0.0098) and a higher probability of having positive axillary lymph node (OR = 3.67, CI 95% 2.16-6.23, p<0.0001). Multivariate analysis confirmed the association of breast cancer diagnosis with alcohol consumption (OR = 2.28;CI 1.36-3.83; p<0.0018). Serum protein profile revealed the presence of significant (p-value <0,01) differentially expressed peaks m/z 6934, m/z 5066 in high BMI breast cancer patients vs healthy subjects and m/z 6934, m/z 3346 in high vs low BMI breast cancer patients.The analysis of pathological features of cancer indicates that normal weight women have a significantly higher probability of having a smaller breast cancer at time of diagnosis and negative axillary lymph nodes while increased BMI is associated with an altered protein profile in breast cancer patients. Further studies to identify specific proteins found in the serum and their role in breast cancerogenesis and progression are in progress.
format	article
author	Vito Michele Garrisi Antonio Tufaro Paolo Trerotoli Italia Bongarzone Michele Quaranta Vincenzo Ventrella Stefania Tommasi Gianluigi Giannelli Angelo Paradiso
author_facet	Vito Michele Garrisi Antonio Tufaro Paolo Trerotoli Italia Bongarzone Michele Quaranta Vincenzo Ventrella Stefania Tommasi Gianluigi Giannelli Angelo Paradiso
author_sort	Vito Michele Garrisi
title	Body mass index and serum proteomic profile in breast cancer and healthy women: a prospective study.
title_short	Body mass index and serum proteomic profile in breast cancer and healthy women: a prospective study.
title_full	Body mass index and serum proteomic profile in breast cancer and healthy women: a prospective study.
title_fullStr	Body mass index and serum proteomic profile in breast cancer and healthy women: a prospective study.
title_full_unstemmed	Body mass index and serum proteomic profile in breast cancer and healthy women: a prospective study.
title_sort	body mass index and serum proteomic profile in breast cancer and healthy women: a prospective study.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/82517979886b46299df449953638caab
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Body mass index and serum proteomic profile in breast cancer and healthy women: a prospective study.

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