Structural identification of N-glycan isomers using logically derived sequence tandem mass spectrometry

Mass spectrometry can be used for structural determination of N-glycans, but commonly requires prior derivatisation or comparison to a library of standards. Here logically-derived sequence tandem mass spectrometry allows for assignment of native N-glycans by analysis of successive fragmentation patt...

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Autores principales: Chia Yen Liew, Chu-Chun Yen, Jien-Lian Chen, Shang-Ting Tsai, Sujeet Pawar, Chung-Yi Wu, Chi-Kung Ni
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/8253fbb5f0b24bfb8e4abc3ad6bd08f4
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spelling oai:doaj.org-article:8253fbb5f0b24bfb8e4abc3ad6bd08f42021-12-02T16:04:20ZStructural identification of N-glycan isomers using logically derived sequence tandem mass spectrometry10.1038/s42004-021-00532-z2399-3669https://doaj.org/article/8253fbb5f0b24bfb8e4abc3ad6bd08f42021-06-01T00:00:00Zhttps://doi.org/10.1038/s42004-021-00532-zhttps://doaj.org/toc/2399-3669Mass spectrometry can be used for structural determination of N-glycans, but commonly requires prior derivatisation or comparison to a library of standards. Here logically-derived sequence tandem mass spectrometry allows for assignment of native N-glycans by analysis of successive fragmentation patterns without derivatisation and standards.Chia Yen LiewChu-Chun YenJien-Lian ChenShang-Ting TsaiSujeet PawarChung-Yi WuChi-Kung NiNature PortfolioarticleChemistryQD1-999ENCommunications Chemistry, Vol 4, Iss 1, Pp 1-11 (2021)
institution DOAJ
collection DOAJ
language EN
topic Chemistry
QD1-999
spellingShingle Chemistry
QD1-999
Chia Yen Liew
Chu-Chun Yen
Jien-Lian Chen
Shang-Ting Tsai
Sujeet Pawar
Chung-Yi Wu
Chi-Kung Ni
Structural identification of N-glycan isomers using logically derived sequence tandem mass spectrometry
description Mass spectrometry can be used for structural determination of N-glycans, but commonly requires prior derivatisation or comparison to a library of standards. Here logically-derived sequence tandem mass spectrometry allows for assignment of native N-glycans by analysis of successive fragmentation patterns without derivatisation and standards.
format article
author Chia Yen Liew
Chu-Chun Yen
Jien-Lian Chen
Shang-Ting Tsai
Sujeet Pawar
Chung-Yi Wu
Chi-Kung Ni
author_facet Chia Yen Liew
Chu-Chun Yen
Jien-Lian Chen
Shang-Ting Tsai
Sujeet Pawar
Chung-Yi Wu
Chi-Kung Ni
author_sort Chia Yen Liew
title Structural identification of N-glycan isomers using logically derived sequence tandem mass spectrometry
title_short Structural identification of N-glycan isomers using logically derived sequence tandem mass spectrometry
title_full Structural identification of N-glycan isomers using logically derived sequence tandem mass spectrometry
title_fullStr Structural identification of N-glycan isomers using logically derived sequence tandem mass spectrometry
title_full_unstemmed Structural identification of N-glycan isomers using logically derived sequence tandem mass spectrometry
title_sort structural identification of n-glycan isomers using logically derived sequence tandem mass spectrometry
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/8253fbb5f0b24bfb8e4abc3ad6bd08f4
work_keys_str_mv AT chiayenliew structuralidentificationofnglycanisomersusinglogicallyderivedsequencetandemmassspectrometry
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AT jienlianchen structuralidentificationofnglycanisomersusinglogicallyderivedsequencetandemmassspectrometry
AT shangtingtsai structuralidentificationofnglycanisomersusinglogicallyderivedsequencetandemmassspectrometry
AT sujeetpawar structuralidentificationofnglycanisomersusinglogicallyderivedsequencetandemmassspectrometry
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