Transcriptomic analysis of atopic dermatitis in African Americans is characterized by Th2/Th17-centered cutaneous immune activation

Abstract Atopic dermatitis (AD) often presents more severely in African Americans (AAs) and with greater involvement of extensor areas. To investigate immune signatures of AD in AAs with moderate to severe pruritus, lesional and non-lesional punch biopsies were taken from AA patients along with age-...

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Autores principales:	Shannon Wongvibulsin, Nishadh Sutaria, Suraj Kannan, Martin Prince Alphonse, Micah Belzberg, Kyle A. Williams, Isabelle D. Brown, Justin Choi, Youkyung Sophie Roh, Thomas Pritchard, Raveena Khanna, Amarachi C. Eseonu, Jaroslaw Jedrych, Carly Dillen, Madan M. Kwatra, Anna L. Chien, Nathan Archer, Luis A. Garza, Xinzhong Dong, Sewon Kang, Shawn G. Kwatra
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/82598be293ef423d9b1d4aa391ce6e81
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spelling	oai:doaj.org-article:82598be293ef423d9b1d4aa391ce6e812021-12-02T15:00:40ZTranscriptomic analysis of atopic dermatitis in African Americans is characterized by Th2/Th17-centered cutaneous immune activation10.1038/s41598-021-90105-w2045-2322https://doaj.org/article/82598be293ef423d9b1d4aa391ce6e812021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-90105-whttps://doaj.org/toc/2045-2322Abstract Atopic dermatitis (AD) often presents more severely in African Americans (AAs) and with greater involvement of extensor areas. To investigate immune signatures of AD in AAs with moderate to severe pruritus, lesional and non-lesional punch biopsies were taken from AA patients along with age-, race-, and sex-matched controls. Histology of lesional skin showed psoriasiform dermatitis and spongiotic dermatitis, suggesting both Th2 and Th17 activity. Gene Set Variation Analysis showed upregulation of Th2 and Th17 pathways in both lesional versus non-lesional and lesional versus control (p < 0.01), while Th1 and Th22 upregulation were observed in lesional versus control (p < 0.05). Evidence for a broad immune signature also was supported by upregulated Th1 and Th22 pathways, and clinically may represent greater severity of AD in AA. Furthermore, population-level analysis of data from TriNetX, a global federated health research network, revealed that AA AD patients had higher values for CRP, ferritin, and blood eosinophils compared to age-, sex-, and race-matched controls as well as white AD patients, suggesting broad systemic inflammation. Therefore, AA AD patients may feature broader immune activation than previously thought and may derive benefit from systemic immunomodulating therapies that modulate key drivers of multiple immune pathways.Shannon WongvibulsinNishadh SutariaSuraj KannanMartin Prince AlphonseMicah BelzbergKyle A. WilliamsIsabelle D. BrownJustin ChoiYoukyung Sophie RohThomas PritchardRaveena KhannaAmarachi C. EseonuJaroslaw JedrychCarly DillenMadan M. KwatraAnna L. ChienNathan ArcherLuis A. GarzaXinzhong DongSewon KangShawn G. KwatraNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Shannon Wongvibulsin Nishadh Sutaria Suraj Kannan Martin Prince Alphonse Micah Belzberg Kyle A. Williams Isabelle D. Brown Justin Choi Youkyung Sophie Roh Thomas Pritchard Raveena Khanna Amarachi C. Eseonu Jaroslaw Jedrych Carly Dillen Madan M. Kwatra Anna L. Chien Nathan Archer Luis A. Garza Xinzhong Dong Sewon Kang Shawn G. Kwatra Transcriptomic analysis of atopic dermatitis in African Americans is characterized by Th2/Th17-centered cutaneous immune activation
description	Abstract Atopic dermatitis (AD) often presents more severely in African Americans (AAs) and with greater involvement of extensor areas. To investigate immune signatures of AD in AAs with moderate to severe pruritus, lesional and non-lesional punch biopsies were taken from AA patients along with age-, race-, and sex-matched controls. Histology of lesional skin showed psoriasiform dermatitis and spongiotic dermatitis, suggesting both Th2 and Th17 activity. Gene Set Variation Analysis showed upregulation of Th2 and Th17 pathways in both lesional versus non-lesional and lesional versus control (p < 0.01), while Th1 and Th22 upregulation were observed in lesional versus control (p < 0.05). Evidence for a broad immune signature also was supported by upregulated Th1 and Th22 pathways, and clinically may represent greater severity of AD in AA. Furthermore, population-level analysis of data from TriNetX, a global federated health research network, revealed that AA AD patients had higher values for CRP, ferritin, and blood eosinophils compared to age-, sex-, and race-matched controls as well as white AD patients, suggesting broad systemic inflammation. Therefore, AA AD patients may feature broader immune activation than previously thought and may derive benefit from systemic immunomodulating therapies that modulate key drivers of multiple immune pathways.
format	article
author	Shannon Wongvibulsin Nishadh Sutaria Suraj Kannan Martin Prince Alphonse Micah Belzberg Kyle A. Williams Isabelle D. Brown Justin Choi Youkyung Sophie Roh Thomas Pritchard Raveena Khanna Amarachi C. Eseonu Jaroslaw Jedrych Carly Dillen Madan M. Kwatra Anna L. Chien Nathan Archer Luis A. Garza Xinzhong Dong Sewon Kang Shawn G. Kwatra
author_facet	Shannon Wongvibulsin Nishadh Sutaria Suraj Kannan Martin Prince Alphonse Micah Belzberg Kyle A. Williams Isabelle D. Brown Justin Choi Youkyung Sophie Roh Thomas Pritchard Raveena Khanna Amarachi C. Eseonu Jaroslaw Jedrych Carly Dillen Madan M. Kwatra Anna L. Chien Nathan Archer Luis A. Garza Xinzhong Dong Sewon Kang Shawn G. Kwatra
author_sort	Shannon Wongvibulsin
title	Transcriptomic analysis of atopic dermatitis in African Americans is characterized by Th2/Th17-centered cutaneous immune activation
title_short	Transcriptomic analysis of atopic dermatitis in African Americans is characterized by Th2/Th17-centered cutaneous immune activation
title_full	Transcriptomic analysis of atopic dermatitis in African Americans is characterized by Th2/Th17-centered cutaneous immune activation
title_fullStr	Transcriptomic analysis of atopic dermatitis in African Americans is characterized by Th2/Th17-centered cutaneous immune activation
title_full_unstemmed	Transcriptomic analysis of atopic dermatitis in African Americans is characterized by Th2/Th17-centered cutaneous immune activation
title_sort	transcriptomic analysis of atopic dermatitis in african americans is characterized by th2/th17-centered cutaneous immune activation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/82598be293ef423d9b1d4aa391ce6e81
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Transcriptomic analysis of atopic dermatitis in African Americans is characterized by Th2/Th17-centered cutaneous immune activation

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