The Role of Glucocorticoids in Inflammatory Diseases

For more than 70 years, glucocorticoids (GCs) have been a powerful and affordable treatment option for inflammatory diseases. However, their benefits do not come without a cost, since GCs also cause side effects. Therefore, strong efforts are being made to improve their therapeutic index. In this re...

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Autores principales:	Sybille D. Reichardt, Agathe Amouret, Chiara Muzzi, Sabine Vettorazzi, Jan P. Tuckermann, Fred Lühder, Holger M. Reichardt
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	glucocorticoid receptor multiple sclerosis inflammatory bowel disease asthma acute lung injury rheumatoid arthritis Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/8259bbf6ae884f8d95dec4607745f541
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id	oai:doaj.org-article:8259bbf6ae884f8d95dec4607745f541
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spelling	oai:doaj.org-article:8259bbf6ae884f8d95dec4607745f5412021-11-25T17:08:54ZThe Role of Glucocorticoids in Inflammatory Diseases10.3390/cells101129212073-4409https://doaj.org/article/8259bbf6ae884f8d95dec4607745f5412021-10-01T00:00:00Zhttps://www.mdpi.com/2073-4409/10/11/2921https://doaj.org/toc/2073-4409For more than 70 years, glucocorticoids (GCs) have been a powerful and affordable treatment option for inflammatory diseases. However, their benefits do not come without a cost, since GCs also cause side effects. Therefore, strong efforts are being made to improve their therapeutic index. In this review, we illustrate the mechanisms and target cells of GCs in the pathogenesis and treatment of some of the most frequent inflammatory disorders affecting the central nervous system, the gastrointestinal tract, the lung, and the joints, as well as graft-versus-host disease, which often develops after hematopoietic stem cell transplantation. In addition, an overview is provided of novel approaches aimed at improving GC therapy based on chemical modifications or GC delivery using nanoformulations. GCs remain a topic of highly active scientific research despite being one of the oldest class of drugs in medical use.Sybille D. ReichardtAgathe AmouretChiara MuzziSabine VettorazziJan P. TuckermannFred LühderHolger M. ReichardtMDPI AGarticleglucocorticoid receptormultiple sclerosisinflammatory bowel diseaseasthmaacute lung injuryrheumatoid arthritisBiology (General)QH301-705.5ENCells, Vol 10, Iss 2921, p 2921 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	glucocorticoid receptor multiple sclerosis inflammatory bowel disease asthma acute lung injury rheumatoid arthritis Biology (General) QH301-705.5
spellingShingle	glucocorticoid receptor multiple sclerosis inflammatory bowel disease asthma acute lung injury rheumatoid arthritis Biology (General) QH301-705.5 Sybille D. Reichardt Agathe Amouret Chiara Muzzi Sabine Vettorazzi Jan P. Tuckermann Fred Lühder Holger M. Reichardt The Role of Glucocorticoids in Inflammatory Diseases
description	For more than 70 years, glucocorticoids (GCs) have been a powerful and affordable treatment option for inflammatory diseases. However, their benefits do not come without a cost, since GCs also cause side effects. Therefore, strong efforts are being made to improve their therapeutic index. In this review, we illustrate the mechanisms and target cells of GCs in the pathogenesis and treatment of some of the most frequent inflammatory disorders affecting the central nervous system, the gastrointestinal tract, the lung, and the joints, as well as graft-versus-host disease, which often develops after hematopoietic stem cell transplantation. In addition, an overview is provided of novel approaches aimed at improving GC therapy based on chemical modifications or GC delivery using nanoformulations. GCs remain a topic of highly active scientific research despite being one of the oldest class of drugs in medical use.
format	article
author	Sybille D. Reichardt Agathe Amouret Chiara Muzzi Sabine Vettorazzi Jan P. Tuckermann Fred Lühder Holger M. Reichardt
author_facet	Sybille D. Reichardt Agathe Amouret Chiara Muzzi Sabine Vettorazzi Jan P. Tuckermann Fred Lühder Holger M. Reichardt
author_sort	Sybille D. Reichardt
title	The Role of Glucocorticoids in Inflammatory Diseases
title_short	The Role of Glucocorticoids in Inflammatory Diseases
title_full	The Role of Glucocorticoids in Inflammatory Diseases
title_fullStr	The Role of Glucocorticoids in Inflammatory Diseases
title_full_unstemmed	The Role of Glucocorticoids in Inflammatory Diseases
title_sort	role of glucocorticoids in inflammatory diseases
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/8259bbf6ae884f8d95dec4607745f541
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The Role of Glucocorticoids in Inflammatory Diseases

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