The influence of host and bacterial genotype on the development of disseminated disease with Mycobacterium tuberculosis.
The factors that govern the development of tuberculosis disease are incompletely understood. We hypothesized that some strains of Mycobacterium tuberculosis (M. tuberculosis) are more capable of causing disseminated disease than others and may be associated with polymorphisms in host genes responsib...
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Public Library of Science (PLoS)
2008
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/825b95682f4241aeb2902bf3cc19f3e6 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:825b95682f4241aeb2902bf3cc19f3e6 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:825b95682f4241aeb2902bf3cc19f3e62021-12-02T19:59:49ZThe influence of host and bacterial genotype on the development of disseminated disease with Mycobacterium tuberculosis.1553-73661553-737410.1371/journal.ppat.1000034https://doaj.org/article/825b95682f4241aeb2902bf3cc19f3e62008-03-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/18369480/pdf/?tool=EBIhttps://doaj.org/toc/1553-7366https://doaj.org/toc/1553-7374The factors that govern the development of tuberculosis disease are incompletely understood. We hypothesized that some strains of Mycobacterium tuberculosis (M. tuberculosis) are more capable of causing disseminated disease than others and may be associated with polymorphisms in host genes responsible for the innate immune response to infection. We compared the host and bacterial genotype in 187 Vietnamese adults with tuberculous meningitis (TBM) and 237 Vietnamese adults with uncomplicated pulmonary tuberculosis. The host genotype of tuberculosis cases was also compared with the genotype of 392 cord blood controls from the same population. Isolates of M. tuberculosis were genotyped by large sequence polymorphisms. The hosts were defined by polymorphisms in genes encoding Toll-interleukin 1 receptor domain containing adaptor protein (TIRAP) and Toll-like receptor-2 (TLR-2). We found a significant protective association between the Euro-American lineage of M. tuberculosis and pulmonary rather than meningeal tuberculosis (Odds ratio (OR) for causing TBM 0.395, 95% confidence intervals (C.I.) 0.193-0.806, P = 0.009), suggesting these strains are less capable of extra-pulmonary dissemination than others in the study population. We also found that individuals with the C allele of TLR-2 T597C allele were more likely to have tuberculosis caused by the East-Asian/Beijing genotype (OR = 1.57 [95% C.I. 1.15-2.15]) than other individuals. The study provides evidence that M. tuberculosis genotype influences clinical disease phenotype and demonstrates, for the first time, a significant interaction between host and bacterial genotypes and the development of tuberculosis.Maxine CawsGuy ThwaitesSarah DunstanThomas R HawnNguyen Thi Ngoc LanNguyen Thuy Thuong ThuongKasia StepniewskaMai Nguyet Thu HuyenNguyen Duc BangTran Huu LocSebastien GagneuxDick van SoolingenKristin KremerMarianne van der SandePeter SmallPhan Thi Hoang AnhNguyen Tran ChinhHoang Thi QuyNguyen Thi Hong DuyenDau Quang ThoNguyen T HieuEstee TorokTran Tinh HienNguyen Huy DungNguyen Thi Quynh NhuPhan Minh DuyNguyen van Vinh ChauJeremy FarrarPublic Library of Science (PLoS)articleImmunologic diseases. AllergyRC581-607Biology (General)QH301-705.5ENPLoS Pathogens, Vol 4, Iss 3, p e1000034 (2008) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5 |
| spellingShingle |
Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5 Maxine Caws Guy Thwaites Sarah Dunstan Thomas R Hawn Nguyen Thi Ngoc Lan Nguyen Thuy Thuong Thuong Kasia Stepniewska Mai Nguyet Thu Huyen Nguyen Duc Bang Tran Huu Loc Sebastien Gagneux Dick van Soolingen Kristin Kremer Marianne van der Sande Peter Small Phan Thi Hoang Anh Nguyen Tran Chinh Hoang Thi Quy Nguyen Thi Hong Duyen Dau Quang Tho Nguyen T Hieu Estee Torok Tran Tinh Hien Nguyen Huy Dung Nguyen Thi Quynh Nhu Phan Minh Duy Nguyen van Vinh Chau Jeremy Farrar The influence of host and bacterial genotype on the development of disseminated disease with Mycobacterium tuberculosis. |
| description |
The factors that govern the development of tuberculosis disease are incompletely understood. We hypothesized that some strains of Mycobacterium tuberculosis (M. tuberculosis) are more capable of causing disseminated disease than others and may be associated with polymorphisms in host genes responsible for the innate immune response to infection. We compared the host and bacterial genotype in 187 Vietnamese adults with tuberculous meningitis (TBM) and 237 Vietnamese adults with uncomplicated pulmonary tuberculosis. The host genotype of tuberculosis cases was also compared with the genotype of 392 cord blood controls from the same population. Isolates of M. tuberculosis were genotyped by large sequence polymorphisms. The hosts were defined by polymorphisms in genes encoding Toll-interleukin 1 receptor domain containing adaptor protein (TIRAP) and Toll-like receptor-2 (TLR-2). We found a significant protective association between the Euro-American lineage of M. tuberculosis and pulmonary rather than meningeal tuberculosis (Odds ratio (OR) for causing TBM 0.395, 95% confidence intervals (C.I.) 0.193-0.806, P = 0.009), suggesting these strains are less capable of extra-pulmonary dissemination than others in the study population. We also found that individuals with the C allele of TLR-2 T597C allele were more likely to have tuberculosis caused by the East-Asian/Beijing genotype (OR = 1.57 [95% C.I. 1.15-2.15]) than other individuals. The study provides evidence that M. tuberculosis genotype influences clinical disease phenotype and demonstrates, for the first time, a significant interaction between host and bacterial genotypes and the development of tuberculosis. |
| format |
article |
| author |
Maxine Caws Guy Thwaites Sarah Dunstan Thomas R Hawn Nguyen Thi Ngoc Lan Nguyen Thuy Thuong Thuong Kasia Stepniewska Mai Nguyet Thu Huyen Nguyen Duc Bang Tran Huu Loc Sebastien Gagneux Dick van Soolingen Kristin Kremer Marianne van der Sande Peter Small Phan Thi Hoang Anh Nguyen Tran Chinh Hoang Thi Quy Nguyen Thi Hong Duyen Dau Quang Tho Nguyen T Hieu Estee Torok Tran Tinh Hien Nguyen Huy Dung Nguyen Thi Quynh Nhu Phan Minh Duy Nguyen van Vinh Chau Jeremy Farrar |
| author_facet |
Maxine Caws Guy Thwaites Sarah Dunstan Thomas R Hawn Nguyen Thi Ngoc Lan Nguyen Thuy Thuong Thuong Kasia Stepniewska Mai Nguyet Thu Huyen Nguyen Duc Bang Tran Huu Loc Sebastien Gagneux Dick van Soolingen Kristin Kremer Marianne van der Sande Peter Small Phan Thi Hoang Anh Nguyen Tran Chinh Hoang Thi Quy Nguyen Thi Hong Duyen Dau Quang Tho Nguyen T Hieu Estee Torok Tran Tinh Hien Nguyen Huy Dung Nguyen Thi Quynh Nhu Phan Minh Duy Nguyen van Vinh Chau Jeremy Farrar |
| author_sort |
Maxine Caws |
| title |
The influence of host and bacterial genotype on the development of disseminated disease with Mycobacterium tuberculosis. |
| title_short |
The influence of host and bacterial genotype on the development of disseminated disease with Mycobacterium tuberculosis. |
| title_full |
The influence of host and bacterial genotype on the development of disseminated disease with Mycobacterium tuberculosis. |
| title_fullStr |
The influence of host and bacterial genotype on the development of disseminated disease with Mycobacterium tuberculosis. |
| title_full_unstemmed |
The influence of host and bacterial genotype on the development of disseminated disease with Mycobacterium tuberculosis. |
| title_sort |
influence of host and bacterial genotype on the development of disseminated disease with mycobacterium tuberculosis. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2008 |
| url |
https://doaj.org/article/825b95682f4241aeb2902bf3cc19f3e6 |
| work_keys_str_mv |
AT maxinecaws theinfluenceofhostandbacterialgenotypeonthedevelopmentofdisseminateddiseasewithmycobacteriumtuberculosis AT guythwaites theinfluenceofhostandbacterialgenotypeonthedevelopmentofdisseminateddiseasewithmycobacteriumtuberculosis AT sarahdunstan theinfluenceofhostandbacterialgenotypeonthedevelopmentofdisseminateddiseasewithmycobacteriumtuberculosis AT thomasrhawn theinfluenceofhostandbacterialgenotypeonthedevelopmentofdisseminateddiseasewithmycobacteriumtuberculosis AT nguyenthingoclan theinfluenceofhostandbacterialgenotypeonthedevelopmentofdisseminateddiseasewithmycobacteriumtuberculosis AT nguyenthuythuongthuong theinfluenceofhostandbacterialgenotypeonthedevelopmentofdisseminateddiseasewithmycobacteriumtuberculosis AT kasiastepniewska theinfluenceofhostandbacterialgenotypeonthedevelopmentofdisseminateddiseasewithmycobacteriumtuberculosis AT mainguyetthuhuyen theinfluenceofhostandbacterialgenotypeonthedevelopmentofdisseminateddiseasewithmycobacteriumtuberculosis AT nguyenducbang theinfluenceofhostandbacterialgenotypeonthedevelopmentofdisseminateddiseasewithmycobacteriumtuberculosis AT tranhuuloc theinfluenceofhostandbacterialgenotypeonthedevelopmentofdisseminateddiseasewithmycobacteriumtuberculosis AT sebastiengagneux theinfluenceofhostandbacterialgenotypeonthedevelopmentofdisseminateddiseasewithmycobacteriumtuberculosis AT dickvansoolingen theinfluenceofhostandbacterialgenotypeonthedevelopmentofdisseminateddiseasewithmycobacteriumtuberculosis AT kristinkremer theinfluenceofhostandbacterialgenotypeonthedevelopmentofdisseminateddiseasewithmycobacteriumtuberculosis AT mariannevandersande theinfluenceofhostandbacterialgenotypeonthedevelopmentofdisseminateddiseasewithmycobacteriumtuberculosis AT petersmall theinfluenceofhostandbacterialgenotypeonthedevelopmentofdisseminateddiseasewithmycobacteriumtuberculosis AT phanthihoanganh theinfluenceofhostandbacterialgenotypeonthedevelopmentofdisseminateddiseasewithmycobacteriumtuberculosis AT nguyentranchinh theinfluenceofhostandbacterialgenotypeonthedevelopmentofdisseminateddiseasewithmycobacteriumtuberculosis AT hoangthiquy theinfluenceofhostandbacterialgenotypeonthedevelopmentofdisseminateddiseasewithmycobacteriumtuberculosis AT nguyenthihongduyen theinfluenceofhostandbacterialgenotypeonthedevelopmentofdisseminateddiseasewithmycobacteriumtuberculosis AT dauquangtho theinfluenceofhostandbacterialgenotypeonthedevelopmentofdisseminateddiseasewithmycobacteriumtuberculosis AT nguyenthieu theinfluenceofhostandbacterialgenotypeonthedevelopmentofdisseminateddiseasewithmycobacteriumtuberculosis AT esteetorok theinfluenceofhostandbacterialgenotypeonthedevelopmentofdisseminateddiseasewithmycobacteriumtuberculosis AT trantinhhien theinfluenceofhostandbacterialgenotypeonthedevelopmentofdisseminateddiseasewithmycobacteriumtuberculosis AT nguyenhuydung theinfluenceofhostandbacterialgenotypeonthedevelopmentofdisseminateddiseasewithmycobacteriumtuberculosis AT nguyenthiquynhnhu theinfluenceofhostandbacterialgenotypeonthedevelopmentofdisseminateddiseasewithmycobacteriumtuberculosis AT phanminhduy theinfluenceofhostandbacterialgenotypeonthedevelopmentofdisseminateddiseasewithmycobacteriumtuberculosis AT nguyenvanvinhchau theinfluenceofhostandbacterialgenotypeonthedevelopmentofdisseminateddiseasewithmycobacteriumtuberculosis AT jeremyfarrar theinfluenceofhostandbacterialgenotypeonthedevelopmentofdisseminateddiseasewithmycobacteriumtuberculosis AT maxinecaws influenceofhostandbacterialgenotypeonthedevelopmentofdisseminateddiseasewithmycobacteriumtuberculosis AT guythwaites influenceofhostandbacterialgenotypeonthedevelopmentofdisseminateddiseasewithmycobacteriumtuberculosis AT sarahdunstan influenceofhostandbacterialgenotypeonthedevelopmentofdisseminateddiseasewithmycobacteriumtuberculosis AT thomasrhawn influenceofhostandbacterialgenotypeonthedevelopmentofdisseminateddiseasewithmycobacteriumtuberculosis AT nguyenthingoclan influenceofhostandbacterialgenotypeonthedevelopmentofdisseminateddiseasewithmycobacteriumtuberculosis AT nguyenthuythuongthuong influenceofhostandbacterialgenotypeonthedevelopmentofdisseminateddiseasewithmycobacteriumtuberculosis AT kasiastepniewska influenceofhostandbacterialgenotypeonthedevelopmentofdisseminateddiseasewithmycobacteriumtuberculosis AT mainguyetthuhuyen influenceofhostandbacterialgenotypeonthedevelopmentofdisseminateddiseasewithmycobacteriumtuberculosis AT nguyenducbang influenceofhostandbacterialgenotypeonthedevelopmentofdisseminateddiseasewithmycobacteriumtuberculosis AT tranhuuloc influenceofhostandbacterialgenotypeonthedevelopmentofdisseminateddiseasewithmycobacteriumtuberculosis AT sebastiengagneux influenceofhostandbacterialgenotypeonthedevelopmentofdisseminateddiseasewithmycobacteriumtuberculosis AT dickvansoolingen influenceofhostandbacterialgenotypeonthedevelopmentofdisseminateddiseasewithmycobacteriumtuberculosis AT kristinkremer influenceofhostandbacterialgenotypeonthedevelopmentofdisseminateddiseasewithmycobacteriumtuberculosis AT mariannevandersande influenceofhostandbacterialgenotypeonthedevelopmentofdisseminateddiseasewithmycobacteriumtuberculosis AT petersmall influenceofhostandbacterialgenotypeonthedevelopmentofdisseminateddiseasewithmycobacteriumtuberculosis AT phanthihoanganh influenceofhostandbacterialgenotypeonthedevelopmentofdisseminateddiseasewithmycobacteriumtuberculosis AT nguyentranchinh influenceofhostandbacterialgenotypeonthedevelopmentofdisseminateddiseasewithmycobacteriumtuberculosis AT hoangthiquy influenceofhostandbacterialgenotypeonthedevelopmentofdisseminateddiseasewithmycobacteriumtuberculosis AT nguyenthihongduyen influenceofhostandbacterialgenotypeonthedevelopmentofdisseminateddiseasewithmycobacteriumtuberculosis AT dauquangtho influenceofhostandbacterialgenotypeonthedevelopmentofdisseminateddiseasewithmycobacteriumtuberculosis AT nguyenthieu influenceofhostandbacterialgenotypeonthedevelopmentofdisseminateddiseasewithmycobacteriumtuberculosis AT esteetorok influenceofhostandbacterialgenotypeonthedevelopmentofdisseminateddiseasewithmycobacteriumtuberculosis AT trantinhhien influenceofhostandbacterialgenotypeonthedevelopmentofdisseminateddiseasewithmycobacteriumtuberculosis AT nguyenhuydung influenceofhostandbacterialgenotypeonthedevelopmentofdisseminateddiseasewithmycobacteriumtuberculosis AT nguyenthiquynhnhu influenceofhostandbacterialgenotypeonthedevelopmentofdisseminateddiseasewithmycobacteriumtuberculosis AT phanminhduy influenceofhostandbacterialgenotypeonthedevelopmentofdisseminateddiseasewithmycobacteriumtuberculosis AT nguyenvanvinhchau influenceofhostandbacterialgenotypeonthedevelopmentofdisseminateddiseasewithmycobacteriumtuberculosis AT jeremyfarrar influenceofhostandbacterialgenotypeonthedevelopmentofdisseminateddiseasewithmycobacteriumtuberculosis |
| _version_ |
1718375733310521344 |