Insight into the global evolution of Rodentia associated Morbilli-related paramyxoviruses

Abstract One portion of the family Paramyxoviridae is a group of Unclassified Morbilli-Related Viruses (UMRV) recently recognized in wild small mammals. At a global level, the evolutionary history of these viruses is not properly understood and the relationships between UMRV and their hosts still re...

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Autores principales:	Wissem Ghawar, Hervé Pascalis, Jihéne Bettaieb, Julien Mélade, Adel Gharbi, Mohamed Ali Snoussi, Dhafer Laouini, Steven M. Goodman, Afif Ben Salah, Koussay Dellagi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/825f490c3afc4b71baa549902f0a6db2
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spelling	oai:doaj.org-article:825f490c3afc4b71baa549902f0a6db22021-12-02T16:06:23ZInsight into the global evolution of Rodentia associated Morbilli-related paramyxoviruses10.1038/s41598-017-02206-02045-2322https://doaj.org/article/825f490c3afc4b71baa549902f0a6db22017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-02206-0https://doaj.org/toc/2045-2322Abstract One portion of the family Paramyxoviridae is a group of Unclassified Morbilli-Related Viruses (UMRV) recently recognized in wild small mammals. At a global level, the evolutionary history of these viruses is not properly understood and the relationships between UMRV and their hosts still remain largely unstudied. The present study revealed, for the first time, that Rodentia associated UMRV emerged from a common ancestor in southern Africa more than 4000 years ago. Sequenced UMRV originating from different regions in the world, clustered into four well-supported viral lineages, which suggest that strain diversification occurred during host dispersal and associated exchanges, with purifying selection pressure as the principal evolutionary force. In addition, multi-introductions on different continents and islands of Rodentia associated UMRV and spillover between rodent species, most probably Rattus rattus, were detected and indicate that these animals are implicated in the vectoring and in the worldwide emergence of this virus group. The natural history and the evolution dynamics of these zoonotic viruses, originating from and hosted by wild animals, are most likely shaped by commensalism related to human activities.Wissem GhawarHervé PascalisJihéne BettaiebJulien MéladeAdel GharbiMohamed Ali SnoussiDhafer LaouiniSteven M. GoodmanAfif Ben SalahKoussay DellagiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Wissem Ghawar Hervé Pascalis Jihéne Bettaieb Julien Mélade Adel Gharbi Mohamed Ali Snoussi Dhafer Laouini Steven M. Goodman Afif Ben Salah Koussay Dellagi Insight into the global evolution of Rodentia associated Morbilli-related paramyxoviruses
description	Abstract One portion of the family Paramyxoviridae is a group of Unclassified Morbilli-Related Viruses (UMRV) recently recognized in wild small mammals. At a global level, the evolutionary history of these viruses is not properly understood and the relationships between UMRV and their hosts still remain largely unstudied. The present study revealed, for the first time, that Rodentia associated UMRV emerged from a common ancestor in southern Africa more than 4000 years ago. Sequenced UMRV originating from different regions in the world, clustered into four well-supported viral lineages, which suggest that strain diversification occurred during host dispersal and associated exchanges, with purifying selection pressure as the principal evolutionary force. In addition, multi-introductions on different continents and islands of Rodentia associated UMRV and spillover between rodent species, most probably Rattus rattus, were detected and indicate that these animals are implicated in the vectoring and in the worldwide emergence of this virus group. The natural history and the evolution dynamics of these zoonotic viruses, originating from and hosted by wild animals, are most likely shaped by commensalism related to human activities.
format	article
author	Wissem Ghawar Hervé Pascalis Jihéne Bettaieb Julien Mélade Adel Gharbi Mohamed Ali Snoussi Dhafer Laouini Steven M. Goodman Afif Ben Salah Koussay Dellagi
author_facet	Wissem Ghawar Hervé Pascalis Jihéne Bettaieb Julien Mélade Adel Gharbi Mohamed Ali Snoussi Dhafer Laouini Steven M. Goodman Afif Ben Salah Koussay Dellagi
author_sort	Wissem Ghawar
title	Insight into the global evolution of Rodentia associated Morbilli-related paramyxoviruses
title_short	Insight into the global evolution of Rodentia associated Morbilli-related paramyxoviruses
title_full	Insight into the global evolution of Rodentia associated Morbilli-related paramyxoviruses
title_fullStr	Insight into the global evolution of Rodentia associated Morbilli-related paramyxoviruses
title_full_unstemmed	Insight into the global evolution of Rodentia associated Morbilli-related paramyxoviruses
title_sort	insight into the global evolution of rodentia associated morbilli-related paramyxoviruses
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/825f490c3afc4b71baa549902f0a6db2
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Insight into the global evolution of Rodentia associated Morbilli-related paramyxoviruses

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