Tyrosine dephosphorylated cortactin downregulates contractility at the epithelial zonula adherens through SRGAP1

Epithelial cell-cell adhesions are contractile junctions, but whether contractility can be down-regulated is not known. Here the authors report how tyrosine dephosphorylation of the cytoskeletal scaffold, cortactin, recruits the RhoA antagonist SRGAP1 to relax adherens junctions in response to HGF.

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Autores principales:	Xuan Liang, Srikanth Budnar, Shafali Gupta, Suzie Verma, Siew-Ping Han, Michelle M. Hill, Roger J. Daly, Robert G. Parton, Nicholas A. Hamilton, Guillermo A. Gomez, Alpha S. Yap
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/825f4db4af8b457a93e1d6628f784ef4
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spelling	oai:doaj.org-article:825f4db4af8b457a93e1d6628f784ef42021-12-02T14:40:24ZTyrosine dephosphorylated cortactin downregulates contractility at the epithelial zonula adherens through SRGAP110.1038/s41467-017-00797-w2041-1723https://doaj.org/article/825f4db4af8b457a93e1d6628f784ef42017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00797-whttps://doaj.org/toc/2041-1723Epithelial cell-cell adhesions are contractile junctions, but whether contractility can be down-regulated is not known. Here the authors report how tyrosine dephosphorylation of the cytoskeletal scaffold, cortactin, recruits the RhoA antagonist SRGAP1 to relax adherens junctions in response to HGF.Xuan LiangSrikanth BudnarShafali GuptaSuzie VermaSiew-Ping HanMichelle M. HillRoger J. DalyRobert G. PartonNicholas A. HamiltonGuillermo A. GomezAlpha S. YapNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xuan Liang Srikanth Budnar Shafali Gupta Suzie Verma Siew-Ping Han Michelle M. Hill Roger J. Daly Robert G. Parton Nicholas A. Hamilton Guillermo A. Gomez Alpha S. Yap Tyrosine dephosphorylated cortactin downregulates contractility at the epithelial zonula adherens through SRGAP1
description	Epithelial cell-cell adhesions are contractile junctions, but whether contractility can be down-regulated is not known. Here the authors report how tyrosine dephosphorylation of the cytoskeletal scaffold, cortactin, recruits the RhoA antagonist SRGAP1 to relax adherens junctions in response to HGF.
format	article
author	Xuan Liang Srikanth Budnar Shafali Gupta Suzie Verma Siew-Ping Han Michelle M. Hill Roger J. Daly Robert G. Parton Nicholas A. Hamilton Guillermo A. Gomez Alpha S. Yap
author_facet	Xuan Liang Srikanth Budnar Shafali Gupta Suzie Verma Siew-Ping Han Michelle M. Hill Roger J. Daly Robert G. Parton Nicholas A. Hamilton Guillermo A. Gomez Alpha S. Yap
author_sort	Xuan Liang
title	Tyrosine dephosphorylated cortactin downregulates contractility at the epithelial zonula adherens through SRGAP1
title_short	Tyrosine dephosphorylated cortactin downregulates contractility at the epithelial zonula adherens through SRGAP1
title_full	Tyrosine dephosphorylated cortactin downregulates contractility at the epithelial zonula adherens through SRGAP1
title_fullStr	Tyrosine dephosphorylated cortactin downregulates contractility at the epithelial zonula adherens through SRGAP1
title_full_unstemmed	Tyrosine dephosphorylated cortactin downregulates contractility at the epithelial zonula adherens through SRGAP1
title_sort	tyrosine dephosphorylated cortactin downregulates contractility at the epithelial zonula adherens through srgap1
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/825f4db4af8b457a93e1d6628f784ef4
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Tyrosine dephosphorylated cortactin downregulates contractility at the epithelial zonula adherens through SRGAP1

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